Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6HQDL)

Drug Name
CYANATE Drug Info
Synonyms
cyanate; ISOCYANATE; UNII-YML51WA0FW; YML51WA0FW; 661-20-1; 71000-82-3; UN2206; Cyanate ion(1-); Isocyanate ion(1-); Isocyanate ion (1-); Isocyanic acid, ion(1-); isocynate; Zyanat; Cyanat; carbonyl amide; hydrogen cyanate; UN3080; nitridooxidocarbonate(1-); AC1L2XX2; OCN(-); CHEBI:29195; CTK5I4582; CTK2H4173; BDBM26982; CNO(-1); IQPQWNKOIGAROB-UHFFFAOYSA-N; XLJMAIOERFSOGZ-UHFFFAOYSA-M; AC1Q2283; BDBM50098562; [C(N)O](-); Isocyanates, toxic, n.o.s. or isocyanate solutions, toxic, n.o.s., Fp 61 C and Bp 300 C; Isocyanates, toxic, n.o.s. o
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
105034
ChEBI ID
CHEMBL29195
CAS Number
CAS 71000-82-3
TTD Drug ID
DM6HQDL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [4]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [5]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [5]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [6]
Acetazolamide DM1AF5U Absence epilepsy Approved [5]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [7]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [8]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [9]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [7]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [11]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [14]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [22]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [23]
Etretinate DM2CZFA Keratosis ED56 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [29]
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Drug(s) Affected By Interleukin-12 subunit alpha (IL12A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [32]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [35]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [36]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Arsenic DMTL2Y1 N. A. N. A. Approved [39]
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Drug(s) Affected By Interleukin-12 subunit beta (IL12B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [32]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [41]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Capsaicin DMGMF6V Back pain ME84.Z Approved [43]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [44]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [45]
Bryostatin-1 DM1JOXY Alzheimer disease 8A20 Phase 2 [46]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [47]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Etretinate DM2CZFA Keratosis ED56 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [53]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [54]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
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Drug(s) Affected By Catenin alpha-3 (CTNNA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [57]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [58]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [59]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [60]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [61]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [62]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [63]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catenin alpha-3 (CTNNA3) OT9Z0P1E CTNA3_HUMAN Drug Response [2]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [3]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Gene/Protein Processing [3]
Interleukin-12 subunit beta (IL12B) OT0JF8A3 IL12B_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [3]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Post-Translational Modifications [3]

References

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3 Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes. J Biochem Mol Toxicol. 2008 Nov-Dec;22(6):429-40.
4 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
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13 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
14 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
15 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
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17 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
18 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
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21 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
22 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
23 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
24 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
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26 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
27 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
28 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
29 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
30 The influence of methotrexate on the gene expression of the pro-inflammatory cytokine IL-12A in the therapy of rheumatoid arthritis. Clin Exp Rheumatol. 2011 Nov-Dec;29(6):963-9. Epub 2011 Dec 22.
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36 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
37 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
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49 Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
50 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
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52 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
53 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
54 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
55 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
56 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
57 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
58 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
59 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
60 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
61 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
62 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
63 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.