Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ2FKJ)

Drug Name
Teriflunomide Drug Info
Indication
Disease Entry ICD 11 Status REF
Hyperlipidaemia 5C80 Approved [1]
Lupus nephritis 4A40.0Y Approved [2]
Multiple sclerosis 8A40 Approved [3]
Psoriatic arthritis FA21 Approved [2]
Rheumatoid arthritis FA20 Phase 3 [3]
Hepatitis B virus infection 1E51.0 Phase 1 [1]
Cross-matching ID
PubChem CID
54684141
ChEBI ID
CHEMBL973
CAS Number
CAS 163451-81-8
TTD Drug ID
DMQ2FKJ
VARIDT Drug ID
DR00092
ACDINA Drug ID
D00665

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [11]
Leflunomide DMR8ONJ Arthritis FA20 Approved [12]
Atovaquone DMY4UMW Fungal infection 1F29-1F2F Approved [13]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [14]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [15]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [15]
Orotate DMMB29S Discovery agent N.A. Investigative [16]
Lauryl Dimethylamine-N-Oxide DM3W2OE Discovery agent N.A. Investigative [15]
1,4-Naphthoquinone DMTCMH7 Discovery agent N.A. Investigative [14]
Dihydroorotate DM76BGZ Discovery agent N.A. Investigative [17]
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Drug(s) Targeting HMG-CoA reductase (HMGCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [18]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [19]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [20]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [21]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [22]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [19]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [19]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [23]
TOCOTRIENOL DM1UE67 Hyperlipidaemia 5C80 Approved [24]
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Drug(s) Targeting Dihydroorotate dehydrogenase (DHODH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vidofludimus DM0POWG Inflammatory bowel disease DD72 Phase 2 [25]
BREQUINAR DMKGM42 Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [26]
BAY2402234 DMRL6W5 Myeloid leukaemia 2B33.1 Phase 1 [27]
LAS-186323 DMV80DP Multiple sclerosis 8A40 Phase 1 [28]
HR325 DM51GZS Rheumatoid arthritis FA20 Discontinued in Phase 2 [29]
FK778 DMH6QAI Kidney/heart transplant rejection NE84 Discontinued in Phase 2 [30]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Folic Acid DMEMBJC Colorectal carcinoma Approved [33]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [36]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [38]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [39]
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Drug(s) Affected By Ornithine aminotransferase, mitochondrial (OAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Panobinostat DM58WKG Chronic graft versus host disease Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [45]
Folic Acid DMEMBJC Colorectal carcinoma Approved [46]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
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Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [45]
Isoproterenol DMK7MEY Atrioventricular block Approved [55]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [56]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Selenium DM25CGV N. A. N. A. Approved [60]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [63]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
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Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Calcidiol DMN4CV5 Hypophosphatemia Approved [67]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [73]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
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Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [78]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [82]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [83]
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Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [86]
Arsenic DMTL2Y1 N. A. N. A. Approved [87]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [88]
Urethane DM7NSI0 N. A. N. A. Phase 4 [89]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [90]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [91]
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Drug(s) Affected By Mitochondrial fission regulator 2 (MTFR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Testosterone DM7HUNW Hot flushes GA30 Approved [75]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [75]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [93]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [94]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [95]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [96]
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Drug(s) Affected By Choline dehydrogenase, mitochondrial (CHDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [98]
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [95]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [101]
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Drug(s) Affected By Dimethyladenosine transferase 1, mitochondrial (TFB1M)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [45]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Arsenic DMTL2Y1 N. A. N. A. Approved [87]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [88]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [102]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Urethane DM7NSI0 N. A. N. A. Phase 4 [89]
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Drug(s) Affected By Probable ATP-dependent RNA helicase DDX28 (DDX28)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [106]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [43]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [107]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [107]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [88]
Urethane DM7NSI0 N. A. N. A. Phase 4 [89]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [108]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [109]
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Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [112]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [114]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Fluoxetine DM3PD2C Bipolar depression Approved [115]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [116]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [113]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [116]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [116]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [117]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [120]
Artemether DM48QOT Malaria 1F40-1F45 Approved [121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [122]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [123]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [124]
Estrone DM5T6US Acne vulgaris ED80 Approved [125]
Leflunomide DMR8ONJ Arthritis FA20 Approved [10]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [92]
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Drug(s) Affected By Glycophorin-A (GYPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [127]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [128]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [129]
Arsenic DMTL2Y1 N. A. N. A. Approved [130]
Allopurinol DMLPAOB Gout FA25 Approved [131]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [132]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [133]
APIGENIN DMI3491 Discovery agent N.A. Investigative [134]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [135]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [136]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Gefitinib DM15F0X Colon adenocarcinoma Approved [138]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [139]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [140]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [141]
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [145]
Selenium DM25CGV N. A. N. A. Approved [146]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [149]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [151]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
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Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [142]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [156]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [157]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [158]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [149]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [159]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [160]
Gefitinib DM15F0X Colon adenocarcinoma Approved [161]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [139]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Etretinate DM2CZFA Keratosis ED56 Approved [163]
Prednisone DM2HG4X Acute asthma CA23 Approved [164]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [165]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [153]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [166]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [167]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [167]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [168]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [169]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [167]
Ethacrynic acid DM60QMR Edema MG29 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
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Drug(s) Affected By Interleukin-10 receptor subunit alpha (IL10RA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [170]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [93]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [170]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [85]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [47]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [86]
Arsenic DMTL2Y1 N. A. N. A. Approved [87]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [172]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dihydroorotate dehydrogenase (DHODH) TTLVP78 PYRD_HUMAN Modulator [4]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [1]
Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase) TT3PQ2Y PYRD_PLAF7 Inhibitor [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [7]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Gene/Protein Processing [7]
Choline dehydrogenase, mitochondrial (CHDH) OTO2DPGL CHDH_HUMAN Gene/Protein Processing [7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [8]
Dimethyladenosine transferase 1, mitochondrial (TFB1M) OTFCUSAZ TFB1M_HUMAN Gene/Protein Processing [7]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Gene/Protein Processing [9]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Gene/Protein Processing [10]
Glycophorin-A (GYPA) OTABU4YV GLPA_HUMAN Gene/Protein Processing [8]
Heat shock 70 kDa protein 1-like (HSPA1L) OTC2V1K6 HS71L_HUMAN Gene/Protein Processing [7]

References

1 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
2 Teriflunomide FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6844).
4 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
5 Expression and characterization of E. coli-produced soluble, functional human dihydroorotate dehydrogenase: a potential target for immunosuppression. J Mol Microbiol Biotechnol. 1999 Aug;1(1):183-8.
6 MDR-ABC transporters: biomarkers in rheumatoid arthritis. Clin Exp Rheumatol. 2013 Sep-Oct;31(5):779-87.
7 Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
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