Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGOURX)

Drug Name
USNIC ACID Drug Info
Synonyms
usnic acid; 125-46-2; Usniacin; Usno; Usninsaeure [German]; (+-)-Uanic acid; usnic-acid; Usinic acid; L-Usnic acid; NSC 8517; CCRIS 5518; HSDB 7170; NSC5890; 1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl-; C18H16O7; EINECS 204-740-7; BRN 1299865; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bH)-dibenzofurandione; AI3-50457; CHEBI:2264; NSC8517; NSC5889; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bh)-dione
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5646
ChEBI ID
CHEMBL2264
CAS Number
CAS 125-46-2
TTD Drug ID
DMGOURX

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting PTPN1 messenger RNA (PTPN1 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [8]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [9]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [10]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [11]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [12]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [13]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [13]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [13]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [13]
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Drug(s) Affected By C-C motif chemokine 21 (CCL21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [17]
Arsenic DMTL2Y1 N. A. N. A. Approved [18]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [22]
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Drug(s) Affected By Cyclin-C (CCNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [23]
Testosterone DM7HUNW Hot flushes GA30 Approved [24]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [26]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [17]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [27]
Arsenic DMTL2Y1 N. A. N. A. Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [29]
Inecalcitol oral DMU5SZP Acute myeloid leukaemia 2A60 Phase 2 [30]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [35]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [40]
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Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [43]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [46]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [47]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [48]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [49]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [51]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [52]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [53]
Testosterone DM7HUNW Hot flushes GA30 Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Capsaicin DMGMF6V Back pain ME84.Z Approved [55]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Gefitinib DM15F0X Colon adenocarcinoma Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [60]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [61]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [60]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [62]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [63]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [68]
Etretinate DM2CZFA Keratosis ED56 Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [71]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [75]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Selenium DM25CGV N. A. N. A. Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [78]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [79]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [80]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [81]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [88]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [89]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [90]
Gefitinib DM15F0X Colon adenocarcinoma Approved [91]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [92]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [94]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [85]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [95]
Paclitaxel DMLB81S Breast carcinoma Approved [96]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [97]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [84]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [98]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [87]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [88]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [101]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [75]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [76]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [103]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [104]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Etretinate DM2CZFA Keratosis ED56 Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [112]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [113]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [114]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
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Drug(s) Affected By Stromal interaction molecule 1 (STIM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [117]
Ethanol DMDRQZU Chronic pain MG30 Approved [118]
Benzatropine DMF7EXL Parkinsonian disorder Approved [119]
Clozapine DMFC71L Schizophrenia 6A20 Approved [119]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [121]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [22]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [122]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [123]
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Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [124]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [106]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [124]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [117]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [127]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
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Drug(s) Affected By Calcium release-activated calcium channel protein 1 (ORAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Testosterone DM7HUNW Hot flushes GA30 Approved [24]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [16]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [126]
Ethanol DMDRQZU Chronic pain MG30 Approved [118]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [131]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [132]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [22]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C motif chemokine 21 (CCL21) OT7DOXEM CCL21_HUMAN Gene/Protein Processing [2]
Calcium release-activated calcium channel protein 1 (ORAI1) OT2VE9UU CRCM1_HUMAN Gene/Protein Processing [3]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Gene/Protein Processing [3]
Cyclin-C (CCNC) OTMVK4K4 CCNC_HUMAN Gene/Protein Processing [2]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Gene/Protein Processing [3]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Gene/Protein Processing [4]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [5]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [6]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [6]

References

1 Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum. J Nat Prod. 2008 Apr;71(4):710-2.
2 Effects of usnic acid exposure on human hepatoblastoma HepG2 cells in culture. J Appl Toxicol. 2012 Sep;32(9):722-30.
3 Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells. Toxicol Sci. 2015 Jul;146(1):116-26. doi: 10.1093/toxsci/kfv075. Epub 2015 Apr 13.
4 Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. Arch Toxicol. 2017 Mar;91(3):1293-1307.
5 Usnic acid induces apoptosis in human gastric cancer cells through ROS generation and DNA damage and causes up-regulation of DNA-PKcs and -H2A.X phosphorylation. Chem Biol Interact. 2020 Jan 5;315:108898. doi: 10.1016/j.cbi.2019.108898. Epub 2019 Nov 9.
6 The role of autophagy in usnic acid-induced toxicity in hepatic cells. Toxicol Sci. 2014 Nov;142(1):33-44. doi: 10.1093/toxsci/kfu154. Epub 2014 Jul 30.
7 Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
8 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
9 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
10 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
11 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
12 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
13 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
14 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
15 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
16 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
17 The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis. Redox Biol. 2020 Sep;36:101594. doi: 10.1016/j.redox.2020.101594. Epub 2020 May 29.
18 Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
19 Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.
20 Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil Steril. 2009 Aug;92(2):709-21.
21 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
22 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
23 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
24 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
25 The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor. J Mol Biol. 2005 Jun 3;349(2):248-60. doi: 10.1016/j.jmb.2005.03.060. Epub 2005 Apr 7.
26 Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
27 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
28 Arsenic-induced cell proliferation is associated with enhanced ROS generation, Erk signaling and CyclinA expression. Toxicol Lett. 2010 Oct 5;198(2):263-71. doi: 10.1016/j.toxlet.2010.07.006. Epub 2010 Jul 21.
29 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
30 Two novel 14-Epi-analogues of 1,25-dihydroxyvitamin D3 inhibit the growth of human breast cancer cells in vitro and in vivo. Cancer Res. 2000 May 15;60(10):2673-9.
31 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
32 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
33 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
34 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
35 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
36 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
37 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
38 Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
39 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
40 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
41 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
42 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
43 Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
44 Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
45 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
46 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
47 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
48 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
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