Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8Y4JS)

Drug Name
Quizartinib Drug Info
Synonyms AC220
Indication
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Approved [1]
leukaemia 2A60-2B33 Phase 3 [2]
Cross-matching ID
PubChem CID
24889392
ChEBI ID
CHEMBL576982
CAS Number
CAS 950769-58-1
TTD Drug ID
DM8Y4JS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fms-like tyrosine kinase 3 (FLT-3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [7]
Intedanib DMSTA36 Colorectal cancer 2B91.Z Approved [8]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [9]
Gilteritinib DMTI0ZO Acute myeloid leukaemia 2A60 Approved [10]
Pexidartinib DMS2J0Z Tenosynovial giant cell tumour 2F7B Approved [11]
Pacritinib DM1T6ZN Myelofibrosis 2A20.2 Approved [6]
Lestaurtinib DMQ2AIJ Acute myeloid leukaemia 2A60 Approved (orphan drug) [12]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
BMS-690514 DMX302C Chronic pain MG30 Phase 2 [14]
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Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [20]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [21]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [22]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [29]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [34]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [35]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [38]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [39]
Panobinostat DM58WKG Chronic graft versus host disease Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [42]
Testosterone DM7HUNW Hot flushes GA30 Approved [43]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [50]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [51]
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Gefitinib DM15F0X Colon adenocarcinoma Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [57]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [59]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
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Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Etretinate DM2CZFA Keratosis ED56 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [30]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [34]
Testosterone DM7HUNW Hot flushes GA30 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Leflunomide DMR8ONJ Arthritis FA20 Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [66]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [67]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Selenium DM25CGV N. A. N. A. Approved [70]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [71]
Etretinate DM2CZFA Keratosis ED56 Approved [62]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [73]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [74]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [77]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [81]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [82]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [83]
Gefitinib DM15F0X Colon adenocarcinoma Approved [84]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [87]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [78]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [88]
Paclitaxel DMLB81S Breast carcinoma Approved [89]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [77]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [92]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [80]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [81]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [95]
Gefitinib DM15F0X Colon adenocarcinoma Approved [96]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Etretinate DM2CZFA Keratosis ED56 Approved [98]
Prednisone DM2HG4X Acute asthma CA23 Approved [99]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [58]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [100]
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Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [104]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [106]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [107]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [108]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [109]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [110]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fms-like tyrosine kinase 3 (FLT-3) TTGJCWZ FLT3_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [5]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [4]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Post-Translational Modifications [5]
Replication protein A 32 kDa subunit (RPA2) OTZ54WAF RFA2_HUMAN Post-Translational Modifications [5]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Gene/Protein Processing [5]

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 216993
2 ClinicalTrials.gov (NCT02039726) An Open-label Study of Quizartinib Monotherapy vs. Salvage Chemotherapy in Acute Myeloid Leukemia (AML) Subjects. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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5 Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
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30 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
31 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
32 Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
33 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
34 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
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37 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
38 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
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48 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
49 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
50 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
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52 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
53 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
54 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
55 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
56 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
57 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
58 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
59 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
60 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
61 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
62 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
63 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
64 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
65 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
66 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
67 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
68 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
69 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
70 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
71 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
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