Details of Disease

General Information of Disease (ID: DISJW6E6)

• Disease Name: Edema
• Synonyms: myxedema
• Disease Class: MG29: Oedema
• Definition: A condition characterized by severe hypothyroidism that is caused by autoimmune thyroid gland disorders, surgical reduction of thyroid tissue, radiation exposure, and viral infections. Signs and symptoms include generalized fatigue, lethargy, increased body weight, pale, edematous and thickened skin, low blood pressure, constipation and cold intolerance.|Editor note: myxedema can also refer to a dermatological change that can occur in hypothyroidism and some forms of hyperthyroidism.
• Disease Hierarchy:
  DISR0H6D: Hypothyroidism
  DISJW6E6: Edema
• ICD Code:
  ICD-11: ICD-11: MG29
  ICD-10: ICD-10: R60
• Disease Identifiers:
  MONDO ID: MONDO_0009718
  MESH ID: D009230
  UMLS CUI: C0027145
  OMIM ID: 255900
  MedGen ID: 6506
  HPO ID: HP:0000969
  SNOMED CT ID: 43153006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 22 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetazolamide	DM1AF5U	Approved	Small molecular drug	[1]
Amiloride	DMRTSGP	Approved	Small molecular drug	[2]
Azosemide	DMD6TOU	Approved	Small molecular drug	[3]
Bumetanide	DMRV7H0	Approved	Small molecular drug	[4]
Chlorothiazide	DMLHESP	Approved	Small molecular drug	[5]
Chlorthalidone	DM4DMBT	Approved	Small molecular drug	[6]
Clopamide	DMUWX51	Approved	Small molecular drug	[3]
Ethacrynic	DM4I1TN	Approved	NA	[7]
Ethacrynic acid	DM60QMR	Approved	Small molecular drug	[8]
Furosemide	DMMQ8ZG	Approved	Small molecular drug	[9]
Hydrochlorothiazide	DMUSZHD	Approved	Small molecular drug	[10]
Hydroflumethiazide	DMVPUQI	Approved	Small molecular drug	[11]
Indapamide	DMGN1PW	Approved	Small molecular drug	[12]
Levothyroxine	DMHN027	Approved	Small molecular drug	[13]
Liothyronine	DM6IR3P	Approved	Small molecular drug	[14]
Mannitol	DMSCDY9	Approved	Small molecular drug	[15]
Methyclothiazide	DMN7SDE	Approved	Small molecular drug	[16]
Metolazone	DMB39LO	Approved	Small molecular drug	[17]
Polythiazide	DMCH80F	Approved	Small molecular drug	[18]
Spironolactone	DM2AQ5N	Approved	Small molecular drug	[19]
Torasemide	DMXKJ6C	Approved	Small molecular drug	[20]
Triamterene	DM2HU9I	Approved	Small molecular drug	[21]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AKB-9788	DMYRV8Q	Investigative	NA	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TSHR	TT6NYJA	Strong	Biomarker	[22]

References

• [1] Acetazolamide FDA Label
• [2] Amiloride FDA Label
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] Bumetanide FDA Label
• [5] Chlorothiazide FDA Label
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7147).
• [7] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [8] Ethacrynic acid FDA Label
• [9] Furosemide FDA Label
• [10] Hydrochlorothiazide FDA Label
• [11] Hydroflumethiazide FDA Label
• [12] Indapamide FDA Label
• [13] Levothyroxine FDA Label
• [14] Liothyronine FDA Label
• [15] Mannitol FDA Label
• [16] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7235).
• [17] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4838).
• [18] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7274).
• [19] Spironolactone FDA Label
• [20] Comparative effects of furosemide and other diuretics in the treatment of heart failure: a systematic review and combined meta-analysis of randomized controlled trials. Heart Fail Rev. 2021 Jan;26(1):127-136.
• [21] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4329).
• [22] Preparation and characterization of monoclonal antithyrotropin receptor antibodies obtained from peripheral lymphocytes of hypothyroid patients with primary myxedema.J Clin Endocrinol Metab. 1994 Dec;79(6):1600-4. doi: 10.1210/jcem.79.6.7989462.