Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMN4ZKC)

Drug Name
PARAOXON Drug Info
Synonyms
PARAOXON; Phosphacol; Diethyl paraoxon; 311-45-5; Ethyl paraoxon; Diethyl 4-nitrophenyl phosphate; Phosphachole; Mintacol; Paraoxone; Miotisal; Fosfakol; Phosphakol; Oxyparathion; Chinorto; Diethyl p-nitrophenyl phosphate; Paroxan; Mintaco; Chinorta; Eticol; Miotisal A; Diethylparaoxon; Soluglaucit; Soluglacit; Paraoxon-ethyl; Ethyl paraoxan; p-Nitrophenyl diethyl phosphate; Phosphoric acid, diethyl 4-nitrophenyl ester; Ester 25; Pestox 101; E 600 (pesticide); Diethyl-p-nitrophenyl phosphate; Phosphoric acid diethyl 4-nitrophenyl ester
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9395
ChEBI ID
CHEBI:27827
CAS Number
CAS 311-45-5
TTD Drug ID
DMN4ZKC
INTEDE Drug ID
DR1241

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]
Cannabinoid receptor 1 (CB1) TT6OEDT CNR1_HUMAN Inhibitor [1]
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [3]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [3]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [3]
Fatty acid amide hydrolase (FAAH) TTDP1UC NOUNIPROTAC Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Investigative [4]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Investigative [5]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Investigative [4]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Investigative [4]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Investigative [4]
Serum paraoxonase/arylesterase 1 (PON1) DESDN74 PON1_HUMAN Investigative [6]
Serum paraoxonase/arylesterase 2 (PON2) DEHJU7E PON2_HUMAN Investigative [7]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Fatty acid amide hydrolase (FAAH) DTT FAAH 5.744 5.044 4.818 5.984
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Cannabinoid receptor 1 (CB1) DTT CNR1 2.907 4.667 2.982 3.678
Acetylcholinesterase (AChE) DTT ACHE 1.678 1.926 1.766 5.252
Cytochrome P450 2E1 (CYP2E1) DME CYP2E1 12.054 3.968 2.945 4.1
Serum paraoxonase/arylesterase 1 (PON1) DME PON1 9.887 3.248 4.594 4.146
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 9.791 3.744 3.413 1.609
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 10.036 5.779 6.508 6.481
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 10.08 7.207 5.403 9.211
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 11.692 6.58 4.984 9.089
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Acetylcholinesterase (AChE) DTT ACHE 6.39E-02 -1.07 -1.15
Cytochrome P450 2E1 (CYP2E1) DME CYP2E1 9.45E-02 -1.86E-01 -9.83E-01
Serum paraoxonase/arylesterase 1 (PON1) DME PON1 6.73E-01 -1.29E-02 -1.08E-01
Cytochrome P450 2C8 (CYP2C8) DME CYP2C8 5.57E-01 -7.89E-02 -7.93E-01
Cytochrome P450 1A2 (CYP1A2) DME CYP1A2 8.46E-01 -6.63E-03 -4.49E-02
Cytochrome P450 3A5 (CYP3A5) DME CYP3A5 9.57E-01 9.43E-03 1.29E-01
Serum paraoxonase/arylesterase 2 (PON2) DME PON2 7.02E-01 1.29E-01 4.19E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 1.76E-01 1.26E-01 8.27E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8.
2 Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8.
3 Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12.
4 Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology. 2006 Jul 5;224(1-2):22-32.
5 Interaction of ethanol and the organophosphorus insecticide parathion. Biochem Pharmacol. 1995 Nov 27;50(11):1925-32.
6 Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
7 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.