Details of Disease

General Information of Disease (ID: DISJH7UX)

• Disease Name: Tendinopathy
• Synonyms: disorder of tendon; tendon disease or disorder; disease or disorder of tendon; tendon disease; disease of tendon
• Definition: Disorders that are causes by overuse of tendons.
• Disease Hierarchy:
  DISKXBS3: Connective tissue disorder
  DISPPN0O: Musculoskeletal disorder
  DISWD40R: Disease
  DISJH7UX: Tendinopathy
• Disease Identifiers:
  MONDO ID: MONDO_0100010
  UMLS CUI: C0151936
  MedGen ID: 508839
  SNOMED CT ID: 68172002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADAMTS4	TTYG6BU	moderate	Genetic Variation	[1]
MMP8	TTGA1IV	moderate	Genetic Variation	[2]
FGF10	TTNPEFX	Strong	Genetic Variation	[3]
LMO2	TTFX379	Strong	Altered Expression	[4]
PTGIS	TTLXKZR	Strong	Biomarker	[5]
PRNP	TTY5F9C	Definitive	Biomarker	[6]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCB6	DTF9Y2V	Definitive	Biomarker	[6]

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
COL5A1	OT24078H	moderate	Genetic Variation	[7]
ADAMTS3	OT2U6VF5	Strong	Biomarker	[8]
FCRL3	OTIFXFWL	Strong	Genetic Variation	[9]
GDF7	OTNZY74B	Strong	Biomarker	[10]
P3H3	OTRC8QCM	Strong	Biomarker	[11]
RBFOX2	OTXY1WVH	Strong	Biomarker	[12]
SEMA4B	OT1Y3YZD	Strong	Biomarker	[13]
THBS4	OTA1T9KK	Strong	Altered Expression	[14]
TRABD	OTCFGFJH	Strong	Altered Expression	[4]
C4BPA	OTHNH6Y8	Definitive	Biomarker	[6]
CARD14	OTADQHOV	Definitive	Biomarker	[6]
PRDX2	OTLWCY9T	Definitive	Biomarker	[6]

References

• [1] Promoter methylation status of the TIMP2 and ADAMTS4 genes and patellar tendinopathy.J Sci Med Sport. 2018 Apr;21(4):378-382. doi: 10.1016/j.jsams.2017.08.016. Epub 2017 Sep 1.
• [2] Matrix metalloproteinase-1 (MMP-1) and (MMP-8) gene polymorphisms promote increase and remodeling of the collagen III and V in posterior tibial tendinopathy.Histol Histopathol. 2018 Sep;33(9):929-936. doi: 10.14670/HH-11-982. Epub 2018 Mar 13.
• [3] BMP4 and FGF3 haplotypes increase the risk of tendinopathy in volleyball athletes.J Sci Med Sport. 2015 Mar;18(2):150-5. doi: 10.1016/j.jsams.2014.02.011. Epub 2014 Mar 1.
• [4] Gene expression analysis in calcific tendinopathy of the rotator cuff.Eur Cell Mater. 2011 Jun 20;21:548-57. doi: 10.22203/ecm.v021a41.
• [5] Divergent roles of prostacyclin and PGE(2) in human tendinopathy.Arthritis Res Ther. 2019 Mar 13;21(1):74. doi: 10.1186/s13075-019-1855-5.
• [6] Intratendon delivery of leukocyte-rich platelet-rich plasma at early stage promotes tendon repair in a rabbit Achilles tendinopathy model.J Tissue Eng Regen Med. 2020 Mar;14(3):452-463. doi: 10.1002/term.3006. Epub 2019 Dec 23.
• [7] Variants within the MMP3 gene are associated with Achilles tendinopathy: possible interaction with the COL5A1 gene.Br J Sports Med. 2009 Jul;43(7):514-20. doi: 10.1136/bjsm.2008.053892. Epub 2008 Nov 28.
• [8] The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.Matrix Biol. 2008 Jun;27(5):393-401. doi: 10.1016/j.matbio.2008.02.002. Epub 2008 Apr 2.
• [9] Fc receptor-like 3 (-169T>C) polymorphism increases the risk of tendinopathy in volleyball athletes: a case control study.BMC Med Genet. 2018 Jul 18;19(1):119. doi: 10.1186/s12881-018-0633-6.
• [10] Aspirin promotes tenogenic differentiation of tendon stem cells and facilitates tendinopathy healing through regulating the GDF7/Smad1/5 signaling pathway.J Cell Physiol. 2020 May;235(5):4778-4789. doi: 10.1002/jcp.29355. Epub 2019 Oct 21.
• [11] Genome-wide analysis identifies differential promoter methylation of Leprel2, Foxf1, Mmp25, Igfbp6, and Peg12 in murine tendinopathy.J Orthop Res. 2017 May;35(5):947-955. doi: 10.1002/jor.23393. Epub 2016 Aug 29.
• [12] Alternative splicing induces cytoplasmic localization of RBFOX2 protein in calcific tendinopathy.Exp Mol Pathol. 2019 Aug;109:36-41. doi: 10.1016/j.yexmp.2019.104264. Epub 2019 May 23.
• [13] Metal artifact reduction MRI of total ankle arthroplasty implants.Eur Radiol. 2018 May;28(5):2216-2227. doi: 10.1007/s00330-017-5153-9. Epub 2017 Dec 7.
• [14] MicroRNA 148a-3p promotes Thrombospondin-4 expression and enhances angiogenesis during tendinopathy development by inhibiting Krppel-like factor 6.Biochem Biophys Res Commun. 2018 Jul 12;502(2):276-282. doi: 10.1016/j.bbrc.2018.05.167. Epub 2018 May 26.