Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMAWTUL)

• Drug Name: Trifluoroethanol Drug Info
• Synonyms: 2,2,2-TRIFLUOROETHANOL; 75-89-8; Trifluoroethanol; Ethanol, 2,2,2-trifluoro-; Trifluoroethyl alcohol; 2,2,2-Trifluoroethan-1-Ol; Fluorinol 85; 2,2,2-Trifluoroethyl alcohol; trifluoro ethanol; TFE; Perfluoro-1,1-dihydroethanol; tfetoh; NSC 451; CF3CH2OH; 2,2,2-trifluoro-ethanol; beta,beta,beta-Trifluoroethyl alcohol; UNII-8T8I76KYF1; TFEA; 2,2,2-TRIFLUORETHANOL; 1h,1h-trifluoroethanol; EINECS 200-913-6; BRN 1733203; ethanol, 2,2,2-trifluoro; AI3-25486; 8T8I76KYF1; CHEBI:42330; RHQDFWAXVIIEBN-UHFFFAOYSA-N; MFCD00004672

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6409
  ChEBI ID: CHEBI:42330
  CAS Number: CAS 75-89-8
  TTD Drug ID: DMAWTUL

Molecule-Related Drug Atlas

Drug(s) Targeting Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[4]
3,5-dichlorosalicylic acid	DMQ45WH	Discovery agent	N.A.	Investigative	[5]
Cyclopropyl	DMGFEPJ	Discovery agent	N.A.	Investigative	[6]
Cyclobutyl	DM35PIJ	Discovery agent	N.A.	Investigative	[6]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[10]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[11]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[14]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[15]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[15]

Drug(s) Affected By Somatotropin (GH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[3]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[16]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[17]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Sodium oxybate	DMBOV5P	Narcolepsy	7A20	Approved	[20]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[3]
Connexyn	DMF29Q5	Attention deficit hyperactivity disorder	6A05.Z	Approved	[21]
Gamma Hydroxybutyric Acid	DMGBKVD	Narcolepsy	7A20	Approved	[22]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[23]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)	TTJS7O4	ADH2_ENTHI	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Protein Interaction/Cellular Processes	[2]
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Protein Interaction/Cellular Processes	[3]

References

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• [13] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [14] Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
• [15] Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression. Int J Mol Sci. 2018 May 4;19(5):1367. doi: 10.3390/ijms19051367.
• [16] Assessment of MK-912, an alpha 2-adrenoceptor antagonist, with use of intravenous clonidine. Clin Pharmacol Ther. 1989 Jul;46(1):103-9. doi: 10.1038/clpt.1989.113.
• [17] Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. J Biol Chem. 2003 Feb 21;278(8):6075-84. doi: 10.1074/jbc.M204702200. Epub 2002 Dec 5.
• [18] [Toxicity of cyproheptadine. Side effects and accidental overdosage (author's transl)]. Monatsschr Kinderheilkd (1902). 1978 Mar;126(3):123-6.
• [19] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [20] Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.
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