Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSIVND)

• Drug Name: Hydroxychloroquine Drug Info
• Synonyms: Hidroxicloroquina; Hidroxicloroquina [INN-Spanish]; Hydroxychlorochin; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hydroxychloroguine; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquine Sulfate (1:1) Salt; Hydroxychloroquinum; Hydroxychloroquinum [INN-Latin]; Idrossiclorochina; Idrossiclorochina [DCIT]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Plaquenil (TN); Polirreumin; Polirreumin (TN); Quensyl; WIN 1258

Indication

Disease Entry	ICD 11	Status	REF
Chronic renal failure	GB61.Z	Approved	[1]
Malaria	1F40-1F45	Approved	[2]
Plasmodium falciparum malaria	1F40	Approved	[1]
Plasmodium malariae malaria		Approved	[1]
Plasmodium ovale malaria		Approved	[1]
Systemic lupus erythematosus	4A40.0	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
Colon cancer	2B90.Z	Investigative	[1]

• Therapeutic Class: Antimalarials
• Cross-matching ID:
  PubChem CID: 3652
  ChEBI ID: CHEBI:5801
  CAS Number: CAS 118-42-3
  TTD Drug ID: DMSIVND
  VARIDT Drug ID: DR00449
  INTEDE Drug ID: DR0837
  ACDINA Drug ID: D00316

Molecule-Related Drug Atlas

Drug(s) Targeting HUMAN pH-dependent viral fusion/replication (pH-DVF/R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[5]

Drug(s) Targeting HUMAN glycosylation of host receptor (GHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[5]

Drug(s) Targeting Toll-like receptor 7 (TLR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[15]
ANA773	DMSC8YW	Hepatitis C virus infection	1E51.1	Phase 2a	[16]
GS-9620	DMG5C8D	Hepatitis B virus infection	1E51.0	Phase 2	[17]
IMO-3100	DMM549D	Psoriasis vulgaris	EA90	Phase 2	[18]
Resiquimod	DML6XSP	Actinic keratosis	EK90.0	Phase 2	[19]
LOXORIBINE	DMIV9ZE	Immune System disease	4A01-4B41	Phase 2	[20]
GSK2245035	DMBWPZJ	Asthma	CA23	Phase 2	[21]
AZD-8848	DM0M7QW	Allergic rhinitis	CA08.0	Phase 2	[22]
Isatoribine	DMHOJ8W	Hepatitis C virus infection	1E51.1	Phase 2	[23]
PF-4878691	DM24I0N	Melanoma	2C30	Phase 2	[24]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[32]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[33]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[41]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[35]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[44]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[47]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[48]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[49]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[50]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[51]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[52]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[53]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[70]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[71]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[78]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[79]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[75]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[88]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[89]

Drug(s) Affected By Claudin-1 (CLDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[98]

Drug(s) Affected By Interferon beta (IFNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[103]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[103]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[104]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[105]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[106]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[107]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[114]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[116]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]

Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[128]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[131]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]
Fructose	DM43AN2	Vomiting	MD90	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[155]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[156]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[157]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[160]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[164]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[162]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[166]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[169]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[170]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[119]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[177]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[179]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[182]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[183]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[184]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[185]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[82]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[186]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[187]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[185]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[190]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[191]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[192]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[174]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[202]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[203]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[205]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[206]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[209]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[210]

Drug(s) Affected By TNF receptor-associated factor 3 (TRAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[82]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[212]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[186]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[85]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[218]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[223]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]

Drug(s) Affected By Interferon regulatory factor 3 (IRF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[226]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[89]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[228]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[233]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[234]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[237]

Drug(s) Affected By Mitochondrial antiviral-signaling protein (MAVS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[88]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[53]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[240]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[59]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[102]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]

Drug(s) Affected By Toll-like receptor 9 (TLR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[244]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[245]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[235]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 7 (TLR7)	TTRJ1K4	TLR7_HUMAN	Antagonist	[4]
HUMAN glycosylation of host receptor (GHR)	TTZGK1R	.	Inhibitor	[5]
HUMAN pH-dependent viral fusion/replication (pH-DVF/R)	TTD16BI	.	Inhibitor	[5]
HUMAN toll-like receptor 7/9 signalling pathway (TLR7/9 pathway)	TT3A1EZ	.	Inhibitor	[6]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[9]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[9]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[10]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Gene/Protein Processing	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[11]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[12]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Gene/Protein Processing	[13]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Gene/Protein Processing	[14]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[14]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Protein Interaction/Cellular Processes	[11]

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