Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUXQG7)

Drug Name
Phosphate Drug Info
Synonyms
orthophosphate; Phosphate ion; 14265-44-2; O-Phosphate; UNII-NK08V8K8HR; NK08V8K8HR; Phosphates; Phosphate ions; PO4; a phosphate group; tetraoxophosphate(V); tetraoxophosphate(3-); Phosphoric acid trianion; tetraoxidophosphate(3-); phosphoric acid, ion(3-); AC1L1AN2; DTXSID7039672; CHEBI:18367; CTK0H5978; NBIIXXVUZAFLBC-UHFFFAOYSA-K; BDBM50155537; AKOS015903596; PO4(3-); CREATINE PHOSPHATE; N-PHOSPHOCREATINE; [PO4](3-); I14-18227
Indication
Disease Entry ICD 11 Status REF
Constipation DD91.1 Approved [1]
Cross-matching ID
PubChem CID
1061
ChEBI ID
CHEBI:18367
CAS Number
CAS 14265-44-2
TTD Drug ID
DMUXQG7
VARIDT Drug ID
DR00132
INTEDE Drug ID
DR2121

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Sodium-dependent phosphate transport protein 1 (SLC17A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [7]
Drug(s) Transported By Sodium-dependent phosphate transport protein 4 (SLC17A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AMINOHIPPURIC ACID DMUN54G Discovery agent N.A. Investigative [12]
Drug(s) Transported By Probable small intestine urate exporter (SLC17A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [11]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [11]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [11]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [11]
Drug(s) Transported By Vesicular glutamate transporter 2 (SLC17A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [22]
Drug(s) Transported By Vesicular glutamate transporter 1 (SLC17A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [22]
Drug(s) Transported By Mitochondrial dicarboxylate carrier (SLC25A10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SULFATE DMW0ZBF Discovery agent N.A. Investigative [2]
Drug(s) Transported By Glycerol-3-phosphate permease (SLC37A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glucose-6-Phosphate DMKY1L4 N. A. N. A. Phase 1 [10]
Drug(s) Metabolized By GDP-D-glucose phosphorylase 1 (GDPGP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GDP-alpha-D-glucose DMF6MUB N. A. N. A. Investigative [13]
Drug(s) Affected By Sodium-dependent phosphate transporter 2 (SLC20A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [25]
Testosterone DM7HUNW Hot flushes GA30 Approved [26]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [31]
Arsenic DMTL2Y1 N. A. N. A. Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [36]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [37]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [38]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parathyroid hormone (PTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [40]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [41]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [42]
Arsenic DMTL2Y1 N. A. N. A. Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [45]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [46]
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Drug(s) Affected By Steryl-sulfatase (STS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [47]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [49]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [50]
Danazol DML8KTN Menorrhagia GA20.50 Approved [51]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [49]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [47]
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Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [52]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [53]
Quercetin DM3NC4M Obesity 5B81 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [60]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [61]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [63]
Gefitinib DM15F0X Colon adenocarcinoma Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [68]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [69]
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Drug(s) Affected By Phosphate-regulating neutral endopeptidase PHEX (PHEX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [70]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [71]
Glycerol-2-Phosphate DM0J5KF Discovery agent N.A. Investigative [72]
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [74]
Gefitinib DM15F0X Colon adenocarcinoma Approved [75]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [78]
Methotrexate DM2TEOL Anterior urethra cancer Approved [79]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [80]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dentin matrix acidic phosphoprotein 1 (DMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [82]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Folic Acid DMEMBJC Colorectal carcinoma Approved [84]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [87]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [88]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [89]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [18]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [90]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [92]
Sorbitol DMAN0DE Constipation DD91.1 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [30]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [93]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [94]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [95]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 23 (FGF23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [96]
Pamidronate DMB4AVP Bone Paget disease Approved [97]
Arsenic DMTL2Y1 N. A. N. A. Approved [98]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [96]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [83]
Glycerol-2-Phosphate DM0J5KF Discovery agent N.A. Investigative [17]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [99]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [100]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [101]
Fructose DM43AN2 Vomiting MD90 Approved [45]
Ketoprofen DMRKXPT Bursitis Approved [45]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [102]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [103]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [104]
Gefitinib DM15F0X Colon adenocarcinoma Approved [105]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
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Drug(s) Affected By Matrix extracellular phosphoglycoprotein (MEPE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [108]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [109]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [110]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Mitochondrial dicarboxylate carrier (SLC25A10) DTJYKDQ DIC_HUMAN Substrate [2]
Phosphate carrier protein (SLC25A3) DTCRIWV MPCP_HUMAN Substrate [3]
Calcium-binding mitochondrial carrier protein SCaMC-3 (SLC25A23) DTLQ0EZ SCMC3_HUMAN Substrate [4]
Sodium-dependent phosphate transporter 2 (SLC20A2) DTFD4VB S20A2_HUMAN Substrate [5]
Sodium-dependent phosphate transporter 1 (SLC20A1) DTMULXV S20A1_HUMAN Substrate [5]
Vesicular glutamate transporter 1 (SLC17A7) DTNK0FR VGLU1_HUMAN Substrate [6]
Vesicular glutamate transporter 2 (SLC17A6) DT5LHCR VGLU2_HUMAN Substrate [7]
Calcium-binding mitochondrial carrier protein SCaMC-2 (SLC25A25) DTN7X5J SCMC2_HUMAN Substrate [8]
Calcium-binding mitochondrial carrier protein SCaMC-1 (SLC25A24) DTVAEDK SCMC1_HUMAN Substrate [9]
Glycerol-3-phosphate permease (SLC37A1) DTH9SQJ G6PT2_HUMAN Substrate [10]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [11]
Sodium-dependent phosphate transport protein 4 (SLC17A3) DTFOJL7 NPT4_HUMAN Substrate [12]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Substrate [7]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
GDP-D-glucose phosphorylase 1 (GDPGP1) Main DME DE9P5K7 GDPP1_HUMAN Substrate [13]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Bone morphogenetic protein 2 (BMP2) OT23T37S BMP2_HUMAN Gene/Protein Processing [14]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Protein Interaction/Cellular Processes [15]
Dentin matrix acidic phosphoprotein 1 (DMP1) OTBWBWW7 DMP1_HUMAN Gene/Protein Processing [16]
Fibroblast growth factor 23 (FGF23) OTZT523D FGF23_HUMAN Gene/Protein Processing [17]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Gene/Protein Processing [18]
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) OTGBRJDQ MKNK1_HUMAN Gene/Protein Processing [19]
Matrix extracellular phosphoglycoprotein (MEPE) OTXJRUW0 MEPE_HUMAN Regulation of Drug Effects [20]
Parathyroid hormone (PTH) OTD721UF PTHY_HUMAN Gene/Protein Processing [21]
Phosphate-regulating neutral endopeptidase PHEX (PHEX) OTG7N3J7 PHEX_HUMAN Gene/Protein Processing [17]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Gene/Protein Processing [15]

References

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2 SLC25A10 biallelic mutations in intractable epileptic encephalopathy with complex I deficiency. Hum Mol Genet. 2018 Feb 1;27(3):499-504.
3 The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. J Biol Chem. 2018 Feb 9;293(6):1887-1896.
4 Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family. Gene. 2005 Jan 31;345(2):173-82.
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8 Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis. Sci Rep. 2017 Jun 6;7(1):2885.
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13 A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. J Biol Chem. 2011 Jun 17;286(24):21511-23.
14 Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR. J Pharmacol Exp Ther. 2020 Mar;372(3):277-284. doi: 10.1124/jpet.119.263160. Epub 2019 Dec 16.
15 High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLoS One. 2013;8(1):e53393. doi: 10.1371/journal.pone.0053393. Epub 2013 Jan 4.
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40 Normalization of lithium-induced hypercalcemia and hyperparathyroidism with cinacalcet hydrochloride. Am J Kidney Dis. 2006 Nov;48(5):832-7. doi: 10.1053/j.ajkd.2006.07.019.
41 Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS One. 2010 Dec 13;5(12):e15235. doi: 10.1371/journal.pone.0015235.
42 Phenytoin induced vitamin D deficiency presenting as proximal muscle weakness. Indian Pediatr. 2010 Jul;47(7):624-5. doi: 10.1007/s13312-010-0121-3.
43 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
44 Paricalcitol versus calcitriol in the treatment of secondary hyperparathyroidism. Kidney Int. 2003 Apr;63(4):1483-90. doi: 10.1046/j.1523-1755.2003.00878.x.
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46 A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer. Br J Cancer. 1998 Jul;78(1):6-13. doi: 10.1038/bjc.1998.434.
47 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
48 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
49 Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. J Cell Biochem. 2006 Feb 1;97(2):327-50. doi: 10.1002/jcb.20579.
50 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
51 Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. Eur J Med Chem. 2001 Jul-Aug;36(7-8):659-71. doi: 10.1016/s0223-5234(01)01262-4.
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