Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIZ6W2)

Drug Name
Norfloxacin Drug Info
Synonyms
Baccidal; Barazan; Chibroxin; Fulgram; Lexinor; NFLX; Norflo; Norfloxacine; Norfloxacino; Norfloxacinum; Noroxin; Sebercim; Merck Brand of Norfloxacin; Norfloxacin Merck Brand; AM 0715; AM 715; AM0715; MK 0366; MK 366; MK0366; MK366; AM-0715; AM-715; Chibroxin (TN); Insensye (TN); MK-0366; MK-366; Norflohexal (TN); Norfloxacine [INN-French]; Norfloxacino [INN-Spanish]; Norfloxacinum [INN-Latin]; Norfocin (TN); Noroxin (TN); Nufloxib (TN); Roxin (TN); Utin (TN); Utinor (TN); Apo-Norflox (TN); Norfloxacin (JP15/USP/INN); Norfloxacin [USAN:BAN:INN:JAN]; Chibroxin, MK-366, Baccidal, Sebercim, Zoroxin, Norfloxacin; 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluor-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-chinolincarbonsaeure; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[1-piperazinyl]-3-quinoline-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid; 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis Approved [1]
Acute maxillary sinusitis Approved [1]
Anthrax 1B97 Approved [1]
Bacillary dysentery 1A02 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Bronchitis CA20 Approved [1]
Chancroid Approved [1]
Chronic tubotympanic suppurative otitis media Approved [1]
Cystitis GC00 Approved [1]
Endomyometritis Approved [1]
Malignant otitis externa caused by Pseudomonas aeruginosa Approved [1]
Mycoplasma pneumoniae pneumonia Approved [1]
Peritonitis Approved [1]
Pneumonia CA40 Approved [1]
Prostatitis Approved [1]
Pyelonephritis Approved [1]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Streptococcal pneumonia Approved [1]
Traveler's diarrhea ME05.1 Approved [1]
Urinary tract infection GC08 Approved [1]
Pneumonia caused by chlamydia Investigative [1]
Pneumonia due to Klebsiella pneumoniae CA40.03 Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
4539
ChEBI ID
CHEBI:100246
CAS Number
CAS 70458-96-7
TTD Drug ID
DMIZ6W2
VARIDT Drug ID
DR01204
INTEDE Drug ID
DR1176
ACDINA Drug ID
D00479

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial DNA gyrase (Bact gyrase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Grepafloxacin DMGLX0T Chronic bronchitis CA20.1 Approved [12]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [3]
Levofloxacin DMS60RB Acute maxillary sinusitis Approved [3]
Gatifloxacin DMSL679 Acute gonococcal cervicitis Approved [3]
Ozenoxacin DM6KZMG Impetigo 1B72 Approved [13]
Sparfloxacin DMB4HCT Bacterial infection 1A00-1C4Z Approved [3]
Gemifloxacin DMHT34O Bacterial infection 1A00-1C4Z Approved [3]
Besifloxacin DMPHXMI Ocular inflammation 9C61.24 Approved [14]
Finafloxacin DMZEONG Urinary tract infection GC08 Approved [15]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [3]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [6]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Folic Acid DMEMBJC Colorectal carcinoma Approved [18]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [19]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [21]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [35]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [36]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [37]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [38]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [39]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [40]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [41]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [42]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [47]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [48]
Verapamil DMA7PEW Angina pectoris BA40 Approved [49]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [50]
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Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [58]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [61]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [64]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [65]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [70]
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Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [73]
Quercetin DM3NC4M Obesity 5B81 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [76]
Leflunomide DMR8ONJ Arthritis FA20 Approved [77]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [78]
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Drug(s) Affected By Collagenase 3 (MMP13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [9]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [79]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [80]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [81]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [79]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [84]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [85]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [61]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [66]
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [88]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Meloxicam DM2AR7L Arthritis FA20 Approved [91]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [92]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [93]
Quinidine DMLPICK N. A. N. A. Approved [94]
Verapamil DMA7PEW Angina pectoris BA40 Approved [95]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [96]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [96]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [97]
Propranolol DM79NTF Angina pectoris BA40 Approved [98]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [99]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [100]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [96]
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Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [101]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [103]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [53]
Selenium DM25CGV N. A. N. A. Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [109]
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Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [110]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [86]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [104]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [111]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [116]
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Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [10]
Quercetin DM3NC4M Obesity 5B81 Approved [117]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [118]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [10]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [119]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [10]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [10]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [10]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial DNA gyrase (Bact gyrase) TTN6J5F GYRA_STAAU; GYRB_STAAU Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [4]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [8]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [8]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Gene/Protein Processing [8]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Gene/Protein Processing [8]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Gene/Protein Processing [8]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [8]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Gene/Protein Processing [9]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Gene/Protein Processing [10]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Protein Interaction/Cellular Processes [11]

References

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