General Information of Drug (ID: DM0BHCJ)

Drug Name
Pyrrolidin-3-yl-acetic acid Drug Info
Synonyms
89203-64-5; 2-(pyrrolidin-3-yl)acetic acid; 3-PYRROLIDINEACETIC ACID; 3-Pyrrolidineaceticacid; Pyrrolidin-3-yl-acetic acid; 2-pyrrolidin-3-ylacetic Acid; pyrrolidin-3-ylacetic acid; CHEMBL351355; 2-(Pyrrolidin-3yl)acetic acid; Homo-beta-proline; ACMC-20liyx; ACMC-20mq1s; pyrrolidine-3-acetic acid; AC1N49FZ; SCHEMBL374930; CTK3E7957; OUENRUZPZZFMCA-UHFFFAOYSA-N; MolPort-001-729-044; KS-000003FH; BDBM50013224; 3-pyrrolidineacetic acid, AldrichCPR; 3-pyrrolidineacetic acid hydrochloride; AKOS005264421; MCULE-3887627276; RP19856
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4125298
TTD Drug ID
DM0BHCJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [2]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [3]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [2]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [2]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [4]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [2]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [2]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [5]
Meprobamate DMHM93Y Anxiety Approved [2]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [2]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [7]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [5]
Clonazepam DMTO13J Absence epilepsy Approved [8]
Piperazine DMTY9LU Ascariasis 1F62 Approved [9]
Alpidem DMN7Y9K Anxiety disorder 6B00-6B0Z Approved [10]
Moxidectin DMYGHX5 Onchocerciasis 1F6A Approved [11]
DP-VPA DMGOXPQ Bipolar disorder 6A60 Approved [12]
ANDROSTERONE DMITJAK N. A. N. A. Phase 3 [7]
ZK-93423 DMFWMKZ Epileptic seizures 8A61-8A6Z Phase 3 [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Inhibitor [1]
Gamma-aminobutyric acid receptor (GAR) TTNJYV2 NOUNIPROTAC Inhibitor [1]

References

1 Orally active and potent inhibitors of gamma-aminobutyric acid uptake. J Med Chem. 1985 May;28(5):653-60.
2 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
3 Zolpidem, a selective GABA(A) receptor alpha1 subunit agonist, induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat.Brain Res Bull.2006 Dec 11;71(1-3):200-7.
4 Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9.
5 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7 Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. J Med Chem. 2006 Jul 27;49(15):4595-605.
8 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
9 Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Agents. 2003 Sep;22(3):318-31.
10 Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new se... J Med Chem. 1997 Sep 12;40(19):3109-18.
11 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
12 DP-VPA D-Pharm. Curr Opin Investig Drugs. 2002 Jun;3(6):921-3.
13 Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9.