Details of Disease

General Information of Disease (ID: DISVEAJA)

• Disease Name: Oral lichen planus
• Synonyms: olp - oral lichen planus; oral lichen planus
• Disease Class: EA91: Lichen planus
• Definition: A chronic, autoimmune inflammatory condition of the mucous membranes in the oral cavity that affects approximately two percent of the population and is most often seen in middle aged women. It is characterized by white, lacy patches; red, swollen tissue; papules and plaques; or open sores. The lesions are typically bilateral.
• Disease Hierarchy:
  DISRPMMS: Lichen planus
  DISX82BI: Mouth disorder
  DISVEAJA: Oral lichen planus
• ICD Code:
  ICD-11: ICD-11: EA91.4
  ICD-10: ICD-10: L43.8
  Expand ICD-11: 'EA91.42
  Expand ICD-10: 'L43.8
• Disease Identifiers:
  MONDO ID: MONDO_0043923
  MESH ID: D017676
  UMLS CUI: C0206139
  MedGen ID: 60084
  SNOMED CT ID: 235049008

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clobetasol	DMUXP52	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 12 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CYP2D6	TTVG215	Disputed	Biomarker	[2]
DEFB4A	TTIVY12	Disputed	Biomarker	[3]
ITGA11	TTANXZ7	moderate	Altered Expression	[4]
HDAC7	TTMUEK1	Strong	Altered Expression	[5]
PDE4B	TTVIAT9	Strong	Altered Expression	[6]
PLD2	TTRLMKF	Strong	Altered Expression	[7]
TNNC1	TT8RDXP	Strong	Biomarker	[8]
TSLP	TTHMW3T	Strong	Biomarker	[9]
GMPS	TTCFP0V	Definitive	Biomarker	[10]
HNMT	TT2B6EV	Definitive	Biomarker	[11]
HRH4	TTXJ178	Definitive	Biomarker	[12]
TGM1	TT7A949	Definitive	Biomarker	[13]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
TGM3	DEOEB3Q	Definitive	Biomarker	[13]

This Disease Is Related to 21 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CALML3	OTM8DNQU	Strong	Biomarker	[14]
COTL1	OT6YCNLF	Strong	Biomarker	[14]
CSRP3	OTECBJMV	Strong	Biomarker	[14]
CST2	OTRKRW50	Strong	Altered Expression	[15]
CTRL	OTB6NA5O	Strong	Biomarker	[16]
DSC1	OTNII6GZ	Strong	Altered Expression	[17]
FLG	OTE9QDV6	Strong	Biomarker	[18]
KRT15	OTS6WLF7	Strong	Biomarker	[19]
MAP1LC3B	OTUYHB84	Strong	Altered Expression	[20]
PPIG	OTZ8BTTM	Strong	Biomarker	[21]
TAS2R13	OTSTOX5G	Strong	Altered Expression	[22]
AANAT	OTUBJ7SX	Definitive	Altered Expression	[23]
ATG9B	OTJMJZW8	Definitive	Altered Expression	[24]
AWAT2	OTO5GKZS	Definitive	Altered Expression	[25]
BCL9L	OTTWI90E	Definitive	Biomarker	[10]
BUB3	OTU91HAU	Definitive	Biomarker	[26]
DSG1	OT11HC3A	Definitive	Altered Expression	[27]
HMGB4	OT28OBR2	Definitive	Biomarker	[26]
IVL	OT4VPNGY	Definitive	Biomarker	[13]
SRGAP2	OTUWFMCQ	Definitive	Biomarker	[28]
TSPAN33	OTH6C0WU	Definitive	Biomarker	[10]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Cytochrome P450 2D6 polymorphism and drug utilization in patients with oral lichen planus.Acta Odontol Scand. 2010 Jul;68(4):193-8. doi: 10.3109/00016351003636382.
• [3] Human -Defensin 2 Expression in Oral Epithelium: Potential Therapeutic Targets in Oral Lichen Planus.Int J Mol Sci. 2019 Apr 10;20(7):1780. doi: 10.3390/ijms20071780.
• [4] Integrin 11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression.J Oral Pathol Med. 2017 Apr;46(4):267-275. doi: 10.1111/jop.12493. Epub 2016 Oct 4.
• [5] Aberrant histone modification and inflammatory cytokine production of peripheral CD4+ T cells in patients with oral lichen planus.J Oral Pathol Med. 2019 Feb;48(2):136-142. doi: 10.1111/jop.12790. Epub 2018 Nov 8.
• [6] Expression and significance of phosphodiesterase 4B gene in peripheral blood of patients with oral lichen planus.Int J Dermatol. 2019 Mar;58(3):302-310. doi: 10.1111/ijd.14203. Epub 2018 Sep 19.
• [7] Deregulated phospholipase D2/mammalian target of rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with disease severity.Arch Oral Biol. 2019 Feb;98:26-31. doi: 10.1016/j.archoralbio.2018.11.003. Epub 2018 Nov 3.
• [8] Roles of the matricellular protein Tenascin-C in T-lymphocyte trafficking and etiopathogenesis of Oral Lichen Planus.Arch Oral Biol. 2020 Feb;110:104622. doi: 10.1016/j.archoralbio.2019.104622. Epub 2019 Nov 20.
• [9] Expression and clinical significance of periostin in oral lichen planus.Exp Ther Med. 2018 Jun;15(6):5141-5147. doi: 10.3892/etm.2018.6029. Epub 2018 Apr 3.
• [10] Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing.Oncol Rep. 2017 Apr;37(4):2355-2365. doi: 10.3892/or.2017.5487. Epub 2017 Mar 2.
• [11] Histamine metabolism and transport are deranged in human keratinocytes in oral lichen planus.Br J Dermatol. 2017 May;176(5):1213-1223. doi: 10.1111/bjd.14995. Epub 2017 Mar 22.
• [12] Histamine H4 receptor in oral lichen planus.Oral Dis. 2015 Apr;21(3):378-85. doi: 10.1111/odi.12290. Epub 2014 Oct 8.
• [13] Ectopic transglutaminase 1 and 3 expression accelerating keratinization in oral lichen planus.J Int Med Res. 2018 Nov;46(11):4722-4730. doi: 10.1177/0300060518798261. Epub 2018 Sep 13.
• [14] Distinct interferon-gamma and interleukin-9 expression in cutaneous and oral lichen planus.J Eur Acad Dermatol Venereol. 2017 May;31(5):880-886. doi: 10.1111/jdv.13989. Epub 2016 Oct 21.
• [15] Putative salivary protein biomarkers for the diagnosis of oral lichen planus: a case-control study.BMC Oral Health. 2018 Mar 13;18(1):42. doi: 10.1186/s12903-018-0504-8.
• [16] Evaluation of depression, anxiety and stress levels in patients with oral lichen planus.J Oral Sci. 2019 Aug 28;61(3):391-397. doi: 10.2334/josnusd.18-0113. Epub 2019 Jun 10.
• [17] Desmocollin expression in oral atrophic lichen planus correlates with clinical behavior and DNA content.J Cutan Pathol. 2008 Sep;35(9):832-8. doi: 10.1111/j.1600-0560.2007.00903.x. Epub 2008 Apr 18.
• [18] Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls.J Eur Acad Dermatol Venereol. 2017 May;31(5):887-893. doi: 10.1111/jdv.14098. Epub 2017 Jan 9.
• [19] Lichen planus: molecular pathway and clinical implications in oral disorders.J Biol Regul Homeost Agents. 2018 Jan-Feb;32(2 Suppl. 1):135-138.
• [20] miR?22 and miR?99 synergistically promote autophagy inoral lichen planus by targeting the Akt/mTOR pathway.Int J Mol Med. 2019 Mar;43(3):1373-1381. doi: 10.3892/ijmm.2019.4068. Epub 2019 Jan 21.
• [21] Polymorphic drug metabolizing CYP-enzymes--a pathogenic factor in oral lichen planus?.J Oral Pathol Med. 2009 Jan;38(1):63-71. doi: 10.1111/j.1600-0714.2008.00702.x.
• [22] Aberrant IGF1-PI3K/AKT/MTOR signaling pathway regulates the local immunity of oral lichen planus.Immunobiology. 2019 May;224(3):455-461. doi: 10.1016/j.imbio.2019.01.004. Epub 2019 Feb 10.
• [23] Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation.Arch Oral Biol. 2017 Jun;78:13-19. doi: 10.1016/j.archoralbio.2017.02.007. Epub 2017 Feb 6.
• [24] Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features.Mediators Inflamm. 2016;2016:4867368. doi: 10.1155/2016/4867368. Epub 2016 Feb 15.
• [25] Difficulties detecting miRNA-203 in human whole saliva by the use of PCR.Med Oral Patol Oral Cir Bucal. 2015 Mar 1;20(2):e130-4. doi: 10.4317/medoral.20172.
• [26] Oral lichen planus and malignant transformation: The role of p16, Ki-67, Bub-3 and SOX4 in assessing precancerous potential.Exp Ther Med. 2018 May;15(5):4157-4166. doi: 10.3892/etm.2018.5971. Epub 2018 Mar 20.
• [27] Phenotypic alteration of basal cells in oral lichen planus; switching keratin 19 and desmoglein 1 expression.J Oral Sci. 2018 Dec 27;60(4):507-513. doi: 10.2334/josnusd.17-0396. Epub 2018 Aug 25.
• [28] A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus.Arch Oral Biol. 2016 Aug;68:61-5. doi: 10.1016/j.archoralbio.2016.03.018. Epub 2016 Mar 30.