Details of Disease

Disease Name

Brain infarction

Definition

Tissue necrosis in any area of the brain, including the cerebral hemispheres, the cerebellum, and the brain stem. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by hypoxia and hypoglycemia in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.

Disease Hierarchy

DISAB237: Cerebrovascular disease

DISPPGYK: Brain infarction

Disease Identifiers

MONDO ID

MONDO_0005394

MESH ID

D020520

UMLS CUI

C0751955

MedGen ID

148426

General Information of Disease (ID: DISPPGYK)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 24 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDKL1	TTBTI6P	Limited	Genetic Variation	[1]
CHM	TTOA18V	Limited	Biomarker	[2]
GPR17	TTMPART	Limited	Therapeutic	[3]
PARG	TT39J16	Limited	Biomarker	[4]
PRKCH	TTONI0R	Limited	Genetic Variation	[5]
CYBB	TT5T8MR	moderate	Biomarker	[6]
FGF2	TTGKIED	moderate	Altered Expression	[7]
PLAT	TTXAGYU	moderate	Biomarker	[8]
ADIPOQ	TTXKA7D	Strong	Biomarker	[9]
ADK	TTL732K	Strong	Biomarker	[10]
AIF1	TT12MEP	Strong	Biomarker	[11]
BECN1	TT5M7LN	Strong	Biomarker	[12]
CTSB	TTF2LRI	Strong	Biomarker	[13]
HGF	TT4V2JM	Strong	Therapeutic	[14]
HNMT	TT2B6EV	Strong	ModifyingMutation	[15]
IGF2	TTE8WGO	Strong	Biomarker	[16]
MDK	TTV8UE7	Strong	Biomarker	[17]
MSI1	TTSM4BA	Strong	Biomarker	[18]
NES	TTHZ752	Strong	Biomarker	[19]
PDGFB	TTQA6SX	Strong	Biomarker	[20]
PLD1	TT3T17P	Strong	Altered Expression	[21]
PLD2	TTRLMKF	Strong	Altered Expression	[21]
SIRT1	TTUF2HO	Strong	Biomarker	[22]
TBXAS1	TTKNWZ4	Strong	Biomarker	[23]
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⏷ Show the Full List of 24 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A14	DTHSNUW	Limited	Altered Expression	[24]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ACP4	DE3OZT4	Limited	Biomarker	[25]
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This Disease Is Related to 11 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDK20	OTOLNN68	Limited	Genetic Variation	[1]
FZD1	OTZATHVS	Limited	Altered Expression	[26]
KLF11	OTKVQDJD	Limited	Biomarker	[27]
NUP43	OTDF5K8Y	Limited	Genetic Variation	[1]
PSMC6	OTG8997V	Limited	Genetic Variation	[1]
TAF8	OTWWGCHV	Limited	Biomarker	[28]
ADNP	OTEGICWR	Strong	Biomarker	[29]
GPLD1	OTUUQOVY	Strong	Altered Expression	[21]
MPZL2	OTKFNDUI	Definitive	Genetic Variation	[30]
SACM1L	OT6ORKTD	Definitive	Genetic Variation	[31]
TSPAN33	OTH6C0WU	Definitive	Biomarker	[32]
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⏷ Show the Full List of 11 DOT(s)

References

1	Thrombin Preconditioning Enhances Therapeutic Efficacy of Human Wharton's Jelly-Derived Mesenchymal Stem Cells in Severe Neonatal Hypoxic Ischemic Encephalopathy.Int J Mol Sci. 2019 May 20;20(10):2477. doi: 10.3390/ijms20102477.
2	SONOlysis in prevention of Brain InfaRctions During Internal carotid Endarterectomy (SONOBIRDIE) trial - study protocol for a randomized controlled trial.Trials. 2017 Jan 17;18(1):25. doi: 10.1186/s13063-016-1754-x.
3	The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One. 2008;3(10):e3579.
4	Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat. Brain Res. 2003 Jul 18;978(1-2):99-103.
5	Association between PRKCH gene polymorphisms and subcortical silent brain infarction.Atherosclerosis. 2008 Aug;199(2):340-5. doi: 10.1016/j.atherosclerosis.2007.11.009. Epub 2007 Dec 31.
6	Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.J Cereb Blood Flow Metab. 2009 Jul;29(7):1262-72. doi: 10.1038/jcbfm.2009.47. Epub 2009 May 6.
7	Intranasal basic fibroblast growth factor attenuates endoplasmic reticulum stress and brain injury in neonatal hypoxic-ischaemic injury.Am J Transl Res. 2017 Feb 15;9(2):275-288. eCollection 2017.
8	Neuroprotective effects of human neural stem cells over-expressing choline acetyltransferase in a middle cerebral artery occlusion model.J Chem Neuroanat. 2020 Jan;103:101730. doi: 10.1016/j.jchemneu.2019.101730. Epub 2019 Dec 16.
9	Adiponectin protects against cerebral ischemia-reperfusion injury through anti-inflammatory action.Brain Res. 2009 Jun 1;1273:129-37. doi: 10.1016/j.brainres.2009.04.002. Epub 2009 Apr 9.
10	Delayed treatment with an adenosine kinase inhibitor, GP683, attenuates infarct size in rats with temporary middle cerebral artery occlusion.Stroke. 1998 Sep;29(9):1952-8. doi: 10.1161/01.str.29.9.1952.
11	Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.Glia. 2009 Jun;57(8):835-49. doi: 10.1002/glia.20810.
12	Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats.Exp Neurol. 2012 Mar;234(1):181-90. doi: 10.1016/j.expneurol.2011.12.038. Epub 2011 Dec 29.
13	Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.Brain Res. 2010 Jan 22;1311:182-8. doi: 10.1016/j.brainres.2009.11.033. Epub 2009 Nov 24.
14	Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV-1 vector.J Cereb Blood Flow Metab. 2006 Sep;26(9):1176-88. doi: 10.1038/sj.jcbfm.9600273. Epub 2006 Jan 18.
15	Reduction of the infarct size by simultaneous administration of L-histidine and diphenhydramine in ischaemic rat brains.Resuscitation. 2011 Feb;82(2):219-21. doi: 10.1016/j.resuscitation.2010.10.024. Epub 2010 Dec 4.
16	Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain.Brain Res Mol Brain Res. 1995 Mar;29(1):81-91. doi: 10.1016/0169-328x(94)00232-4.
17	Midkine and retinoic acid reduce cerebral infarction induced by middle cerebral artery ligation in rats.Neurosci Lett. 2004 Oct 14;369(2):138-41. doi: 10.1016/j.neulet.2004.07.086.
18	Proliferation and differentiation of neural stem cells in adult rats after cerebral infarction.Chin Med Sci J. 2004 Jun;19(2):73-7.
19	[EphB2-Fc promotes activation of endogenous neural stem cells after cerebral cortex infarction: experimental with hypertensive rats].Zhonghua Yi Xue Za Zhi. 2005 Sep 7;85(34):2395-9.
20	The PDGF B-chain is involved in the ontogenic susceptibility of the developing rat brain to NMDA toxicity.Exp Neurol. 2004 Mar;186(1):89-98. doi: 10.1016/j.expneurol.2003.11.001.
21	Enzymatic Activity Is Not Required for Phospholipase D Mediated TNF- Regulation and Myocardial Healing.Front Physiol. 2018 Nov 29;9:1698. doi: 10.3389/fphys.2018.01698. eCollection 2018.
22	Acute resveratrol treatment modulates multiple signaling pathways in the ischemic brain.Neurochem Res. 2012 Dec;37(12):2686-96. doi: 10.1007/s11064-012-0858-2. Epub 2012 Aug 10.
23	Effect of ozagrel, a selective thromboxane A2-synthetase inhibitor, on cerebral infarction in rats. Comparative study with norphenazone, a free-radical scavenger.Arzneimittelforschung. 2003;53(10):688-94. doi: 10.1055/s-0031-1299813.
24	Amplified expression of uncoupling proteins in human brain ischemic lesions.Neuropathology. 2007 Oct;27(5):442-7. doi: 10.1111/j.1440-1789.2007.00815.x.
25	Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension.Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt A):93-101. doi: 10.1016/j.pnpbp.2018.02.006. Epub 2018 Feb 10.
26	Intranasal wnt3a Attenuates Neuronal Apoptosis through Frz1/PIWIL1a/FOXM1 Pathway in MCAO Rats.J Neurosci. 2018 Jul 25;38(30):6787-6801. doi: 10.1523/JNEUROSCI.2352-17.2018. Epub 2018 Jun 28.
27	Genetic Deletion of Krppel-Like Factor 11 Aggravates Ischemic Brain Injury.Mol Neurobiol. 2018 Apr;55(4):2911-2921. doi: 10.1007/s12035-017-0556-9. Epub 2017 Apr 29.
28	Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy.Neuromolecular Med. 2018 Mar;20(1):97-111. doi: 10.1007/s12017-018-8478-x. Epub 2018 Feb 6.
29	NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death.Stroke. 2002 Apr;33(4):1085-92. doi: 10.1161/01.str.0000014207.05597.d7.
30	Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness--the ECTIM, AXA, EVA and GENIC Studies.Eur J Hum Genet. 2004 Mar;12(3):213-9. doi: 10.1038/sj.ejhg.5201143.
31	Gene polymorphism of apolipoprotein AI, the major protein of high density lipoprotein in predicting stroke risk among white and black subjects.Stroke. 1993 Dec;24(12 Suppl):I26-30; discussion I31-2.
32	Neuroprotective Action of Human Wharton's Jelly-Derived Mesenchymal Stromal Cell Transplants in a Rodent Model of Stroke.Cell Transplant. 2018 Nov;27(11):1603-1612. doi: 10.1177/0963689718802754. Epub 2018 Oct 4.