Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA1FRM)

Drug Name	PMID28460551-Compound-3 Drug Info
Cross-matching ID	PubChem CID 5083 ChEBI ID CHEBI:38912 CAS Number CAS 125314-64-9 TTD Drug ID DMA1FRM

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Patented Agent(s)

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Drug(s) Targeting Protein kinase C alpha (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[7]
Sotrastaurin acetate	DME53YS	Renal transplantation	NE84	Phase 2	[8]
ISIS 3521	DMZFS69	N. A.	N. A.	Discontinued in Phase 2	[9]
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[10]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[11]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[12]
Acteoside	DM0YHKB	Nephritis	GB40	Terminated	[13]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[14]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[15]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[20]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[25]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
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Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[41]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[42]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[43]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[37]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[46]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[47]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[48]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[53]
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Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
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Drug(s) Affected By E3 ubiquitin-protein ligase RNF187 (RNF187)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[66]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[3]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[67]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[3]
H-89	DM4RVGO	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Protein kinase C alpha (PRKCA)	TTFJ8Q1	KPCA_HUMAN	Inhibitor	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[2]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[2]
E3 ubiquitin-protein ligase RNF187 (RNF187)	OTXTN1HP	RN187_HUMAN	Protein Interaction/Cellular Processes	[3]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Gene/Protein Processing	[4]
Neurotensin/neuromedin N (NTS)	OTPGDNQS	NEUT_HUMAN	Gene/Protein Processing	[5]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Gene/Protein Processing	[6]

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