Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDKLB5)

Drug Name
Puromycin Drug Info
Synonyms
puromycin; Stylomycin; Puromycinum; Puromycine; Puromicina; UNII-4A6ZS6Q2CL; P-638; Stillomycin; CL 13900; 3123L; 4A6ZS6Q2CL; 3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine; (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine; GNF-PF-2016; Puromycinum [INN-Latin]; Puromycine [INN-French]; Puromicina [INN-Spanish]; 9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-beta-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amine; Bacterenomycin
Cross-matching ID
PubChem CID
439530
ChEBI ID
CHEMBL469912
CAS Number
CAS 53-79-2
TTD Drug ID
DMDKLB5
VARIDT Drug ID
DR01525

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [8]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Methotrexate DM2TEOL Anterior urethra cancer Approved [10]
Folic Acid DMEMBJC Colorectal carcinoma Approved [11]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [10]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [10]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [12]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [10]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [13]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [14]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Folic Acid DMEMBJC Colorectal carcinoma Approved [17]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [19]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [20]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [21]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [22]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [23]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [24]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [25]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [26]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [27]
Cepharanthine DM9Y5JB N. A. N. A. Approved [28]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [29]
Clozapine DMFC71L Schizophrenia 6A20 Approved [30]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [31]
Trifluoperazine DMKBYWI Anxiety Approved [32]
Olanzapine DMPFN6Y Bipolar depression Approved [30]
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Drug(s) Affected By Nephrin (NPHS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [36]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [37]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [38]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [39]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [40]
PIRINIXIC ACID DM82Y75 Pulmonary fibrosis CB03.4 Preclinical [37]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [41]
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Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Testosterone enanthate DMB6871 N. A. N. A. Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [5]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [49]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [50]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [51]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [57]
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Drug(s) Affected By C-C motif chemokine 4 (CCL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [62]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [64]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [35]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [5]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [66]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [71]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [72]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [79]
Selenium DM25CGV N. A. N. A. Approved [80]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [83]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [84]
Quercetin DM3NC4M Obesity 5B81 Approved [85]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [60]
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Drug(s) Affected By Differentially expressed in FDCP 6 homolog (DEF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [87]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [88]
Bortezomib DMNO38U Leukemia Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [92]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [93]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [93]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [94]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [1]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [3]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [4]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Gene/Protein Processing [5]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Protein Interaction/Cellular Processes [6]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]
Nephrin (NPHS1) OT21JD3P NPHN_HUMAN Protein Interaction/Cellular Processes [7]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Gene/Protein Processing [5]

References

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70 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
71 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
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73 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
74 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
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78 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
79 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
80 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
81 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
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