General Information of Drug (ID: DM7P3N5)

Drug Name
1-DODECANOL Drug Info
Synonyms
1-DODECANOL; Dodecyl alcohol; Dodecan-1-ol; Lauryl alcohol; Dodecanol; 112-53-8; n-Dodecyl alcohol; Lauric alcohol; Laurinic alcohol; Undecyl carbinol; Dodecylalcohol; Pisol; 1-Dodecyl alcohol; n-Dodecan-1-ol; Duodecyl alcohol; 1-Hydroxydodecane; Siponol L5; Karukoru 20; Siponol 25; Lorol 7; Lorol 5; n-Dodecanol; Lauryl 24; Alcohol C-12; Sipol L12; Lorol 11; Alfol 12; Siponol L2; Dytol J-68; Cachalot L-50; Cachalot L-90; Lauroyl alcohol; n-Lauryl alcohol; C12 alcohol; Hainol 12SS; Hydroxydodecane; Conol 20P; Lorol; Conol 20PP; Dodecyl alcoho
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
8193
ChEBI ID
CHEBI:28878
CAS Number
CAS 112-53-8
TTD Drug ID
DM7P3N5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [3]
Thiopental DMGP8AX Anaesthesia 9A78.6 Approved [4]
JNJ-42165279 DM72GZO Anxiety disorder 6B00-6B0Z Phase 2 [5]
SSR411298 DMGTB2Q Major depressive disorder 6A70.3 Phase 2 [6]
IW-6118 DMP42W1 Inflammation 1A00-CA43.1 Phase 2 [7]
PF-04457845 DMPRYU1 Liver disease DB90-BD99 Phase 2 [8]
IPI-940 DMEIM5G Pain MG30-MG3Z Phase 1 [9]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [10]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [10]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [10]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [11]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [13]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [14]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [15]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [16]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [17]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [18]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [19]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [24]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [28]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [34]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [29]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [36]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [2]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Selenium DM25CGV N. A. N. A. Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [26]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [38]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [39]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [40]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [2]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [41]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [20]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fatty acid amide hydrolase (FAAH) TTDP1UC NOUNIPROTAC Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Gene/Protein Processing [2]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Gene/Protein Processing [2]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Gene/Protein Processing [2]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [2]

References

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5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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28 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
29 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
30 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
31 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
32 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
33 Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
34 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
35 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
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37 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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40 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
41 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.