Details of Disease

General Information of Disease (ID: DIS7CAJA)

• Disease Name: Interstitial cystitis
• Synonyms: interstitial cystitis/painful bladder syndrome; ulcerative cystitis; painful bladder syndrome; IC/PBS; chronic interstitial cystitis; interstitial cystitis/bladder pain syndrome; interstitial cystitis, chronic; bladder pain syndrome; IC/BPS
• Disease Class: GC00: Cystitis
• Definition: A rare chronic debilitating urogenital disease characterized by urinary frequency, urgency, and pelvic pain.
• Disease Hierarchy:
  DISKXBS3: Connective tissue disorder
  DISRWHDG: Chronic cystitis
  DIS7CAJA: Interstitial cystitis
• ICD Code:
  ICD-11: ICD-11: GC00.3
  ICD-10: ICD-10: N30.1
  Expand ICD-11: 'GC00.3
  Expand ICD-10: 'N30.1
• Disease Identifiers:
  MONDO ID: MONDO_0018301
  MESH ID: D018856
  UMLS CUI: C0282488
  MedGen ID: 129176
  Orphanet ID: 37202
  SNOMED CT ID: 111409009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Dimethyl Sulfoxide	DMX3ZFP	Approved	Small molecular drug	[1]
Lidocaine	DML4ZOT	Approved	Small molecular drug	[2]
Mycophenolate mofetil	DMPQAGE	Approved	Small molecular drug	[3]
Mycophenolic acid	DMRBMAU	Approved	NA	[4]
Pentosan Polysulfate	DM2HRKE	Approved	Small molecular drug	[5]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PSD-597	DM01POQ	Discontinued in Phase 2	NA	[6]

This Disease is Treated as An Indication in 2 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CEL-021	DMGM7VN	Investigative	NA	[7]
TTI-1612	DMAIN33	Investigative	NA	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 12 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CXCL11	TTWG0RE	Limited	Biomarker	[8]
CXCL9	TTWE5PB	Limited	Biomarker	[8]
ADRA1D	TT34BHT	Strong	Biomarker	[9]
AOAH	TT2EJXQ	Strong	Biomarker	[10]
ASIC1	TTRJYB6	Strong	Biomarker	[11]
CXCL10	TTQOVYA	Strong	Biomarker	[12]
FFAR4	TT08JVB	Strong	Biomarker	[13]
FGF10	TTNPEFX	Strong	Biomarker	[14]
LPAR4	TT7ZMY4	Strong	Biomarker	[15]
MKNK1	TTEZAUX	Strong	Altered Expression	[16]
SCN9A	TT4G2JS	Strong	Genetic Variation	[17]
TPSD1	TTNWD8O	Strong	Altered Expression	[18]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
SMOX	DEOH5V3	Strong	Biomarker	[19]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BTBD8	OT3A3RD7	Strong	Biomarker	[20]
ELAVL3	OTI2VI8B	Strong	Biomarker	[21]
FZD8	OTZ9IRFL	Strong	Biomarker	[22]
MAP1LC3A	OTPMGIU4	Strong	Altered Expression	[23]
MDFIC	OTSRYBWZ	Strong	Biomarker	[24]
NAP1L1	OTI7WBZV	Strong	Altered Expression	[25]
P3H4	OTZPXYSH	Strong	Biomarker	[26]
POLR2E	OTH5IL2A	Strong	Biomarker	[27]
SMARCC2	OTC5SNMZ	Strong	Altered Expression	[28]
TNFAIP6	OT1SLUZH	Strong	Biomarker	[29]

References

• [1] Dimethyl Sulfoxide FDA Label
• [2] Lidocaine FDA Label
• [3] Mycophenolate mofetil FDA Label
• [4] Early termination of a trial of mycophenolate mofetil for treatment of interstitial cystitis/painful bladder syndrome: lessons learned. J Urol. 2011 Mar;185(3):901-6.
• [5] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020193.
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024201)
• [7] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [8] CXCL10 blockade protects mice from cyclophosphamide-induced cystitis.J Immune Based Ther Vaccines. 2008 Oct 28;6:6. doi: 10.1186/1476-8518-6-6.
• [9] Molecular analysis of adrenergic receptor genes and interleukin-4/interleukin-4 receptor genes in patients with interstitial cystitis.J Urol. 2002 Dec;168(6):2668-71. doi: 10.1016/S0022-5347(05)64241-3.
• [10] Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor.Am J Physiol Regul Integr Comp Physiol. 2019 Aug 1;317(2):R289-R300. doi: 10.1152/ajpregu.00029.2019. Epub 2019 Apr 24.
• [11] Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis.J Urol. 2013 Nov;190(5):1925-31. doi: 10.1016/j.juro.2013.05.049. Epub 2013 May 28.
• [12] Diagnostic value of urinary CXCL10 as a biomarker for predicting Hunner type interstitial cystitis.Neurourol Urodyn. 2018 Mar;37(3):1113-1119. doi: 10.1002/nau.23431. Epub 2017 Oct 19.
• [13] Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.Mol Med. 2018 Nov 27;24(1):60. doi: 10.1186/s10020-018-0062-1.
• [14] FGF-10 and its receptor exhibit bidirectional paracrine targeting to urothelial and smooth muscle cells in the lower urinary tract.Am J Physiol Renal Physiol. 2006 Aug;291(2):F481-94. doi: 10.1152/ajprenal.00025.2006. Epub 2006 Apr 4.
• [15] Microrna-139-5p inhibits epithelial-mesenchymal transition and fibrosis in post-menopausal women with interstitial cystitis by targeting LPAR4 via the PI3K/Akt signaling pathway.J Cell Biochem. 2018 Aug;119(8):6429-6441. doi: 10.1002/jcb.26610. Epub 2018 May 10.
• [16] Differentiation associated changes in gene expression profiles of interstitial cystitis and control urothelial cells.J Urol. 2008 Dec;180(6):2681-7. doi: 10.1016/j.juro.2008.08.007. Epub 2008 Oct 31.
• [17] Polymorphism in the SCN9A voltage-gated sodium channel gene associated with interstitial cystitis/bladder pain syndrome.Urology. 2013 Jan;81(1):210.e1-4. doi: 10.1016/j.urology.2012.07.072. Epub 2012 Oct 24.
• [18] Angiogenesis in bladder tissues is strongly correlated with urinary frequency and bladder pain in patients with interstitial cystitis/bladder pain syndrome.Int J Urol. 2019 Jun;26 Suppl 1:35-40. doi: 10.1111/iju.13972.
• [19] Pseudomonas aeruginosa induces apoptosis in human endothelial cells.Microb Pathog. 2000 Dec;29(6):345-56. doi: 10.1006/mpat.2000.0400.
• [20] Intracranial and Extracranial Injury Burden as Drivers of Impaired Cerebrovascular Reactivity in Traumatic Brain Injury.J Neurotrauma. 2018 Jul 15;35(14):1569-1577. doi: 10.1089/neu.2017.5595.
• [21] Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway.Biochem Biophys Res Commun. 2018 Jan 1;495(1):546-552. doi: 10.1016/j.bbrc.2017.11.072. Epub 2017 Nov 11.
• [22] Quantitative proteomics identifies a beta-catenin network as an element of the signaling response to Frizzled-8 protein-related antiproliferative factor.Mol Cell Proteomics. 2011 Jun;10(6):M110.007492. doi: 10.1074/mcp.M110.007492. Epub 2011 Mar 21.
• [23] Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model.Stem Cell Res Ther. 2017 May 8;8(1):107. doi: 10.1186/s13287-017-0547-9.
• [24] Comparison of inflammatory urine markers in patients with interstitial cystitis and overactive bladder.Int Urogynecol J. 2018 Jul;29(7):961-966. doi: 10.1007/s00192-017-3547-5. Epub 2018 Jan 25.
• [25] Urothelial expression of neuropilins and VEGF receptors in control and interstitial cystitis patients.Am J Physiol Renal Physiol. 2008 Dec;295(6):F1613-23. doi: 10.1152/ajprenal.90344.2008. Epub 2008 Sep 24.
• [26] cDNA cloning and characterization of a novel nucleolar protein.Mol Biol Cell. 1996 Jul;7(7):1015-24. doi: 10.1091/mbc.7.7.1015.
• [27] RMP promotes venous metastases of hepatocellular carcinoma through promoting IL-6 transcription.Oncogene. 2015 Mar 19;34(12):1575-83. doi: 10.1038/onc.2014.84. Epub 2014 Apr 7.
• [28] Changes in human bladder epithelial cell gene expression associated with interstitial cystitis or antiproliferative factor treatment.Physiol Genomics. 2003 Jul 7;14(2):107-15. doi: 10.1152/physiolgenomics.00055.2003.
• [29] The role of TSG-6 and uroplakin III in bladder pain syndrome/ interstitial cystitis in rats and humans.Iran J Basic Med Sci. 2017 Nov;20(11):1242-1249. doi: 10.22038/IJBMS.2017.9540.