Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBY56U)

• Drug Name: EXISULIND Drug Info
• Synonyms: Aposulind; Aptosyn; Sulindac sulfone; FGN-1; Prevatac (former Brand Name); Exisulind; (Z)-5-Fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-indene-3-acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 5472495
  ChEBI ID: CHEBI:64212
  CAS Number: CAS 59973-80-7
  TTD Drug ID: DMBY56U

Molecule-Related Drug Atlas

Drug(s) Targeting Phosphodiesterase 5A (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[10]
Udenafil	DM1IQRP	Erectile dysfunction	HA01.1	Approved	[11]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[12]
Dipyridamole	DMXY30O	Atrial fibrillation	BC81.3	Approved	[13]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[14]
Avanafil	DM75CXN	Erectile dysfunction	HA01.1	Approved	[15]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[16]
ICARIIN	DMOJQGT	N. A.	N. A.	Phase 3	[17]
PF-489791	DM3C8GQ	Chronic obstructive pulmonary disease	CA22	Phase 2	[18]
UK-371800	DMI8795	Erectile dysfunction	HA01.1	Phase 1	[19]

Drug(s) Affected By cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[27]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[28]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[29]

Drug(s) Affected By cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[34]
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[48]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[51]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[52]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[53]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[58]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[64]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[65]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[62]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[66]

Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[70]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[29]
Methamphetamine	DMPM4SK	Anxiety		Approved	[71]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[73]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[77]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[29]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[78]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[79]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[80]

Drug(s) Affected By Transcription factor GATA-6 (GATA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[81]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Indomethacin	DMSC4A7	Bursitis		Approved	[85]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[86]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[87]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[88]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[90]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[91]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[92]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[99]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[103]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[102]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[124]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[129]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[133]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[137]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[140]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[141]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[144]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[145]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[147]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]

Drug(s) Affected By Adenosine 5'-monophosphoramidase HINT1 (HINT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[155]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[157]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[161]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[166]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[145]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[169]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[148]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[174]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[175]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[176]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[148]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[179]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[183]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[186]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[187]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[194]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[196]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[197]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[198]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[204]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[205]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[117]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[212]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[219]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[220]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[4]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[223]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[224]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[225]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[226]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[228]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[145]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[231]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[232]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[233]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[235]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[236]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[237]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[238]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[239]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[242]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[233]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[243]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[244]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[232]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[235]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[236]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[246]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[247]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[247]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[251]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[254]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[255]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[94]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[94]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[256]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[249]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[258]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[260]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[263]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein epsilon	OT3WQXNA	1433E_HUMAN	Gene/Protein Processing	[3]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[4]
Adenosine 5'-monophosphoramidase HINT1 (HINT1)	OTQIR8LF	HINT1_HUMAN	Gene/Protein Processing	[5]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[6]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[7]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[8]
cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A)	OTZESF4H	PDE2A_HUMAN	Gene/Protein Processing	[8]
cGMP-dependent protein kinase 1 (PRKG1)	OTPAS4LF	KGP1_HUMAN	Gene/Protein Processing	[9]
cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)	OTT8Q1AP	PDE5A_HUMAN	Gene/Protein Processing	[8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[5]

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