Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4M3C8)

Drug Name
furtrethonium Drug Info
Synonyms furmethide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10938
ChEBI ID
CHEBI:134764
CAS Number
CAS 7618-86-2
TTD Drug ID
DM4M3C8

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor (CHRM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [3]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [4]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [5]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [6]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [7]
Oxybutynin hydrochloride DMF2KLU Urinary incontinence MF50.2 Approved [8]
Incruse Ellipta DM32GSJ Chronic obstructive pulmonary disease CA22 Approved [9]
Revefenacin DMMP5SI Chronic obstructive pulmonary disease CA22 Approved [10]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [11]
Isopropamide iodide DMQYV60 Allergic rhinitis CA08.0 Approved [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [13]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [14]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [15]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [16]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [17]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [18]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [19]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [20]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [21]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [22]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [2]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Panobinostat DM58WKG Chronic graft versus host disease Approved [25]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Acetylcholine DMDF79Z Cataract 9B10 Approved [29]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [29]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Muscarinic acetylcholine receptor M4 (CHRM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALCURONIUM DM2U4XQ Anaesthesia 9A78.6 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Acetylcholine DMDF79Z Cataract 9B10 Approved [32]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [34]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [2]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [2]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [37]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [38]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [39]
Acetylcholine DMDF79Z Cataract 9B10 Approved [40]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [29]
Clozapine DMFC71L Schizophrenia 6A20 Approved [41]
Olanzapine DMPFN6Y Bipolar depression Approved [42]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [43]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [40]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscarinic acetylcholine receptor M2 (CHRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [44]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [24]
Acetylcholine DMDF79Z Cataract 9B10 Approved [32]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [46]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [2]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [48]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [35]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor (CHRM) TTOXS3C NOUNIPROTAC Agonist [2]
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Muscarinic acetylcholine receptor M1 (CHRM1) OTKW3E6B ACM1_HUMAN Drug Response [2]
Muscarinic acetylcholine receptor M2 (CHRM2) OTUMZ2WR ACM2_HUMAN Drug Response [2]
Muscarinic acetylcholine receptor M3 (CHRM3) OTKSD095 ACM3_HUMAN Drug Response [2]
Muscarinic acetylcholine receptor M4 (CHRM4) OTF0F0FF ACM4_HUMAN Drug Response [2]

References

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22 Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor ... Am J Physiol Gastrointest Liver Physiol. 2008 Jul;295(1):G112-G123.
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24 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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29 Assessment of false transmitters as treatments for nerve agent poisoning. Toxicol Lett. 2020 Mar 15;321:21-31. doi: 10.1016/j.toxlet.2019.12.010. Epub 2019 Dec 9.
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31 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
32 Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors. Life Sci. 1999;64(6-7):519-26. doi: 10.1016/s0024-3205(98)00596-7.
33 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
34 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
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