Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMF1CM7)

• Drug Name: Icosapentum Drug Info
• Synonyms: Eicosapentaenoic acid; Icosapent; Icosapent [INN]; Icosapentaenoic acid; Icosapento; Cis-5,8,11,14,17-eicosapentaenoic acid; Timnodonic acid; (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid; (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid; (all-Z)-5,8,11,14,17-Eicosapentaenoic acid; 10417-94-4; 5,8,11,14,17-EICOSAPENTAENOIC ACID; 5,8,11,14,17-Icosapentaenoic acid; 5Z,8Z,11Z,14Z,17Z-Eicosapentaenoic acid; AAN7QOV9EA; C20:5 omega-3; CCRIS 3279; CHEBI:28364; CHEMBL460026; EPA; UNII-AAN7QOV9EA; cis-5,8,11,14,17-Eicosapentaenoic acid
• Cross-matching ID:
  PubChem CID: 446284
  ChEBI ID: CHEBI:28364
  CAS Number: CAS 10417-94-4
  TTD Drug ID: DMF1CM7
  INTEDE Drug ID: DR1991

Molecule-Related Drug Atlas

Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[8]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[8]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[8]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[8]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[8]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[8]
Ketobemidone	DMM3L6Z	Pain	MG30-MG3Z	Approved	[8]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[8]

Drug(s) Metabolized By Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[8]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[1]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[10]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[1]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[1]
Omega-6-FA	DMBWY8V	N. A.	N. A.	Phase 3	[11]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[12]
alpha-linolenic acid	DMY64HE	Discovery agent	N.A.	Investigative	[1]
Eicosadienoic acid	DMVJK9W	N. A.	N. A.	Investigative	[1]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[13]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[14]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[7]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[16]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[17]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Haloperidol	DM96SE0	Delirium		Approved	[23]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[24]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[27]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[45]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[48]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[49]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[48]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[64]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[64]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[64]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[65]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[66]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[67]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[68]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[69]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[70]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[23]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[71]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[72]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[23]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[77]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[78]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[80]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[81]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[83]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[84]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[85]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[86]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[82]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[81]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[65]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[88]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[82]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[6]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[81]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[82]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[77]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[81]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[89]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[65]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[82]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[67]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[82]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[77]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[23]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[92]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[93]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[96]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[97]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[100]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[101]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[109]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[110]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[110]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[111]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[115]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[117]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[118]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[123]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[125]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[126]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[127]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[129]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[133]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[136]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[143]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[144]
Fructose	DM43AN2	Vomiting	MD90	Approved	[23]
Ketoprofen	DMRKXPT	Bursitis		Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[147]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[148]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[152]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[20]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[154]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[155]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[156]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Haloperidol	DM96SE0	Delirium		Approved	[162]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[23]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[166]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[172]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[177]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[178]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[135]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[179]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[116]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[116]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[180]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[23]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[181]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[182]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[172]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[172]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[172]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]

Drug(s) Affected By Resistin (RETN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[178]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[196]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[197]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[198]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[199]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[201]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[202]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Fructose	DM43AN2	Vomiting	MD90	Approved	[204]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[205]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[208]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[209]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[210]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[209]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[23]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[212]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[214]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[215]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[216]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	DE492CE	PGH2_HUMAN	Substrate	[1]
Prostaglandin G/H synthase 1 (COX-1)	DE073H6	PGH1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Protein Interaction/Cellular Processes	[2]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[3]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Gene/Protein Processing	[4]
Cytochrome b-245 light chain (CYBA)	OT16N9ZO	CY24A_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 2E1 (CYP2E1)	OTHQ17JG	CP2E1_HUMAN	Gene/Protein Processing	[6]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Gene/Protein Processing	[6]
Glutamate--cysteine ligase catalytic subunit (GCLC)	OTESDI4D	GSH1_HUMAN	Gene/Protein Processing	[7]

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