Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGCF51)

Drug Name
Wogonin Drug Info
Synonyms
Wogonin; 632-85-9; 5,7-Dihydroxy-8-methoxyflavone; Vogonin; Norwogonin 8-methyl ether; UNII-POK93PO28W; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-methoxy-2-phenyl-; BRN 0287152; POK93PO28W; 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one; CHEMBL16171; FLAVONE, 5,7-DIHYDROXY-8-METHOXY-; CHEBI:10043; XLTFNNCXVBYBSX-UHFFFAOYSA-N; 5,7-dihydroxy-8-methoxy-2-phenylchromen-4-one; 5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one; ST077088; Q-100730; 5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5281703
ChEBI ID
CHEMBL16171
CAS Number
CAS 632-85-9
TTD Drug ID
DMGCF51

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Xanthine dehydrogenase/oxidase (XDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Allopurinol DMLPAOB Gout FA25 Approved [7]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [8]
Fosdenopterin DMR0TYK Molybdenum cofactor deficiency 5B5K.A Approved [9]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
Oxypurinol DMURH4X Heart failure BD10-BD13 Phase 2/3 [11]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [2]
Topiroxostat DMA04DE Gout FA25 Phase 2 [12]
TMX-049 DME8PFQ Diabetic nephropathy GB61.Z Phase 2 [13]
LC-350189 DMHT3CB Gout FA25 Phase 1 [14]
Azaindole derivative 5 DMD2BL3 N. A. N. A. Patented [15]
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Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [16]
Naproxen DMZ5RGV Bursitis Approved [17]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [18]
Indomethacin DMSC4A7 Bursitis Approved [19]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [20]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [21]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [22]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [23]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [24]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [19]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [25]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [28]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [29]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [30]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [33]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [31]
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Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [34]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [36]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [37]
Testosterone DM7HUNW Hot flushes GA30 Approved [38]
Haloperidol DM96SE0 Delirium Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [41]
Ethanol DMDRQZU Chronic pain MG30 Approved [42]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [45]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [46]
Etretinate DM2CZFA Keratosis ED56 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [50]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [56]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [58]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [63]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [54]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [64]
Paclitaxel DMLB81S Breast carcinoma Approved [65]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [66]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [56]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [74]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [76]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [77]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [78]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [81]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Etretinate DM2CZFA Keratosis ED56 Approved [84]
Prednisone DM2HG4X Acute asthma CA23 Approved [85]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [86]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [87]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Prednisone DM2HG4X Acute asthma CA23 Approved [85]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [93]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [95]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Gefitinib DM15F0X Colon adenocarcinoma Approved [98]
Prednisone DM2HG4X Acute asthma CA23 Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [100]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Fluoxetine DM3PD2C Bipolar depression Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [106]
Selenium DM25CGV N. A. N. A. Approved [45]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [107]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [108]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [110]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [113]
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Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [115]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [115]
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [115]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [115]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [116]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [115]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [117]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [115]
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Drug(s) Affected By Organic anion transporter 3 (SLC22A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [119]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [120]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [121]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [121]
Cefdinir DMJ7A0H Bacterial infection 1A00-1C4Z Approved [122]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [122]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [123]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [124]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [1]
Xanthine dehydrogenase/oxidase (XDH) TT7RJY8 XDH_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [4]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Gene/Protein Processing [3]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Gene/Protein Processing [4]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Gene/Protein Processing [3]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Gene/Protein Processing [6]

References

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28 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
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49 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
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51 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
52 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
53 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
54 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
55 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
56 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
57 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
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