Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPGHY8)

Drug Name
Roflumilast Drug Info
Synonyms
162401-32-3; DAXAS; Daliresp; 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLOROPYRIDIN-4-YL)-4-(DIFLUOROMETHOXY)BENZAMIDE; BY217; BYK20869; UNII-0P6C6ZOP5U; BY-217; Roflumilast (Daxas); B9302-107; 0P6C6ZOP5U; 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-; CHEMBL193240; CHEBI:47657; BYK-20869; ROF; Libertek; AK110425; 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide; DAXAS; Roflumilast [USAN]; APTA-2217; Roflumilast (JAN/USAN/INN); 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-di-chloropyrid-4-yl)benzamide; Alogliptin/roflumilast
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Approved [1]
Type-2 diabetes 5A11 Phase 1 [2]
Chronic obstructive pulmonary disease CA22 Withdrawn from market [1]
Atopic dermatitis EA80 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
449193
ChEBI ID
CHEBI:47657
CAS Number
CAS 162401-32-3
TTD Drug ID
DMPGHY8
INTEDE Drug ID
DR1434
ACDINA Drug ID
D00604

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Phosphodiesterase 4 (PDE4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [7]
Oxtriphylline DMLHSE3 Cough MD12 Approved [8]
Ibudilast DM4LSPN Castleman's disease 4B2Y Approved [9]
crisaborole DMNVKU6 Atopic dermatitis EA80 Approved [10]
Arofylline DM84AD1 Chronic obstructive pulmonary disease CA22 Phase 3 [11]
ARQ-151 DML61S4 Atopic dermatitis EA80 Phase 3 [12]
SUN13834 DMPK34E Gram-positive bacterial infection 1B74-1G40 Phase 2 [13]
ONO-6126 DMRT28X Chronic obstructive pulmonary disease CA22 Phase 2 [11]
E6005 DM1S489 Atopic dermatitis EA80 Phase 2 [14]
IC-485 DMB1UYV Chronic obstructive pulmonary disease CA22 Phase 2 [11]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [15]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [16]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [17]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [18]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [19]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [20]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [16]
Verapamil DMA7PEW Angina pectoris BA40 Approved [23]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [24]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [28]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [21]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [30]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
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Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [37]
Trequinsin DMQRSMD N. A. N. A. Terminated [5]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [38]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [39]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [40]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [47]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [48]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [51]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [53]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [54]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [55]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [58]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [59]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [61]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [65]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [70]
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Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Folic Acid DMEMBJC Colorectal carcinoma Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [75]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [76]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [77]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [78]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [37]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [81]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [82]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [83]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [84]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [85]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [86]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [87]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [88]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [60]
Selenium DM25CGV N. A. N. A. Approved [90]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [91]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [92]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [96]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [97]
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Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [100]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [101]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [102]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [104]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [105]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [106]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [107]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [51]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [108]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [109]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Meloxicam DM2AR7L Arthritis FA20 Approved [112]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [113]
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Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4C (PDE4C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [115]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Arsenic DMTL2Y1 N. A. N. A. Approved [116]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [117]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [118]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [119]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [120]
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Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [38]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Panobinostat DM58WKG Chronic graft versus host disease Approved [77]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [103]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [115]
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Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (PDE3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [126]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [127]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [120]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [77]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [128]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [37]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [129]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [130]
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Drug(s) Affected By High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Bortezomib DMNO38U Leukemia Approved [131]
Arsenic DMTL2Y1 N. A. N. A. Approved [132]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [76]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [37]
Trequinsin DMQRSMD N. A. N. A. Terminated [5]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [38]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [77]
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Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [133]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [133]
Leflunomide DMR8ONJ Arthritis FA20 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [124]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [134]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [135]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Arsenic DMTL2Y1 N. A. N. A. Approved [136]
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Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [137]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [138]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [90]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [139]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [140]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Phosphodiesterase 4 (PDE4) TTV5CGO NOUNIPROTAC Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 1A2 (CYP1A2) Main DME DEJGDUW CP1A2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3',5'-cyclic-AMP phosphodiesterase 4A (PDE4A) OTMUUZLF PDE4A_HUMAN Gene/Protein Processing [5]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Gene/Protein Processing [5]
3',5'-cyclic-AMP phosphodiesterase 4C (PDE4C) OTI8VMHZ PDE4C_HUMAN Gene/Protein Processing [5]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Gene/Protein Processing [5]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [6]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [6]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Gene/Protein Processing [5]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (PDE3B) OT1GI1TE PDE3B_HUMAN Gene/Protein Processing [5]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [6]

References

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