Details of Disease

General Information of Disease (ID: DISQ1WRT)

Disease Name	Alcoholic cirrhosis of liver
Synonyms	Laennec's cirrhosis, alcoholic; portal cirrhosis; Laennec's cirrhosis; alcoholic cirrhosis of liver; alcoholic cirrhosis
Disease Class	DB94: Alcoholic liver disease
Definition	A disorder of the liver characterized by the presence of fibrotic scar tissue instead of healthy liver tissue. This condition is attributed to excessive consumption of alcoholic beverages.
Disease Hierarchy	DISXEPHQ: Alcoholic liver diseases DIS4G1GX: Liver cirrhosis DISQ1WRT: Alcoholic cirrhosis of liver
ICD Code	ICD-11 ICD-11: DB94
Disease Identifiers	MONDO ID MONDO_0006644 MESH ID D008104 UMLS CUI C0023891 MedGen ID 6125 SNOMED CT ID 420054005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Framycetin	DMF8DNE	Approved	Small molecular drug	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 9 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CAT	TTPS279	moderate	Biomarker	[2]
MPO	TTVCZPI	moderate	Biomarker	[2]
TM6SF2	TTE1OHM	moderate	Genetic Variation	[3]
GABRG2	TT06RH5	Strong	Genetic Variation	[4]
GPC3	TTJTSX4	Strong	Biomarker	[5]
MMP13	TTHY57M	Strong	Biomarker	[6]
MMP2	TTLM12X	Strong	Biomarker	[2]
SMAD3	TTHQZV7	Strong	Biomarker	[2]
SOD2	TT9O4C5	Strong	Genetic Variation	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 DTT(s)

This Disease Is Related to 4 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADH4	DEOCWU3	Strong	Genetic Variation	[8]
ADH5	DEIOH6A	Strong	Genetic Variation	[8]
AKR1A1	DED2FW3	Strong	Genetic Variation	[9]
CYP4A11	DE2XQGW	Strong	Altered Expression	[10]
------------------------------------------------------------------------------------

This Disease Is Related to 13 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SERPINB4	OT88LHZ8	Limited	Biomarker	[5]
MBOAT7	OTHRCBLK	moderate	Genetic Variation	[11]
PPP1R16B	OTZJFX5C	moderate	Genetic Variation	[12]
ARSH	OTG0X9UQ	Strong	Biomarker	[13]
CALCOCO2	OTRGX0OV	Strong	Genetic Variation	[14]
COL3A1	OTT1EMLM	Strong	Biomarker	[2]
ENHO	OT91QASK	Strong	Biomarker	[15]
PIAS3	OT3TWH9R	Strong	Altered Expression	[16]
RASGRF2	OT67DAGF	Strong	Genetic Variation	[17]
RELA	OTUJP9CN	Strong	Biomarker	[2]
SUGP1	OT7W0EB8	Strong	Genetic Variation	[18]
TIMP1	OTOXC51H	Strong	Biomarker	[2]
NCAN	OT8OO6ZE	Definitive	Genetic Variation	[19]
------------------------------------------------------------------------------------


⏷ Show the Full List of 13 DOT(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 709).
2	Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats.Toxicol Lett. 2013 Feb 27;217(2):102-10. doi: 10.1016/j.toxlet.2012.12.014. Epub 2012 Dec 26.
3	PNPLA3 rs738409 and TM6SF2 rs58542926 variants increase the risk of hepatocellular carcinoma in alcoholic cirrhosis.Dig Liver Dis. 2016 Jan;48(1):69-75. doi: 10.1016/j.dld.2015.09.009. Epub 2015 Sep 28.
4	Polymorphism in cytochrome P450 2E1 and interaction with other genetic risk factors and susceptibility to alcoholic liver cirrhosis.Mutat Res. 2009 May 12;664(1-2):55-63. doi: 10.1016/j.mrfmmm.2009.02.009. Epub 2009 Feb 28.
5	Diagnostic specificity and sensitivity of PIVKAII, GP3, CSTB, SCCA1 and HGF for the diagnosis of hepatocellular carcinoma in patients with alcoholic liver cirrhosis.Ann Clin Biochem. 2018 May;55(3):355-362. doi: 10.1177/0004563217726808. Epub 2017 Sep 20.
6	Expression pattern of matrix metalloproteinases-13 in a rat model of alcoholic liver fibrosis.Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):569-72.
7	Superoxide Dismutase 2 Genetic Variation as a Susceptibility Risk Factor for Alcoholic Cirrhosis.Alcohol Alcohol. 2016 Nov;51(6):633-637. doi: 10.1093/alcalc/agw004. Epub 2016 Feb 11.
8	Alcohol dehydrogenase: enzymology and metabolism.Alcohol Alcohol Suppl. 1994;2:113-9.
9	Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. doi: 10.1016/j.drugalcdep.2010.01.010. Epub 2010 Feb 18.
10	Expression of P450 and nuclear receptors in normal and end-stage Chinese livers.World J Gastroenterol. 2014 Jul 14;20(26):8681-90. doi: 10.3748/wjg.v20.i26.8681.
11	MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C.Nat Commun. 2016 Sep 15;7:12757. doi: 10.1038/ncomms12757.
12	Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.Genes (Basel). 2017 Jul 17;8(7):183. doi: 10.3390/genes8070183.
13	Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases.Hepatology. 2020 Jan;71(1):306-333. doi: 10.1002/hep.30866.
14	A variant in the nuclear dot protein 52kDa gene increases the risk for spontaneous bacterial peritonitis in patients with alcoholic liver cirrhosis.Dig Liver Dis. 2016 Jan;48(1):62-8. doi: 10.1016/j.dld.2015.09.011. Epub 2015 Sep 28.
15	Afamin and adropin in patients with alcohol-induced liver cirrhosis.Ann Agric Environ Med. 2018 Sep 25;25(3):527-531. doi: 10.26444/aaem/92650. Epub 2018 Jul 25.
16	Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis.J Hepatol. 2005 Oct;43(4):687-95. doi: 10.1016/j.jhep.2005.03.024.
17	A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men.PLoS One. 2016 Dec 19;11(12):e0168685. doi: 10.1371/journal.pone.0168685. eCollection 2016.
18	A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.Nat Genet. 2015 Dec;47(12):1443-8. doi: 10.1038/ng.3417. Epub 2015 Oct 19.
19	A common polymorphism in the NCAN gene is associated with hepatocellular carcinoma in alcoholic liver disease.J Hepatol. 2014 Nov;61(5):1073-9. doi: 10.1016/j.jhep.2014.06.006. Epub 2014 Jun 16.