General Information of Disease (ID: DISR0H6D)

Disease Name Hypothyroidism
Synonyms hypothyroid; thyroid deficiency; thyroid insufficiency; hypothyroidism; underactive thyroid
Disease Class 5A00: Hypo-thyroidism
Definition Abnormally low levels of thyroid hormone.
Disease Hierarchy
DIS5T3X5: Thyroid disease
DISR0H6D: Hypothyroidism
ICD Code
ICD-11
ICD-11: 5A00
ICD-10
ICD-10: E03.8, E03.9
ICD-9
ICD-9: 244
Expand ICD-11
'5A00
Expand ICD-10
'E03.8; 'E03.9
Expand ICD-9
244
Disease Identifiers
MONDO ID
MONDO_0005420
MESH ID
D007037
UMLS CUI
C0020676
MedGen ID
6991
HPO ID
HP:0000821
SNOMED CT ID
40930008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 4 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Levothyroxine DMHN027 Approved Small molecular drug [1]
Liothyronine DM6IR3P Approved Small molecular drug [2]
Thyroglobulin DMZ6OAV Approved NA [2]
Thyrotropin DMJ47QC Approved NA [2]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BCT303 DMUFY4K Phase 2 NA [3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 106 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADA TTLP57V Limited Altered Expression [4]
APOE TTKS9CB Limited Genetic Variation [5]
ATP4A TTF1QVM Limited Genetic Variation [6]
FOXP3 TT1X3QF Limited Biomarker [7]
FSHR TTZFDBT Limited Biomarker [8]
NRG1 TTEH395 Limited Genetic Variation [9]
PTH1R TTFPD47 Limited Genetic Variation [6]
RET TT4DXQT Limited Genetic Variation [10]
SLC5A5 TTW7HI9 Limited Genetic Variation [11]
STAT1 TTN7R6K Limited Genetic Variation [12]
THRB TTGER3L Limited Biomarker [13]
TIGIT TTWNL74 Limited Altered Expression [14]
TRH TT2Z39D Limited Altered Expression [15]
IGF1 TTT6LOU moderate Altered Expression [16]
SLC26A4 TT7X02I moderate Genetic Variation [17]
ABCB11 TTUXCAF Strong Biomarker [18]
ACHE TT1RS9F Strong Biomarker [19]
ADRB2 TTG8ZWP Strong Altered Expression [20]
ALAD TTJHKYD Strong Altered Expression [21]
ANGPTL3 TT59GO7 Strong Altered Expression [22]
ANTXR2 TTOD34I Strong Altered Expression [23]
ANXA1 TTUCK4B Strong Biomarker [24]
ANXA2 TT4YANI Strong Biomarker [24]
ANXA5 TT2Z83I Strong Biomarker [24]
APOC3 TTXOZQ1 Strong Biomarker [25]
AQP3 TTLDNMQ Strong Biomarker [26]
ARSA TTYQANR Strong Biomarker [27]
ATP2A2 TTE6THL Strong Biomarker [28]
ATP7B TTOPO51 Strong Genetic Variation [29]
BDNF TTSMLOH Strong Biomarker [30]
CAV1 TTXUBN2 Strong Biomarker [31]
CBLB TTHRAIJ Strong Genetic Variation [32]
CD2 TTJDUNO Strong Genetic Variation [32]
CD80 TT89Z17 Strong Genetic Variation [32]
CDK5R1 TTBYM6V Strong Biomarker [33]
CETP TTFQAYR Strong Altered Expression [34]
COASY TT4YO0Z Strong Genetic Variation [35]
COL1A2 TTUABC1 Strong Biomarker [36]
CYP19A1 TTSZLWK Strong Altered Expression [37]
DIO1 TTU3X26 Strong Genetic Variation [38]
DPYSL2 TTZCW3T Strong Biomarker [39]
ENTPD1 TTYM8DJ Strong Biomarker [40]
F7 TTF0EGX Strong Biomarker [41]
FADS2 TTT2VDU Strong Genetic Variation [32]
FLT3 TTGJCWZ Strong Genetic Variation [32]
FMNL1 TTW20PQ Strong Genetic Variation [42]
FYN TT2B9KF Strong Genetic Variation [32]
GH1 TTT3YKH Strong Biomarker [43]
GHRHR TTG4R8V Strong Genetic Variation [44]
GIP TT40HS5 Strong Biomarker [45]
GPX1 TTYAHBP Strong Therapeutic [46]
GRK3 TT5A4DX Strong Biomarker [47]
GSN TTUH7OM Strong Biomarker [48]
HCN2 TT9EUT4 Strong Altered Expression [49]
IGFBP2 TTU4QSN Strong Biomarker [50]
IL12RB2 TT4SWR8 Strong Genetic Variation [32]
IL2RA TT10Y9E Strong Genetic Variation [32]
INSR TTCBFJO Strong Genetic Variation [32]
ITK TT3C80U Strong Genetic Variation [32]
JAK1 TT6DM01 Strong Genetic Variation [32]
KAT6B TTH4VJL Strong CausalMutation [51]
KCNQ1 TT846HF Strong Biomarker [52]
KDM5C TT94UCF Strong Biomarker [53]
KEAP1 TT3Z6Y9 Strong Genetic Variation [32]
KRT17 TTKV0EC Strong Altered Expression [54]
KRT6A TT2FX8W Strong Altered Expression [54]
KSR1 TTHL1TV Strong Genetic Variation [55]
KYNU TTWQM3J Strong CausalMutation [56]
L1CAM TTC9D3K Strong Biomarker [57]
LDLR TTH0DUS Strong Altered Expression [58]
METAP2 TTZL0OI Strong Biomarker [59]
MSTN TTM8I2X Strong Biomarker [60]
MTTP TTUS1RD Strong Genetic Variation [61]
MYH7 TTNIMDP Strong Biomarker [62]
NCAM1 TTVXPHT Strong Biomarker [63]
NEK6 TT8I2M7 Strong Genetic Variation [32]
NFKB1 TTUIZKC Strong Genetic Variation [32]
NGF TTDN3LF Strong Biomarker [64]
NR1D1 TTAD1O8 Strong Altered Expression [65]
PAM TTF4ZPC Strong Biomarker [66]
PCNA TTLG1PD Strong Altered Expression [67]
PCSK1 TTED9LZ Strong Biomarker [68]
PDE10A TTJW4LU Strong Genetic Variation [32]
PDE3B TTN34SQ Strong Altered Expression [69]
PLA2G2A TTO8QRU Strong Biomarker [70]
PLIN1 TTIV27N Strong Altered Expression [37]
PLOD1 TTEKJP3 Strong Biomarker [71]
PLOD2 TT8MEUD Strong Biomarker [71]
PNPLA3 TTEUAEH Strong Altered Expression [72]
PRL TTJ2TSA Strong Biomarker [73]
SH2B3 TT36N7Z Strong Genetic Variation [32]
SHH TTIENCJ Strong Biomarker [74]
SLC2A1 TT79TKF Strong Biomarker [75]
SLC2A12 TTZO36H Strong Altered Expression [67]
SLC9A1 TTGSEFH Strong Biomarker [76]
SLCO1C1 TT340CE Strong Biomarker [77]
SRD5A1 TTTU72V Strong Biomarker [78]
STAR TTEI40H Strong Biomarker [79]
TNFRSF11B TT2CJ75 Strong Genetic Variation [32]
TNFRSF14 TTWGTC1 Strong Genetic Variation [32]
TNFRSF1B TT63WSF Strong Genetic Variation [32]
TRB TT84HCW Strong Genetic Variation [80]
TRHR TT4J8MF Strong Altered Expression [81]
TYK2 TTBYWP2 Strong Genetic Variation [32]
UCP2 TTSC2YM Strong Altered Expression [82]
UCP3 TT12RJK Strong Altered Expression [83]
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⏷ Show the Full List of 106 DTT(s)
This Disease Is Related to 11 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC16A2 DTQ8MP1 Limited Biomarker [77]
SLC20A1 DTMULXV Limited Genetic Variation [84]
SLC30A10 DTYBI73 Limited Biomarker [85]
KCNH7 DT3WXPI Strong Genetic Variation [32]
SLC13A1 DTIZEMV Strong Altered Expression [86]
SLC16A10 DTPAQJO Strong Biomarker [87]
SLC25A37 DTLBGTZ Strong Genetic Variation [32]
SLC26A5 DTPGHJ7 Strong Biomarker [88]
SLC2A8 DT2I7BM Strong Altered Expression [67]
SLC34A1 DT42EWA Strong Biomarker [89]
SLC39A14 DTZ6IJW Strong Biomarker [85]
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⏷ Show the Full List of 11 DTP(s)
This Disease Is Related to 5 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
BAAT DERA3OF Strong Biomarker [90]
DIO3 DET89OV Strong Genetic Variation [91]
GPT DER5HFI Strong Biomarker [92]
GSTO2 DEHMPZR Strong Biomarker [93]
HSD3B1 DERDQWN Strong Biomarker [79]
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This Disease Is Related to 144 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CDH13 OTD2CYM5 Limited Genetic Variation [9]
CHD7 OTHNIZWZ Limited Genetic Variation [94]
CLDN11 OTNN6UTL Limited Biomarker [95]
COX2 OTTMVBJJ Limited Biomarker [96]
GLIS3 OTBC960E Limited Biomarker [97]
HESX1 OT5E2Z4G Limited Biomarker [44]
LHX4 OTVX3J6S Limited Genetic Variation [44]
MPZL2 OTKFNDUI Limited Biomarker [98]
POU1F1 OTXT8A5C Limited Genetic Variation [84]
SCGB3A2 OTB63PHR Limited Biomarker [99]
TRPC4AP OTNJ9IFS Limited Autosomal dominant [100]
PAX8 OTRPD9MI moderate Biomarker [101]
TG OT3ELHIJ moderate Genetic Variation [102]
TSHB OTFDI39D moderate Biomarker [103]
ACAP1 OTPFQ2QC Strong Genetic Variation [32]
ADCY7 OTAWMGP3 Strong Genetic Variation [32]
AGO2 OT4JY32Q Strong Genetic Variation [32]
AMN OTS1TJXG Strong Biomarker [104]
ANGPTL8 OTQFINCD Strong Biomarker [22]
APOA5 OTEVKLVA Strong Biomarker [105]
APOBR OT9EUZX3 Strong Biomarker [106]
ARID5B OTUQ4CQY Strong Genetic Variation [32]
ATP5PO OTU3MCTN Strong Therapeutic [107]
ATP8B1 OTALGS63 Strong Genetic Variation [18]
BACH2 OT17GS18 Strong Genetic Variation [32]
BAD OT63ERYM Strong Biomarker [108]
BHLHE40 OTITX14U Strong Genetic Variation [32]
C1QTNF6 OT57EPQC Strong Genetic Variation [32]
CAMK4 OT47RDGV Strong Genetic Variation [32]
CAPZB OTF1A4N0 Strong Genetic Variation [109]
CCN4 OT69BER9 Strong Genetic Variation [32]
CD226 OT4UG0KB Strong Genetic Variation [32]
CD247 OT45FGUX Strong Genetic Variation [32]
CNBP OTTGM9NK Strong Biomarker [110]
COL2A1 OT5E59C8 Strong Therapeutic [111]
COQ9 OTM2T1FI Strong Biomarker [112]
CP OTM8JE4Y Strong Biomarker [29]
CPT1C OT8F1MBF Strong Genetic Variation [32]
DACT2 OTNLCC0K Strong Biomarker [113]
DCX OTISR7K3 Strong Biomarker [96]
DIO2 OTGPNSLH Strong Biomarker [114]
DMP1 OTBWBWW7 Strong Genetic Variation [115]
DNAJC17 OTXRONMF Strong Biomarker [116]
DNAJC3 OT7ROIJF Strong Genetic Variation [117]
DNASE2 OT6RC1BL Strong Altered Expression [118]
DUOX2 OTU14HCN Strong Genetic Variation [119]
DUOXA2 OT7AZBZJ Strong Genetic Variation [120]
EDARADD OT0G52MC Strong Genetic Variation [32]
EFNA5 OTOH4DRR Strong Altered Expression [121]
ELAVL4 OT3YH6J6 Strong Biomarker [122]
ELMO1 OTY2ORXK Strong Genetic Variation [32]
FGD2 OTQBDP2E Strong Genetic Variation [32]
FMR1 OTWEV0T5 Strong Genetic Variation [123]
FOXE1 OT5IR5IT Strong Genetic Variation [124]
FOXK1 OTLZGS7J Strong Genetic Variation [32]
GNAS OTMH8BKJ Strong Genetic Variation [125]
GSTT2B OTCMRDLE Strong Genetic Variation [126]
HIPK1 OTSEA8RS Strong Genetic Variation [32]
HORMAD2 OTL2ENWI Strong Genetic Variation [32]
IFIH1 OTZA2AHA Strong Genetic Variation [127]
IGSF1 OT3XD6U2 Strong Biomarker [128]
INPP5B OT0SC8W5 Strong Genetic Variation [32]
IP6K3 OTKUIVQZ Strong Genetic Variation [32]
IQCN OTFV1MTW Strong Genetic Variation [32]
IRF4 OT1DHQ1P Strong Genetic Variation [32]
IRF5 OT8SIIAP Strong Genetic Variation [32]
IYD OT8BQWTE Strong Biomarker [129]
KCNE2 OTUO214Y Strong Biomarker [52]
KCTD19 OTEBGKAF Strong Genetic Variation [32]
LHX3 OTQ5BAJ9 Strong Genetic Variation [130]
LIPC OTZY5SC9 Strong Biomarker [131]
LPP OT6TU8SE Strong Genetic Variation [32]
LRRC8A OT23OE7H Strong Genetic Variation [32]
MACIR OTPSW8Y8 Strong Genetic Variation [32]
MAGI3 OTDJ5QUH Strong Genetic Variation [132]
MAP1A OTHO8K43 Strong Biomarker [133]
MAP1B OTVXW089 Strong Biomarker [133]
MAP2 OT6UYT3X Strong Biomarker [59]
MB21D2 OT5C4VVU Strong Genetic Variation [32]
MED12 OTQZ4D2X Strong Genetic Variation [134]
MED13 OTP5LEJE Strong Altered Expression [135]
MED7 OTGF64SM Strong Genetic Variation [32]
MICOS10 OTB6D21A Strong Genetic Variation [32]
MLXIPL OTR9MLLW Strong Biomarker [118]
MT1B OTUA4FFH Strong Biomarker [136]
MT3 OTVCZ7HI Strong Biomarker [137]
MYH15 OTWZA8IF Strong Genetic Variation [32]
MYH6 OT3YNCH1 Strong Biomarker [62]
NAA25 OTS3QVF1 Strong Genetic Variation [32]
NCOA1 OTLIUJQD Strong Biomarker [138]
NCOA2 OTMQFPBB Strong Altered Expression [139]
NCOR1 OT04XNOU Strong Biomarker [140]
NCOR2 OTY917X0 Strong Altered Expression [139]
ND3 OT1OC3K3 Strong Biomarker [141]
NEFH OTMSCW5I Strong Therapeutic [142]
NEFL OTQESJV4 Strong Therapeutic [142]
NEFM OT8VCBNF Strong Therapeutic [142]
NFATC1 OT4TMERS Strong Genetic Variation [32]
NKX2-1 OTCMEJTA Strong Biomarker [143]
NRGN OTVGE10W Strong Biomarker [144]
NUDT10 OT61XMYC Strong Biomarker [145]
OTOF OTXQMJY8 Strong Biomarker [146]
PANX1 OTXPEDOK Strong Genetic Variation [32]
PDE8B OT4217NK Strong Genetic Variation [32]
PHKA1 OTLPQCRF Strong Biomarker [147]
PHRF1 OT21KEGX Strong Genetic Variation [32]
PIK3C3 OTLUM9L7 Strong Biomarker [148]
PIK3R5 OT4LNXJU Strong Genetic Variation [32]
PITX2 OTWMXAOY Strong Biomarker [149]
PLEKHA1 OT66PF24 Strong Genetic Variation [32]
PLOD3 OTT00T7Q Strong Biomarker [71]
PLXNC1 OTJ5XKYY Strong Genetic Variation [32]
PNPT1 OTBR2Q0F Strong Genetic Variation [32]
POLG OTDUCT04 Strong Genetic Variation [150]
PPIG OTZ8BTTM Strong Altered Expression [151]
PROP1 OT8GF6N8 Strong Genetic Variation [152]
PTPN22 OTDCNTC3 Strong Genetic Variation [32]
RAB20 OTP9OOVS Strong Genetic Variation [32]
RAB40B OTCA9ZF5 Strong Altered Expression [153]
RAB5B OT06PN42 Strong Genetic Variation [32]
RAB5C OTQE5QQ2 Strong Genetic Variation [32]
RAD51B OTCJVRMY Strong Genetic Variation [32]
RASGRP1 OTX9WN2E Strong Genetic Variation [32]
RELN OTLKMW1O Strong Biomarker [154]
RSBN1L OTKKVOZF Strong Genetic Variation [32]
SBF1 OTW6I9RV Strong Genetic Variation [32]
SERPINA7 OTUYVTSU Strong Altered Expression [155]
SH2D2A OTQSKW7U Strong Genetic Variation [32]
SHBG OTPWU5IW Strong Biomarker [156]
SLC66A1 OTUM63MK Strong Genetic Variation [32]
SPATA13 OTQ8NPAW Strong Genetic Variation [32]
STAT4 OTAK3VFR Strong Genetic Variation [32]
STK25 OT4YPNTF Strong Genetic Variation [32]
TANGO2 OTT9UI89 Strong CausalMutation [157]
TANK OTZSGFIK Strong Genetic Variation [32]
TEF OTY3LAD9 Strong Altered Expression [65]
TIMMDC1 OTIK4I5R Strong Genetic Variation [32]
TMEM131 OT72FBLT Strong Genetic Variation [32]
TOMM70 OT8QBYZ0 Strong Biomarker [158]
TRAM1 OT3I0H8E Strong Biomarker [139]
TRANK1 OT7DH5H4 Strong Genetic Variation [32]
TSBP1 OT5GE8IO Strong Genetic Variation [159]
TTF1 OT4K90WD Strong Biomarker [143]
C2 OTHMF4YM Definitive Biomarker [160]
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⏷ Show the Full List of 144 DOT(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4627).
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037654)
4 Hypothyroidism and hyperthyroidism change ectoenzyme activity in rat platelets.J Cell Biochem. 2018 Jul;119(7):6249-6257. doi: 10.1002/jcb.26856. Epub 2018 Apr 16.
5 Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome.Am J Med Genet A. 2003 Jul 15;120A(2):191-8. doi: 10.1002/ajmg.a.20099.
6 A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.Gastric Cancer. 2017 Nov;20(6):998-1003. doi: 10.1007/s10120-017-0723-8. Epub 2017 May 4.
7 Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats.Exp Ther Med. 2018 Jul;16(1):310-320. doi: 10.3892/etm.2018.6190. Epub 2018 May 18.
8 Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.PLoS One. 2013 Sep 13;8(9):e75478. doi: 10.1371/journal.pone.0075478. eCollection 2013.
9 Detection and interpretation of shared genetic influences on 42 human traits.Nat Genet. 2016 Jul;48(7):709-17. doi: 10.1038/ng.3570. Epub 2016 May 16.
10 A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure.J Clin Endocrinol Metab. 2004 Oct;89(10):4810-6. doi: 10.1210/jc.2004-0365.
11 Exposure to Perchlorate in Lactating Women and Its Associations With Newborn Thyroid Stimulating Hormone.Front Endocrinol (Lausanne). 2018 Jul 3;9:348. doi: 10.3389/fendo.2018.00348. eCollection 2018.
12 Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism.J Clin Immunol. 2012 Dec;32(6):1213-20. doi: 10.1007/s10875-012-9744-6. Epub 2012 Jul 31.
13 Gene expression of T3-regulated genes in a mouse model of the human thyroid hormone resistance.Life Sci. 2017 Feb 1;170:93-99. doi: 10.1016/j.lfs.2016.11.032. Epub 2016 Dec 2.
14 Expression of TIGIT and FCRL3 is Altered in T Cells from Patients with Distinct Patterns of Chronic Autoimmune Thyroiditis.Exp Clin Endocrinol Diabetes. 2019 May;127(5):281-288. doi: 10.1055/a-0597-8948. Epub 2018 Jun 11.
15 Differential effects of hypo- and hyperthyroidism on remodeling of contacts between neurons expressing the neuropeptide EI and tyrosine hydroxylase in hypothalamic areas of the male rat.Peptides. 2019 Mar;113:1-10. doi: 10.1016/j.peptides.2018.12.008. Epub 2018 Dec 24.
16 Prevalence and Course of Endocrinopathy in POEMS Syndrome.J Clin Endocrinol Metab. 2019 Jun 1;104(6):2140-2146. doi: 10.1210/jc.2018-01516.
17 Homology of pendrin, sodium-iodide symporter and apical iodide transporter.Front Biosci (Landmark Ed). 2018 Jun 1;23(10):1864-1873. doi: 10.2741/4677.
18 Hypothyroidism Associated with ATP8B1 Deficiency.J Pediatr. 2015 Dec;167(6):1334-9.e1. doi: 10.1016/j.jpeds.2015.08.037. Epub 2015 Sep 15.
19 Hypothyroidism Enhanced Ectonucleotidases and Acetylcholinesterase Activities in Rat Synaptosomes can be Prevented by the Naturally Occurring Polyphenol Quercetin.Cell Mol Neurobiol. 2017 Jan;37(1):53-63. doi: 10.1007/s10571-016-0342-7. Epub 2016 Feb 16.
20 Increased beta(2)-adrenergic receptor activity by thyroid hormone possibly leads to differentiation and maturation of astrocytes in culture.Cell Mol Neurobiol. 2007 Dec;27(8):1007-21. doi: 10.1007/s10571-007-9202-9. Epub 2007 Sep 8.
21 Delta-aminolevulinate dehydratase (delta-ALA-D) activity in diabetes and hypothyroidism.Clin Biochem. 2007 Mar;40(5-6):321-5. doi: 10.1016/j.clinbiochem.2006.11.016. Epub 2007 Jan 5.
22 Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism.Biomed Res Int. 2019 Jul 17;2019:3814687. doi: 10.1155/2019/3814687. eCollection 2019.
23 The correlation between the incidence of adverse events and progression-free survival in patients treated with cabozantinib for metastatic renal cell carcinoma (mRCC).Med Oncol. 2019 Jan 21;36(2):19. doi: 10.1007/s12032-018-1239-8.
24 In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil.Eur J Biochem. 1996 Dec 15;242(3):506-11. doi: 10.1111/j.1432-1033.1996.0506r.x.
25 Role of thyroid hormone in the expression of apolipoprotein A-IV and C-III genes in rat liver.J Lipid Res. 1993 Feb;34(2):249-59.
26 Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins.J Am Soc Nephrol. 2003 Mar;14(3):566-74. doi: 10.1097/01.asn.0000053417.33945.63.
27 Hypothyroidism in the adult rat causes brain region-specific biochemical dysfunction.J Endocrinol. 1993 Aug;138(2):299-305. doi: 10.1677/joe.0.1380299.
28 SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.Biomed Res Int. 2015;2015:251598. doi: 10.1155/2015/251598. Epub 2015 May 3.
29 Low serum alkaline phosphatase activity due to asymptomatic hypophosphatasia in a teenage girl.Clin Biochem. 2018 Sep;59:90-92. doi: 10.1016/j.clinbiochem.2018.06.018. Epub 2018 Jun 27.
30 The effects of vitamin E on brain derived neurotrophic factor, tissues oxidative damage and learning and memory of juvenile hypothyroid rats.Metab Brain Dis. 2018 Jun;33(3):713-724. doi: 10.1007/s11011-017-0176-0. Epub 2017 Dec 30.
31 Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum.Biol Trace Elem Res. 2011 Dec;144(1-3):1039-49. doi: 10.1007/s12011-011-9089-7. Epub 2011 May 25.
32 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.Am J Hum Genet. 2019 Jan 3;104(1):65-75. doi: 10.1016/j.ajhg.2018.11.008. Epub 2018 Dec 27.
33 Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus.Environ Toxicol. 2014 Aug;29(8):847-55. doi: 10.1002/tox.21811. Epub 2012 Sep 15.
34 Thyroid hormone increases plasma cholesteryl ester transfer protein activity and plasma high-density lipoprotein removal rate in transgenic mice.Metabolism. 2001 May;50(5):530-6. doi: 10.1053/meta.2001.22514.
35 Diagnosis and management of congenital hypothyroidism associated with pseudohypoparathyroidism.Horm Res Paediatr. 2015;83(2):111-7. doi: 10.1159/000369492. Epub 2015 Jan 9.
36 Upregulation of collagen type I gene expression in the ventricular myocardium of thyroidectomized male and female rats.J Mol Cell Cardiol. 1996 Jan;28(1):33-42. doi: 10.1006/jmcc.1996.0004.
37 Hypothyroidism affects lipid and glycogen content and peroxisome proliferator-activated receptor expression in the ovary of the rabbit.Reprod Fertil Dev. 2018 Oct;30(10):1380-1387. doi: 10.1071/RD17502.
38 The relationship of 19 functional polymorphisms in iodothyronine deiodinase and psychological well-being in hypothyroid patients.Endocrine. 2017 Jul;57(1):115-124. doi: 10.1007/s12020-017-1307-4. Epub 2017 May 2.
39 Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus.Mol Cell Endocrinol. 2001 Nov 26;184(1-2):143-50. doi: 10.1016/s0303-7207(01)00592-5.
40 Hypo-and hyperthyroidism affect the ATP, ADP and AMP hydrolysis in rat hippocampal and cortical slices.Neurosci Res. 2005 May;52(1):61-8. doi: 10.1016/j.neures.2005.01.009.
41 The influence of the thyroid function on the metabolic rate of prothrombin, factor VII, and factor X in the rat.Thromb Haemost. 1976 Jun 30;35(3):607-19.
42 Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.Nat Commun. 2018 Oct 26;9(1):4455. doi: 10.1038/s41467-018-06356-1.
43 Combined Growth Hormone and Thyroid-Stimulating Hormone Deficiency in a Japanese Patient with a Novel Frameshift Mutation in IGSF1.Horm Res Paediatr. 2015;84(5):349-54. doi: 10.1159/000438672. Epub 2015 Aug 19.
44 DNA testing in patients with GH deficiency at the time of transition.Growth Horm IGF Res. 2003 Aug;13 Suppl A:S122-9. doi: 10.1016/s1096-6374(03)00068-6.
45 Regulation of thyroid hormones in the secretion of insulin and gastric inhibitory polypeptide in male rats.Metabolism. 1997 Feb;46(2):154-8. doi: 10.1016/s0026-0495(97)90294-8.
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