Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBUJVX)

• Drug Name: Phenoxodiol Drug Info
• Synonyms: Dehydroequol; Idronoxil; Haginin E; NV 06; NV-06; Idronoxil (USAN/INN); 2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl); 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; 3-(4-Hydroxyphenyl)-2H-chromen-7-ol; 7-hydroxy-3-hydroxyphenyl-1H-benzopyran

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 1/2	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 219100
  CAS Number: CAS 81267-65-4
  TTD Drug ID: DMBUJVX

Molecule-Related Drug Atlas

Drug(s) Targeting X-linked inhibitor of apoptosis protein (XIAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT-406	DMVJW0S	Squamous head and neck cell carcinom	2D60.0	Phase 3	[5]
Birinapant	DM6PBUM	Lymphoma	2A80-2A86	Phase 2	[6]
APG-1387	DMLEKUY	Haematological malignancy	2B33.Y	Phase 1	[7]
HGS-1029	DMS9WXG	Haematological malignancy	2B33.Y	Phase 1	[8]
GDC-0152	DM1B3UM	Obesity	5B81	Phase 1	[9]
PMID25980951-Compound-6	DMVSW5N	N. A.	N. A.	Patented	[10]
PMID25980951-Compound-27	DMXAH9F	N. A.	N. A.	Patented	[10]
PMID25980951-Compound-43	DMTJRCS	N. A.	N. A.	Patented	[10]
PMID25980951-Compound-1	DMYPT2H	N. A.	N. A.	Patented	[10]
PMID25980951-Compound-44	DMS5896	N. A.	N. A.	Patented	[10]

Drug(s) Targeting Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[11]
PMID27539678-Compound-6	DMBKNDE	N. A.	N. A.	Patented	[12]
Methylbenzenesulfonamide derivative 1	DMUNME2	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-12	DMNIKTA	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-10	DM61SR0	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-16	DMMDJH8	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-14	DMZ02LA	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-13	DM1J2V8	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-11	DMIKAJC	N. A.	N. A.	Patented	[12]
PMID27539678-Compound-7	DMQAC4K	N. A.	N. A.	Patented	[12]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[21]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[22]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]

Drug(s) Affected By Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[37]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[38]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[41]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sphingosine kinase 1 (SPHK1)	TTOHFIY	SPHK1_HUMAN	Modulator	[2]
X-linked inhibitor of apoptosis protein (XIAP)	TTR7B60	XIAP_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[3]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Gene/Protein Processing	[3]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Protein Interaction/Cellular Processes	[3]
Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)	OTMDA97Z	ENOX2_HUMAN	Gene/Protein Processing	[4]

References

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