Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKEG49)

Drug Name
Fenthion Drug Info
Synonyms
Baytex; ENT 25,540; Fenthion 4E; Fenthion [BAN]; Fenthion [BSI:ISO]; Fenthion-methyl; Fenthione; Figuron; Lebaycid; Lebayeid; MPP (pesticide); Mercaptophos; Mosquitocide 700; Phenthion; Pro-Spot; Queletox; S 1752; Spotton; Sulfidophos; Talodex; Tiguvon; fenthion; 4-Methylmercapto-3-methylphenyl dimethyl thiophosphate; 55-38-9; B 29493; BAY 29493; Bay-Bassa; Baycid; Bayer 29493; Bayer 9007; Bayer S-1752; BL0L45OVKT; C10H15O3PS2; CCRIS 310; Caswell No. 456F; EINECS 200-231-9; Entex; HSDB 1403; NCI-C08651; OMS 2; UNII-BL0L45OVKT
Cross-matching ID
PubChem CID
3346
ChEBI ID
CHEMBL34761
CAS Number
CAS 55-38-9
TTD Drug ID
DMKEG49
INTEDE Drug ID
DR1945

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [5]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [6]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [7]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [8]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [9]
Metronidazole DMTIVEN Abscess Approved [10]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [11]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [12]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [6]
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Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [20]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [25]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [29]
Quercetin DM3NC4M Obesity 5B81 Approved [30]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [31]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [26]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Selenium DM25CGV N. A. N. A. Approved [34]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [35]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Fructose DM43AN2 Vomiting MD90 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [43]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Selenium DM25CGV N. A. N. A. Approved [50]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [51]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [53]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [55]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
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Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [58]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [58]
Ethacrynic acid DM60QMR Edema MG29 Approved [62]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [64]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [58]
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Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [21]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [69]
Febuxostat DMDEXQ0 Hyperuricaemia 5C55.Y Approved [70]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [14]
Gefitinib DM15F0X Colon adenocarcinoma Approved [71]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [72]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [73]
Methotrexate DM2TEOL Anterior urethra cancer Approved [74]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [77]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
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Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
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Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [17]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [89]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [90]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [89]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [91]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [92]
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Drug(s) Affected By E3 ubiquitin-protein ligase RAD18 (RAD18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [61]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [94]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [95]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [96]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [97]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [98]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [99]
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Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [101]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [104]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [105]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [102]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [106]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2A6 (CYP2A6) Main DME DEJVYAZ CP2A6_HUMAN Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Gene/Protein Processing [2]
DNA repair protein XRCC2 OTJB2PV4 XRCC2_HUMAN Gene/Protein Processing [2]
E3 ubiquitin-protein ligase RAD18 (RAD18) OTQ9PLNT RAD18_HUMAN Gene/Protein Processing [2]
Flavin-containing monooxygenase 1 (FMO1) OTTHSQKP FMO1_HUMAN Biotransformations [3]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Gene/Protein Processing [4]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Gene/Protein Processing [2]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Gene/Protein Processing [4]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Gene/Protein Processing [4]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [4]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Gene/Protein Processing [4]

References

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59 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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61 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
62 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
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