Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTW8JVAN)

DOT Name Chorionic somatomammotropin hormone 2 (CSH2)
Synonyms Choriomammotropin; Lactogen; Placental lactogen; PL
Gene Name CSH2
Related Disease
Bacteremia ( )
Herpes simplex infection ( )
Prostate cancer ( )
Prostate carcinoma ( )
Atrial fibrillation ( )
Breast cancer ( )
Breast carcinoma ( )
Candidiasis ( )
Carpal tunnel syndrome ( )
Choriocarcinoma ( )
Chromosomal disorder ( )
Cockayne syndrome type 2 ( )
Cowden disease ( )
Craniosynostosis 2 ( )
Dilated cardiomyopathy 1A ( )
Germ cell tumor ( )
Head-neck squamous cell carcinoma ( )
Huntington disease ( )
Lung cancer ( )
Lung carcinoma ( )
Myocardial infarction ( )
Neoplasm ( )
Non-small-cell lung cancer ( )
Pituitary gland disorder ( )
Premature aging syndrome ( )
Seminoma ( )
Skin cancer ( )
Testicular germ cell tumor ( )
Type-1/2 diabetes ( )
UV-sensitive syndrome ( )
Adrenoleukodystrophy ( )
Advanced cancer ( )
Methicillin-resistant staphylococci infection ( )
Cockayne syndrome type 1 ( )
Cytomegalovirus infection ( )
Fetal growth restriction ( )
Intellectual disability ( )
Leukodystrophy ( )
Malaria ( )
Metastatic malignant neoplasm ( )
Myeloproliferative neoplasm ( )
Nephropathy ( )
Nervous system disease ( )
Neuroblastoma ( )
Pituitary tumor ( )
UniProt ID
CSH2_HUMAN
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Pfam ID
PF00103
Sequence
MAAGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAHRAHQLAIDTYQEFEET
YIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELLRISLLLIESWLEPVRFLR
SMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRRTGQILKQTYSKFDTNSHNHD
ALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF
Function Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
KEGG Pathway
Cytokine-cytokine receptor interaction (hsa04060 )
Neuroactive ligand-receptor interaction (hsa04080 )
PI3K-Akt sig.ling pathway (hsa04151 )
JAK-STAT sig.ling pathway (hsa04630 )
Growth hormone synthesis, secretion and action (hsa04935 )

Molecular Interaction Atlas (MIA) of This DOT

45 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Bacteremia DIS6N9RZ Definitive Genetic Variation [1]
Herpes simplex infection DISL1SAV Definitive Altered Expression [2]
Prostate cancer DISF190Y Definitive Genetic Variation [3]
Prostate carcinoma DISMJPLE Definitive Genetic Variation [3]
Atrial fibrillation DIS15W6U Strong Biomarker [4]
Breast cancer DIS7DPX1 Strong Biomarker [5]
Breast carcinoma DIS2UE88 Strong Biomarker [5]
Candidiasis DISIRYMU Strong Biomarker [6]
Carpal tunnel syndrome DISHQ3BE Strong Biomarker [7]
Choriocarcinoma DISDBVNL Strong Posttranslational Modification [8]
Chromosomal disorder DISM5BB5 Strong Biomarker [9]
Cockayne syndrome type 2 DIS3X0GQ Strong Biomarker [10]
Cowden disease DISMYKCE Strong Biomarker [11]
Craniosynostosis 2 DISBJX9D Strong Biomarker [10]
Dilated cardiomyopathy 1A DIS0RK9Z Strong Biomarker [12]
Germ cell tumor DIS62070 Strong Biomarker [13]
Head-neck squamous cell carcinoma DISF7P24 Strong Biomarker [14]
Huntington disease DISQPLA4 Strong Biomarker [15]
Lung cancer DISCM4YA Strong Biomarker [16]
Lung carcinoma DISTR26C Strong Genetic Variation [17]
Myocardial infarction DIS655KI Strong Biomarker [18]
Neoplasm DISZKGEW Strong Biomarker [19]
Non-small-cell lung cancer DIS5Y6R9 Strong Biomarker [20]
Pituitary gland disorder DIS7XB48 Strong Biomarker [21]
Premature aging syndrome DIS51AGT Strong Genetic Variation [22]
Seminoma DIS3J8LJ Strong Biomarker [23]
Skin cancer DISTM18U Strong Biomarker [24]
Testicular germ cell tumor DIS5RN24 Strong Genetic Variation [13]
Type-1/2 diabetes DISIUHAP Strong Biomarker [7]
UV-sensitive syndrome DISHCN4B Strong Genetic Variation [25]
Adrenoleukodystrophy DISTUD1F moderate Biomarker [26]
Advanced cancer DISAT1Z9 moderate Altered Expression [27]
Methicillin-resistant staphylococci infection DIS6DRDZ moderate Biomarker [28]
Cockayne syndrome type 1 DIS9JFVY Limited Biomarker [29]
Cytomegalovirus infection DISCEMGC Limited Biomarker [30]
Fetal growth restriction DIS5WEJ5 Limited Biomarker [30]
Intellectual disability DISMBNXP Limited Biomarker [31]
Leukodystrophy DISVY1TT Limited Genetic Variation [31]
Malaria DISQ9Y50 Limited Genetic Variation [32]
Metastatic malignant neoplasm DIS86UK6 Limited Biomarker [33]
Myeloproliferative neoplasm DIS5KAPA Limited Biomarker [34]
Nephropathy DISXWP4P Limited Biomarker [35]
Nervous system disease DISJ7GGT Limited Genetic Variation [36]
Neuroblastoma DISVZBI4 Limited Biomarker [37]
Pituitary tumor DISN67JD Limited Altered Expression [38]
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⏷ Show the Full List of 45 Disease(s)
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the methylation of Chorionic somatomammotropin hormone 2 (CSH2). [39]
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3 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Irinotecan DMP6SC2 Approved Irinotecan decreases the expression of Chorionic somatomammotropin hormone 2 (CSH2). [40]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Chorionic somatomammotropin hormone 2 (CSH2). [41]
Forskolin DM6ITNG Investigative Forskolin decreases the expression of Chorionic somatomammotropin hormone 2 (CSH2). [42]
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References

1 Potential synergy activity of the novel ceragenin, CSA-13, against carbapenem-resistant Acinetobacter baumannii strains isolated from bacteremia patients.Biomed Res Int. 2014;2014:710273. doi: 10.1155/2014/710273. Epub 2014 Mar 24.
2 Contributions of nucleotide excision repair, DNA polymerase eta, and homologous recombination to replication of UV-irradiated herpes simplex virus type 1.J Biol Chem. 2010 Apr 30;285(18):13761-8. doi: 10.1074/jbc.M110.107920. Epub 2010 Mar 9.
3 Polymorphisms of DNA repair-related genes with susceptibility and prognosis of prostate cancer.Genet Mol Res. 2014 Jan 24;13(2):4419-24. doi: 10.4238/2014.January.24.20.
4 Central Sleep Apnea with Cheyne-Stokes Breathing in Heart Failure - From Research to Clinical Practice and Beyond.Adv Exp Med Biol. 2018;1067:327-351. doi: 10.1007/5584_2018_146.
5 Placental lactogen is expressed but is not translated into protein in breast cancer.PLoS One. 2014 Jan 24;9(1):e87325. doi: 10.1371/journal.pone.0087325. eCollection 2014.
6 Investigation of the in vitro antifungal and antibiofilm activities of ceragenins CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 against Candida species.Diagn Microbiol Infect Dis. 2018 Aug;91(4):324-330. doi: 10.1016/j.diagmicrobio.2018.03.014. Epub 2018 Mar 28.
7 Can ultrasound imaging be used for the diagnosis of carpal tunnel syndrome in diabetic patients? A systemic review and network meta-analysis.J Neurol. 2020 Jul;267(7):1887-1895. doi: 10.1007/s00415-019-09254-8. Epub 2019 Feb 25.
8 Puralpha, a single-stranded deoxyribonucleic acid binding protein, augments placental lactogen gene transcription.Mol Endocrinol. 2004 Feb;18(2):447-57. doi: 10.1210/me.2003-0392. Epub 2003 Nov 26.
9 Genetic variation associated with chromosomal aberration frequency: A genome-wide association study.Environ Mol Mutagen. 2019 Jan;60(1):17-28. doi: 10.1002/em.22236. Epub 2018 Oct 3.
10 Two Novel Heterozygous Mutations in ERCC8 Cause Cockayne Syndrome in a Chinese Patient.Pediatr Neurol. 2015 Sep;53(3):262-5. doi: 10.1016/j.pediatrneurol.2015.06.006. Epub 2015 Jun 14.
11 Mechanistic Interplay between Light Switching and Guest Binding in Photochromic [Pd(2)Dithienylethene(4)] Coordination Cages.J Am Chem Soc. 2019 Feb 6;141(5):2097-2103. doi: 10.1021/jacs.8b11872. Epub 2019 Jan 22.
12 Association between polymorphisms of the HSPB7 gene and Cheyne-Stokes respiration with central sleep apnea in patients with dilated cardiomyopathy and congestive heart failure.Int J Cardiol. 2016 Oct 15;221:926-31. doi: 10.1016/j.ijcard.2016.07.107. Epub 2016 Jul 9.
13 Economy of Standards: European Association of Urology Guideline Changes Influence Treatment Costs in Stage I Testicular Cancer Patients.Urol Int. 2018;100(3):279-287. doi: 10.1159/000486343. Epub 2018 Mar 7.
14 Expression of nucleotide excision repair genes and the risk for squamous cell carcinoma of the head and neck.Cancer. 2002 Jan 15;94(2):393-7. doi: 10.1002/cncr.10231.
15 Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo.Aging (Albany NY). 2011 May;3(5):509-14. doi: 10.18632/aging.100324.
16 The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.Mol Cancer Res. 2015 Sep;13(9):1265-73. doi: 10.1158/1541-7786.MCR-15-0165. Epub 2015 Jun 17.
17 ERCC6/CSB gene polymorphisms and lung cancer risk.Cancer Lett. 2009 Jan 8;273(1):172-6. doi: 10.1016/j.canlet.2008.08.002. Epub 2008 Sep 11.
18 Xin-Ji-Er-Kang Alleviates Myocardial Infarction-Induced Cardiovascular Remodeling in Rats by Inhibiting Endothelial Dysfunction.Biomed Res Int. 2019 Jun 25;2019:4794082. doi: 10.1155/2019/4794082. eCollection 2019.
19 Placental genes and breast cancer: can the offspring's or father's genotypes predict mother's risk?.Epidemiology. 2003 Mar;14(2):251-3. doi: 10.1097/01.EDE.0000050696.19411.C0.
20 Impact of Staging With Positron-emission Tomography (PET) and Comorbidities on Management and Survival of American Veterans With Stage I-III Non-Small Cell Lung Cancer.Am J Clin Oncol. 2018 May;41(5):513-518. doi: 10.1097/COC.0000000000000316.
21 Regulated expression of chimaeric genes containing the 5'-flanking regions of human growth hormone-related genes in transiently transfected rat anterior pituitary tumor cells.Nucleic Acids Res. 1987 Feb 11;15(3):1297-309. doi: 10.1093/nar/15.3.1297.
22 Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth.Cell Cycle. 2014;13(13):2029-37. doi: 10.4161/cc.29018. Epub 2014 Apr 29.
23 The testis-specific expression pattern of the growth hormone/placental lactogen (GH/PL) gene cluster changes with malignancy.Hum Pathol. 1999 Oct;30(10):1201-6. doi: 10.1016/s0046-8177(99)90038-2.
24 Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.Cell. 1997 May 2;89(3):425-35. doi: 10.1016/s0092-8674(00)80223-8.
25 Generation of splice switching oligonucleotides targeting the Cockayne syndrome group B gene product in order to change the diseased cell state.Biochem Biophys Res Commun. 2018 Jun 2;500(2):163-169. doi: 10.1016/j.bbrc.2018.04.015. Epub 2018 Apr 9.
26 Predicted structures of two proteins involved in human diseases.Cell Biochem Biophys. 2001;35(1):35-47. doi: 10.1385/CBB:35:1:35.
27 The CSB repair factor is overexpressed in cancer cells, increases apoptotic resistance, and promotes tumor growth.DNA Repair (Amst). 2013 Apr 1;12(4):293-9. doi: 10.1016/j.dnarep.2013.01.008. Epub 2013 Feb 16.
28 CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model.Clin Orthop Relat Res. 2018 Jun;476(6):1311-1323. doi: 10.1097/01.blo.0000533624.79802.e1.
29 Reduction of sleep-disordered breathing following effective percutaneous mitral valve repair with the MitraClip system.Sleep Breath. 2019 Sep;23(3):815-824. doi: 10.1007/s11325-018-1764-x. Epub 2018 Dec 6.
30 Prospective Cohort Study of Congenital Cytomegalovirus Infection during Pregnancy with Fetal Growth Restriction: Serologic Analysis and Placental Pathology.J Pediatr. 2019 Mar;206:42-48.e2. doi: 10.1016/j.jpeds.2018.10.003. Epub 2018 Nov 6.
31 A possible cranio-oro-facial phenotype in Cockayne syndrome.Orphanet J Rare Dis. 2013 Jan 14;8:9. doi: 10.1186/1750-1172-8-9.
32 Antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A and to the C terminus of merozoite surface protein 1 correlate with reduced placental malaria in Cameroonian women.Infect Immun. 2004 Mar;72(3):1603-7. doi: 10.1128/IAI.72.3.1603-1607.2004.
33 Breast carcinoma in pregnancy with spheroid-like placental metastases-a case report.APMIS. 2018 May;126(5):448-452. doi: 10.1111/apm.12827. Epub 2018 Apr 17.
34 Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders.Br J Haematol. 1996 Jan;92(1):60-6. doi: 10.1046/j.1365-2141.1996.00297.x.
35 Risk factors of cardiac surgery-associated acute kidney injury: development and validation of a perioperative predictive nomogram.J Nephrol. 2019 Dec;32(6):937-945. doi: 10.1007/s40620-019-00624-z. Epub 2019 Jun 26.
36 Multisystem analyses of two Cockayne syndrome associated proteins CSA and CSB reveal shared and unique functions.DNA Repair (Amst). 2019 Nov;83:102696. doi: 10.1016/j.dnarep.2019.102696. Epub 2019 Sep 12.
37 Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12502-12507. doi: 10.1073/pnas.1610198113. Epub 2016 Oct 18.
38 Differential binding of rat pituitary-specific nuclear factors to the 5'-flanking region of pituitary and placental members of the human growth hormone gene family.Mol Cell Biochem. 1991 Aug 14;106(2):181-7. doi: 10.1007/BF00230184.
39 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
40 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
41 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
42 Effects of valproic acid on syncytialization in human placental trophoblast cell lines. Toxicol Appl Pharmacol. 2023 Sep 1;474:116611. doi: 10.1016/j.taap.2023.116611. Epub 2023 Jun 28.