Details of Disease

Disease Name

Pituitary gland disorder

pituitary gland disorder; pituitary gland disease or disorder; pituitary gland disease; pituitary disease; disorder of pituitary gland; disease or disorder of pituitary gland; disease of pituitary gland

Definition

A disease involving the pituitary gland.

Disease Hierarchy

DISWD40R: Disease

DISRGY2N: Endocrine disease

DIS6ZC3X: Brain disease

DIS7XB48: Pituitary gland disorder

Disease Identifiers

MONDO ID

MONDO_0003381

MESH ID

D010900

UMLS CUI

C0032002

MedGen ID

45934

SNOMED CT ID

399244003

General Information of Disease (ID: DIS7XB48)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 15 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AVPR1B	TTL9MHW	Limited	Altered Expression	[1]
KISS1R	TT3KBZY	Limited	Biomarker	[2]
NR0B1	TTTK36V	Limited	Altered Expression	[3]
AVPR1A	TT4TFGN	Strong	Altered Expression	[1]
FSHB	TT13GFV	Strong	Altered Expression	[4]
GH1	TTT3YKH	Strong	Biomarker	[5]
GHRHR	TTG4R8V	Strong	Altered Expression	[6]
GNRH1	TT0ID4A	Strong	Biomarker	[7]
GNRHR	TT8R70G	Strong	Genetic Variation	[8]
LEPR	TT0HD6V	Strong	Biomarker	[9]
MC2R	TTPWFDX	Strong	Biomarker	[10]
PRKACA	TT5U49F	Strong	Genetic Variation	[11]
RPH3A	TT9L4J8	Strong	Biomarker	[12]
TACR3	TTBPGLU	Strong	Altered Expression	[13]
USP8	TT1J07C	Strong	Biomarker	[14]
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⏷ Show the Full List of 15 DTT(s)

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC20A1	DTMULXV	Strong	Biomarker	[15]
SLC2A11	DTJK135	Strong	Biomarker	[16]
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This Disease Is Related to 31 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AIP	OTDJ3OSV	Limited	Genetic Variation	[17]
GHRH	OT94U6MO	Limited	Biomarker	[18]
LHX3	OTQ5BAJ9	Limited	Biomarker	[19]
LHX4	OTVX3J6S	Limited	Genetic Variation	[20]
SCG2	OTXWUQQL	Limited	Biomarker	[21]
AMY1A	OT6G4B8O	Strong	Biomarker	[22]
APH1A	OT97F1TU	Strong	Altered Expression	[23]
C1QL1	OTNQ0G3E	Strong	Biomarker	[24]
CABLES1	OTMN4XSX	Strong	Biomarker	[25]
CAND1	OTGB6NU0	Strong	Biomarker	[12]
CHGB	OT7SAQT2	Strong	Biomarker	[16]
CIRBP	OTXWTPBL	Strong	Altered Expression	[26]
CSH1	OT33HTRR	Strong	Biomarker	[27]
CSH2	OTW8JVAN	Strong	Biomarker	[27]
CST8	OTT2FRCJ	Strong	Biomarker	[28]
EGR4	OT4R3ECK	Strong	Biomarker	[29]
EIF2S3	OTARRES9	Strong	Biomarker	[30]
GNRH2	OTORRM53	Strong	Biomarker	[7]
HESX1	OT5E2Z4G	Strong	Biomarker	[15]
KLK10	OTD573EL	Strong	Altered Expression	[31]
LHX2	OTK61NP8	Strong	Genetic Variation	[32]
MAGEL2	OTXEL4R7	Strong	Genetic Variation	[33]
NMU	OTW9X7BQ	Strong	Biomarker	[34]
PAQR8	OTGZ8W9F	Strong	Altered Expression	[35]
PLAGL1	OTZAO900	Strong	Altered Expression	[36]
POU1F1	OTXT8A5C	Strong	Biomarker	[15]
PRLH	OTJBP360	Strong	Altered Expression	[37]
SFPQ	OTLCIAPJ	Strong	Altered Expression	[23]
SOX21	OTNT50CC	Strong	Genetic Variation	[38]
SOX3	OT1CRCOB	Strong	Biomarker	[39]
TSHB	OTFDI39D	Strong	Altered Expression	[40]
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⏷ Show the Full List of 31 DOT(s)

References

1	Differential delayed responses of arginine vasotocin and its receptors in septo-hypothalamic brain structures and anterior pituitary that sustain hypothalamic-pituitary-adrenal (HPA) axis functions during acute stress.Gen Comp Endocrinol. 2020 Jan 15;286:113302. doi: 10.1016/j.ygcen.2019.113302. Epub 2019 Oct 14.
2	Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women.Biomed Res Int. 2019 Mar 12;2019:6235680. doi: 10.1155/2019/6235680. eCollection 2019.
3	ACTH-dependent precocious pseudopuberty in an infant with DAX1 gene mutation.Eur J Pediatr. 2009 Jan;168(1):65-9. doi: 10.1007/s00431-008-0710-5. Epub 2008 Apr 15.
4	Influence of three lighting regimes during ten weeks growth phase on laying performance, plasma levels- and tissue specific gene expression- of reproductive hormones in Pengxian yellow pullets.PLoS One. 2017 May 11;12(5):e0177358. doi: 10.1371/journal.pone.0177358. eCollection 2017.
5	Brain Glucose-Sensing Mechanism and Energy Homeostasis.Mol Neurobiol. 2019 Feb;56(2):769-796. doi: 10.1007/s12035-018-1099-4. Epub 2018 May 24.
6	The molecular genetics of growth hormone deficiency.Hum Genet. 1998 Sep;103(3):255-72. doi: 10.1007/s004390050815.
7	A Type IIb, but Not Type IIa, GnRH Receptor Mediates GnRH-Induced Release of Growth Hormone in the Ricefield Eel.Front Endocrinol (Lausanne). 2018 Nov 30;9:721. doi: 10.3389/fendo.2018.00721. eCollection 2018.
8	Similarities and differences in the reproductive phenotypes of women with congenital hypogonadotrophic hypogonadism caused by GNRHR mutations and women with polycystic ovary syndrome.Hum Reprod. 2019 Jan 1;34(1):137-147. doi: 10.1093/humrep/dey339.
9	A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26;392(6674):398-401. doi: 10.1038/32911.
10	Antioxidant Treatment Induces Hyperactivation of the HPA Axis by Upregulating ACTH Receptor in the Adrenal and Downregulating Glucocorticoid Receptors in the Pituitary.Oxid Med Cell Longev. 2017;2017:4156361. doi: 10.1155/2017/4156361. Epub 2017 May 9.
11	Somatic PRKACA Mutations: Association With Transition From Pituitary-Dependent to Adrenal-Dependent Cushing Syndrome.J Clin Endocrinol Metab. 2019 Nov 1;104(11):5651-5657. doi: 10.1210/jc.2018-02209.
12	Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells.Endocr J. 2018 Mar 28;65(3):325-334. doi: 10.1507/endocrj.EJ17-0399. Epub 2018 Jan 23.
13	NK3R Mediates the EGF-Induced SL Secretion and mRNA Expression in Grass Carp Pituitary.Int J Mol Sci. 2018 Dec 26;20(1):91. doi: 10.3390/ijms20010091.
14	Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis.Cancers (Basel). 2019 Sep 4;11(9):1302. doi: 10.3390/cancers11091302.
15	Pituitary Stalk Interruption Syndrome: From Clinical Findings to Pathogenesis.J Neuroendocrinol. 2017 Jan;29(1). doi: 10.1111/jne.12451.
16	Co-expression network analysis of differentially expressed genes associated with metastasis in prolactin pituitary tumors.Mol Med Rep. 2014 Jul;10(1):113-8. doi: 10.3892/mmr.2014.2152. Epub 2014 Apr 15.
17	Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don't forget MEN1 genetic analysis.Eur J Endocrinol. 2013 Mar 15;168(4):533-41. doi: 10.1530/EJE-12-0763. Print 2013 Apr.
18	Ghrelin stimulates growth hormone release from the pituitary via hypothalamic growth hormone-releasing hormone neurons in the cichlid, Oreochromis niloticus.Cell Tissue Res. 2018 Nov;374(2):349-365. doi: 10.1007/s00441-018-2870-6. Epub 2018 Jun 23.
19	Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss.BMC Endocr Disord. 2017 Mar 16;17(1):17. doi: 10.1186/s12902-017-0164-8.
20	Contribution of LHX4 Mutations to Pituitary Deficits in a Cohort of 417 Unrelated Patients.J Clin Endocrinol Metab. 2017 Jan 1;102(1):290-301. doi: 10.1210/jc.2016-3158.
21	Characterization of the EM66 Biomarker in the Pituitary and Plasma of Healthy Subjects With Different Gonadotroph Status and Patients With Gonadotroph Tumor.Front Endocrinol (Lausanne). 2019 Feb 22;10:102. doi: 10.3389/fendo.2019.00102. eCollection 2019.
22	Assessing the Effects of Music Listening on Psychobiological Stress in Daily Life.J Vis Exp. 2017 Feb 2;(120):54920. doi: 10.3791/54920.
23	Pituitary-specific repression of placental members of the human growth hormone gene family. A possible mechanism for locus regulation.J Biol Chem. 1993 Apr 25;268(12):8473-9.
24	Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice.Endocrinology. 1992 Jun;130(6):3378-86. doi: 10.1210/endo.130.6.1597149.
25	The Cables1 Gene in Glucocorticoid Regulation of Pituitary Corticotrope Growth and Cushing Disease.J Clin Endocrinol Metab. 2016 Feb;101(2):513-22. doi: 10.1210/jc.2015-3324. Epub 2015 Dec 22.
26	Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway.Oncotarget. 2016 Feb 23;7(8):9175-87. doi: 10.18632/oncotarget.7037.
27	Regulated expression of chimaeric genes containing the 5'-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells.Nucleic Acids Res. 1987 Feb 11;15(3):1297-309. doi: 10.1093/nar/15.3.1297.
28	CCAAT/enhancer binding protein beta regulates expression of the cystatin-related epididymal spermatogenic (Cres) gene.Biol Reprod. 2001 Nov;65(5):1452-61. doi: 10.1095/biolreprod65.5.1452.
29	EGR4 is a master gene responsible for fertility in cryptorchidism.Sex Dev. 2009;3(5):253-63. doi: 10.1159/000249147. Epub 2009 Oct 14.
30	Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulation.EBioMedicine. 2019 Apr;42:470-480. doi: 10.1016/j.ebiom.2019.03.013. Epub 2019 Mar 14.
31	Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study.Appl Immunohistochem Mol Morphol. 2015 Jul;23(6):433-7. doi: 10.1097/PAI.0000000000000108.
32	Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities.Eur J Endocrinol. 2012 Jul;167(1):85-91. doi: 10.1530/EJE-12-0026. Epub 2012 Apr 24.
33	Mutations in MAGEL2 and L1CAM Are Associated With Congenital Hypopituitarism and Arthrogryposis.J Clin Endocrinol Metab. 2019 Dec 1;104(12):5737-5750. doi: 10.1210/jc.2019-00631.
34	A PEGylated analog of short-length Neuromedin U with potent anorectic and anti-obesity effects.Bioorg Med Chem. 2017 Apr 15;25(8):2307-2312. doi: 10.1016/j.bmc.2017.02.023. Epub 2017 Feb 21.
35	Involvement of Membrane Progestin Receptor Beta (mPR/Paqr8) in Sex Pheromone Progestin-Induced Expression of Luteinizing Hormone in the Pituitary of Male Chinese Black Sleeper (Bostrychus Sinensis).Front Endocrinol (Lausanne). 2018 Jul 18;9:397. doi: 10.3389/fendo.2018.00397. eCollection 2018.
36	ZAC1 target genes and pituitary tumorigenesis.Mol Cell Endocrinol. 2010 Sep 15;326(1-2):60-5. doi: 10.1016/j.mce.2010.01.033. Epub 2010 Feb 1.
37	Does prolactin releasing peptide receptor regulate prolactin-secretion in human pituitary adenomas?.Neurosci Lett. 2000 Sep 22;291(3):159-62. doi: 10.1016/s0304-3940(00)01413-0.
38	Sox21 deletion in mice causes postnatal growth deficiency without physiological disruption of hypothalamic-pituitary endocrine axes.Mol Cell Endocrinol. 2017 Jan 5;439:213-223. doi: 10.1016/j.mce.2016.09.005. Epub 2016 Sep 8.
39	Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes.Genetics. 2017 Jul;206(3):1495-1503. doi: 10.1534/genetics.117.202549. Epub 2017 May 17.
40	Correlation of Pit-1 gene expression and Pit-1 content with proliferation and differentiation in human myeloid leukemic cells.Exp Cell Res. 1998 Nov 25;245(1):132-6. doi: 10.1006/excr.1998.4232.