Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNMXR8)

Drug Name
Procainamide Drug Info
Synonyms
Biocoryl; Novocainamid; Novocainamide; Novocamid; Procainamida; Procainamidum; Procamide; Procan; Procanbid; Procapan; Pronestyl; Novocaine amide; Procaine amide; P-Aminobenzoic diethylaminoethylamide; Procainamida [INN-Spanish]; Procainamide (INN); Procainamide [INN:BAN]; Procainamidum [INN-Latin]; Procan (TN); Procanbid (TN); Procapan (free base); Pronestyl (TN); Pronestyl-Sr; P-Amino-N-(2-diethylaminoethyl)benzamide; Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-(9CI); 2-Diethylaminoethylamid kyseliny p-aminobenzoove; 2-Diethylaminoethylamid kyseliny p-aminobenzoove [Czech]; 4-Amino-N-(2-(Diethylamino)Ethyl)Benzamide Sulfate; 4-Amino-N-(2-(diethylamino)ethyl)benzamide; 4-Amino-N-[2-(diethylamino)ethyl]benzamide; 4-amino-N-(2-diethylaminoethyl)-benzamide; 4-amino-N-(2-diethylaminoethyl)benzamide
Indication
Disease Entry ICD 11 Status REF
Ventricular arrhythmias BC71 Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Cross-matching ID
PubChem CID
4913
ChEBI ID
CHEMBL640
CAS Number
CAS 51-06-9
TTD Drug ID
DMNMXR8
VARIDT Drug ID
DR00292
INTEDE Drug ID
DR1343

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting E3 ubiquitin-protein ligase COP1 (RFWD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [2]
Propafenone DMPIBJK Tachyarrhythmias BC71 Approved [2]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [2]
Tocainide DMYNMDP Ventricular arrhythmias BC71 Approved [2]
Barucainide DMTMS3L Heart arrhythmia BC65 Terminated [13]
Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [4]
Metformin DM89QE1 Colorectal carcinoma Approved [14]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [4]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [4]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [15]
Topotecan DMP6G8T Central nervous system neoplasm Approved [4]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [16]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [17]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [18]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [19]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [26]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [27]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [28]
Propranolol DM79NTF Angina pectoris BA40 Approved [29]
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Drug(s) Transported By Multidrug and toxin extrusion protein 2 (SLC47A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [4]
Metformin DM89QE1 Colorectal carcinoma Approved [4]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [4]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [4]
Topotecan DMP6G8T Central nervous system neoplasm Approved [4]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [17]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [18]
Estrone sulfate DMVBIZL Atrophic vaginitis GA30.2 Approved [4]
N-methylpyridinium DMVUKEW N. A. N. A. Preclinical [4]
[14C]TEA DM6SFYH Discovery agent N.A. Investigative [4]
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Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [30]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [31]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [32]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [33]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [34]
Mesalazine DMOL5IU Diverticulitis Approved [35]
Allopurinol DMLPAOB Gout FA25 Approved [36]
Netilmicin DMRD1QK Bacterial infection 1A00-1C4Z Approved [37]
Clonazepam DMTO13J Absence epilepsy Approved [38]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [39]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [45]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [46]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [47]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [48]
Propranolol DM79NTF Angina pectoris BA40 Approved [49]
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Drug(s) Metabolized By N-acetyltransferase 1 (NAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [50]
Amifampridine DMK08L3 LambertEaton myasthenic syndrome 8C62 Approved [51]
Asacolitin DM3WVPJ N. A. N. A. Investigative [52]
Drug(s) Metabolized By N-acetyltransferase 2 (NAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [53]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [54]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [50]
Amifampridine DMK08L3 LambertEaton myasthenic syndrome 8C62 Approved [51]
Asacolitin DM3WVPJ N. A. N. A. Investigative [52]
Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Testosterone DM7HUNW Hot flushes GA30 Approved [60]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [63]
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [64]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Prednisone DM2HG4X Acute asthma CA23 Approved [67]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [73]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [74]
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Drug(s) Affected By Ras association domain-containing protein 1 (RASSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [75]
Quercetin DM3NC4M Obesity 5B81 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Folic Acid DMEMBJC Colorectal carcinoma Approved [80]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [81]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [82]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [83]
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Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [11]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [84]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [85]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Meloxicam DM2AR7L Arthritis FA20 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [89]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Retigabine DMGNYIH Behcet disease 4A62 Approved [91]
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Drug(s) Affected By N-alpha-acetyltransferase 20 (NAA20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [93]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [94]
Arsenic DMTL2Y1 N. A. N. A. Approved [95]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [11]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [11]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [96]
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Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [98]
Pentobarbital DMFNH7L Brain ischaemia 8B1Z Approved [99]
Verapamil DMA7PEW Angina pectoris BA40 Approved [11]
Propranolol DM79NTF Angina pectoris BA40 Approved [11]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [11]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [11]
Quinidine DMLPICK N. A. N. A. Approved [11]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [11]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
E3 ubiquitin-protein ligase COP1 (RFWD2) TT05DLS COP1_HUMAN Modulator [2]
Voltage-gated sodium channel (Nav) TTIG65Q NOUNIPROTAC Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [3]
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [4]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
N-acetyltransferase 1 (NAT1) DE7OAB3 ARY1_HUMAN Substrate [6]
RNA cytidine acetyltransferase (hALP) DEZV4AP NAT10_HUMAN Substrate [7]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Biotransformations [9]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Gene/Protein Processing [10]
N-alpha-acetyltransferase 20 (NAA20) OTJB0VA6 NAA20_HUMAN Drug Response [11]
Potassium voltage-gated channel subfamily E member 1 (KCNE1) OTZNQUW9 KCNE1_HUMAN Drug Response [11]
Ras association domain-containing protein 1 (RASSF1) OTEZIPB7 RASF1_HUMAN Gene/Protein Processing [10]
Sodium channel protein type 5 subunit alpha (SCN5A) OTGYZWR6 SCN5A_HUMAN Drug Response [11]
WD repeat domain phosphoinositide-interacting protein 1 OTV2NPHG WIPI1_HUMAN Gene/Protein Processing [12]

References

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35 NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis. Z Gastroenterol. 2008 Mar;46(3):259-65.
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37 Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother. 2003 May;47(5):1577-83.
38 Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5.
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42 CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
43 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
44 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
45 Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
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50 N-acetyltransferase 2 genotype-dependent N-acetylation of hydralazine in human hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281.
51 Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099.
52 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
53 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
54 Importance of the evaluation of N-acetyltransferase enzyme activity prior to 5-aminosalicylic acid medication for ulcerative colitis. Inflamm Bowel Dis. 2016 Aug;22(8):1793-802.
55 Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochem Pharmacol. 2005 Jan 15;69(2):347-59. doi: 10.1016/j.bcp.2004.09.014. Epub 2004 Nov 24.
56 Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics. 2010 Jul;11(7):951-8. doi: 10.2217/pgs.10.65.
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58 The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
59 Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Clin Exp Pharmacol Physiol. 2009 Aug;36(8):828-33.
60 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
61 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
62 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
63 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
64 Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines. Toxicol Sci. 2022 Nov 23;190(2):158-172. doi: 10.1093/toxsci/kfac103.
65 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
66 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
67 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
68 A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
69 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
70 Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):219-29. doi: 10.1016/j.taap.2005.12.015. Epub 2006 Feb 21.
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