Details of Disease

General Information of Disease (ID: DISK4TGU)

Disease Name	Headache
Synonyms	chronic daily headaches; intractable headache; cephalgia syndrome; headache, intractable; headaches, chronic; headache, chronic; daily headache, chronic; chronic headaches; headache syndrome; headaches, intractable; headaches, chronic daily; intractable headaches; headache, chronic daily; cephalgia syndromes; chronic headache; syndrome, headache; chronic daily headache; headache syndromes; daily headaches, chronic; headache disorder
Disease Class	8A80-8A84: Headache
Definition	Various conditions with the symptom of headache. Headache disorders are classified into major groups, such as primary headache disorders (based on characteristics of their headache symptoms) and secondary headache disorders (based on their etiologies). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
Disease Hierarchy	DIS4RWOW: Pain DISK4TGU: Headache
ICD Code	ICD-11 ICD-11: 8A80-8A84 Expand ICD-11 '8A8Z Expand ICD-10 'G40-G47; 'G43; 'G44; 'R51 Expand ICD-9 339784
Disease Identifiers	MONDO ID MONDO_0021146 MESH ID D020773 UMLS CUI C0393735 MedGen ID 140743 HPO ID HP:0002315 SNOMED CT ID 230461009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 19 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetaminophen	DMUIE76	Approved	Small molecular drug	[1]
Aspirin	DM672AH	Approved	Small molecular drug	[2]
Butalbital	DM9J04X	Approved	Small molecular drug	[3]
Caffeine	DMKBJWP	Approved	Small molecular drug	[4]
Codeine	DMJX6ZG	Approved	Small molecular drug	[5]
Dexibuprofen	DMFYBD0	Approved	Small molecular drug	[6]
Dextromethorphan	DMUDJZM	Approved	Small molecular drug	[7]
Ephedrine	DMMV0KW	Approved	Small molecular drug	[8]
Ergotamine	DMKR3C5	Approved	Small molecular drug	[9]
Ibuprofen	DM8VCBE	Approved	Small molecular drug	[10]
Mepyramine maleate	DM7F5OW	Approved	Small molecular drug	[11]
Naproxen	DMZ5RGV	Approved	Small molecular drug	[12]
Naratriptan	DMO50U2	Approved	Small molecular drug	[13]
Pheniramine	DMCH7RU	Approved	Small molecular drug	[14]
Phenylephrine	DMZHUO5	Approved	Small molecular drug	[15]
Pizotyline	DMV74ZH	Approved	Small molecular drug	[16]
Pseudoephedrine	DMIVJ0D	Approved	Small molecular drug	[8]
Salicyclic acid	DM2F8XZ	Approved	Small molecular drug	[17]
Salicylamide	DMQXO1I	Approved	Small molecular drug	[18]
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⏷ Show the Full List of 19 Drug(s)

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lithium	DMZ3OU6	Phase 2	Small molecular drug	[19]
NXN-462	DMWVBS2	Phase 2	NA	[20]
NOCICEPTIN	DMUPA7C	Phase 1	NA	[21]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CL-H02	DM0DO1N	Investigative	NA	[22]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
S100A12	TTQ4ESF	Strong	Biomarker	[23]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TRAF3IP2	OTLLZERL	Limited	Biomarker	[24]
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References

1	Acetaminophen FDA Label
2	Aspirin FDA Label
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7138).
4	Caffeine FDA Label
5	Codeine FDA Label
6	A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers. Eur J Clin Pharmacol. 2006 Oct;62(10):849-54.
7	Dextromethorphan FDA Label
8	Ephedrine FDA Label
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 149).
10	Ibuprofen FDA Label
11	Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79.
12	Naproxen FDA Label
13	Naratriptan FDA Label
14	Pheniramine FDA Label
15	Isoproterenol FDA Label
16	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 93).
17	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
18	Evaluation of acetaminophen-salicylamide combinations in treatment of headache. J Clin Pharmacol J New Drugs. 1967 May-Jun;7(3):150-5.
19	Lithium FDA Label
20	ClinicalTrials.gov (NCT01748877) Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia. U.S. National Institutes of Health.
21	ClinicalTrials.gov (NCT01404091) A Study of Nociceptin/Orphanin FQ Peptide Receptor Occupancy in Healthy Subjects. U.S. National Institutes of Health.
22	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
23	CGRP Monoclonal Antibodies for the Preventative Treatment of Migraine.Curr Pain Headache Rep. 2018 Apr 6;22(5):38. doi: 10.1007/s11916-018-0686-4.
24	Spotlight on cervical vagus nerve stimulation for the treatment of primary headache disorders: a review.J Pain Res. 2018 Aug 27;11:1613-1625. doi: 10.2147/JPR.S129202. eCollection 2018.