General Information of Drug (ID: DMG8KS9)

Drug Name
Phenanthrene-9,10-dione Drug Info
Synonyms
Phenanthrene-9,10-dione; 9,10-Phenanthrenequinone; 84-11-7; Phenanthrenequinone; 9,10-PHENANTHRENEDIONE; 9,10-Phenanthraquinone; Phenanthraquinone; 9,10-Phenanthroquinone; 9-10 Phenanthrene quinone; UNII-42L7BZ8H74; CCRIS 7615; Phenanthrene, 9,10-dihydro-9,10-dioxo-; HSDB 4489; EINECS 201-515-5; NSC 10446; phenanthrene-9,10-quinone; BRN 0608838; SMR000150826; CHEMBL51931; MLS000881132; MLS000571180; AI3-23739; CHEBI:37454; YYVYAPXYZVYDHN-UHFFFAOYSA-N; 42L7BZ8H74; MFCD00001163; 9,10-dihydrophenanthrene-9,10-dione; AK-96664
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6763
ChEBI ID
CHEMBL37454
CAS Number
CAS 84-11-7
TTD Drug ID
DMG8KS9
INTEDE Drug ID
DR0026

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [10]
PACTIMIBE DM0NZDT Arteriosclerosis BD40 Phase 2/3 [11]
K-604 DMQVN6P Arteriosclerosis BD40 Phase 2 [12]
Eldacimibe DML7WP0 Hyperlipidaemia 5C80 Phase 2 [13]
GR148672X DM7W6YN Acute lymphoblastic leukaemia 2A85 Clinical trial [14]
Avasimibe DMFG4OM Peripheral vascular disease BD4Z Discontinued in Phase 3 [15]
E-5324 DM562BM Hyperlipidaemia 5C80 Discontinued in Phase 2 [16]
RP-64477 DMTQ3BS Hyperlipidaemia 5C80 Discontinued in Phase 2 [17]
CI-976 DMBO28J Hyperlipidaemia 5C80 Discontinued in Phase 2 [18]
CL-283796 DM7LIDT Hyperlipidaemia 5C80 Discontinued in Phase 2 [19]
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Drug(s) Targeting Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hexafluronium bromide DMFY307 Spasm MB47.3 Approved [20]
MEPTAZINOL DMPSB8F Pain MG30-MG3Z Approved [21]
Eptastigmine DMTV7ZM Cognitive impairment 6D71 Phase 3 [22]
(-)-Phenserine DMNCY1I Alzheimer disease 8A20 Phase 3 [23]
Plasma derived human butyrylcholinesterase DMF3IBC Neurotoxicity NE61 Phase 1 [24]
Protexia DME1Y9W Alzheimer disease 8A20 Phase 1 [25]
JES-9501 DMYR3IE Alzheimer disease 8A20 Phase 1 [26]
Tetra-hydro-isoquinoline derivative 3 DMCZA45 N. A. N. A. Patented [27]
Tetra-hydro-isoquinoline derivative 1 DML86IO N. A. N. A. Patented [27]
Tetra-hydro-isoquinoline derivative 2 DM5CKVF N. A. N. A. Patented [27]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [28]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [29]
FENOFIBRIC ACID DMGO2MC Cardiovascular disease BA00-BE2Z Approved [30]
PGF2alpha DM4XAU7 Solid tumour/cancer 2A00-2F9Z Clinical trial [31]
VUFB-11502 DM7WFR0 N. A. N. A. Preclinical [32]
BRN-3548355 DM4KXT0 N. A. N. A. Investigative [33]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [34]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [35]
Trastuzumab emtansine DMU1LXS HER2-positive breast cancer 2C60-2C65 Phase 2 [36]
1H-Indole-2,3-dione DMOZ91H Discovery agent N.A. Investigative [37]
Nitrobenzaldehyde DM4UHB5 N. A. N. A. Investigative [34]
ACMC-209cv7 DMQCSFB N. A. N. A. Investigative [34]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [41]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [42]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [43]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [44]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [47]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [49]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [51]
Desogestrel DM27U4Y Contraception QA21 Approved [51]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [38]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [59]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [60]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [60]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [68]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [69]
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Drug(s) Affected By Claudin-5 (CLDN5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [71]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [72]
Glycine DMIOZ29 Allergic rhinitis CA08.0 Approved [73]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [74]
Urethane DM7NSI0 N. A. N. A. Phase 4 [75]
CS-600G DM1PV4Y N. A. N. A. Phase 3 [76]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [77]
LY294002 DMY1AFS Neuroblastoma 2D11.2 Phase 1 [78]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [73]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [79]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [81]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [82]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [83]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [87]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [85]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [90]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [91]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [94]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [98]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [89]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [99]
Paclitaxel DMLB81S Breast carcinoma Approved [100]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [101]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [88]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [102]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [91]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [104]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [107]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [109]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [110]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [111]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [112]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [49]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [115]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [49]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [117]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [119]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [49]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [120]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [121]
Ethacrynic acid DM60QMR Edema MG29 Approved [120]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [123]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [125]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [47]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [9]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [9]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [129]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [127]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [130]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [107]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [133]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [134]
Diazepam DM08E9O Alcohol withdrawal Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Benzbromarone DMC3YUA Gout FA25 Approved [135]
Flufenamic Acid DMC8VNH Dysmenorrhea GA34.3 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [126]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [50]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [50]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [136]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [137]
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Drug(s) Affected By L-xylulose reductase (DCXR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [139]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [106]
Ethanol DMDRQZU Chronic pain MG30 Approved [140]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [41]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [130]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [141]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [1]
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
NADPH-dependent carbonyl reductase 1 (CBR1) DE9JFMC CBR1_HUMAN Substrate [2]
Small intestine reductase (AKR1B10) DEP6GT1 AK1BA_HUMAN Substrate [3]
NADPH-dependent carbonyl reductase 3 (CBR3) DEIVKZ8 CBR3_HUMAN Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) OTGEDDM2 ARK72_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Biotransformations [4]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [3]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Regulation of Drug Effects [5]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Regulation of Drug Effects [5]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [6]
Aldo-keto reductase family 1 member C4 (AKR1C4) OTW2MMOF AK1C4_HUMAN Biotransformations [7]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [6]
Claudin-5 (CLDN5) OTUX60YO CLD5_HUMAN Gene/Protein Processing [8]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Biotransformations [9]

References

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2 Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3. Chem Biol Interact. 2011 May 30;191(1-3):95-103.
3 Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10. Toxicol Appl Pharmacol. 2014 Jul 15;278(2):180-9.
4 Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):487-504.
5 An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies. Biochem Pharmacol. 2008 Jan 15;75(2):484-93.
6 Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1. Chem Biol Interact. 2018 Jan 5;279:10-20.
7 Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily. Biochem J. 2011 Dec 15;440(3):335-44.
8 9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicology. 2021 Sep;461:152896. doi: 10.1016/j.tox.2021.152896. Epub 2021 Aug 12.
9 Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chem Biol Interact. 2019 May 25;305:12-20. doi: 10.1016/j.cbi.2019.03.026. Epub 2019 Mar 26.
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19 ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys. J Lipid Res. 1995 Jun;36(6):1199-210.
20 Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats. Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90.
21 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36.
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23 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.
24 Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8.
25 In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005 Dec 15;157-158:363-5.
26 Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
27 A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.
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31 Metabolism of prostaglandins by the nonpregnant human uterus. J Clin Endocrinol Metab. 1983 Apr;56(4):678-85.
32 The critical role of oxidative stress in the toxicity and metabolism of quinoxaline 1,4-di-N-oxides in vitro and in vivo. Drug Metab Rev. 2016 May;48(2):159-82.
33 Characterization of enzymes participating in carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human placenta. Chem Biol Interact. 2001 Jan 30;130-132(1-3):737-48.
34 Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol Cell Biochem. 2008 Aug;315(1-2):113-21.
35 Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. J Pharmacol Exp Ther. 2010 Mar;332(3):755-63.
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