General Information of Drug (ID: DMC1WHR)

Drug Name
[3H]QNB Drug Info
Synonyms
3-Quinuclidinyl benzilate; 6581/6/2; 3-Chinuclidylbenzilate; 3-Quinuclidyl benzilate; 3-quinuclidinylbenzilate; 3-Quinuclidinol benzilate; Ro 2-3308; CHEMBL12980; Benzilic acid, 3-quinuclidinyl ester; (+/-)-QNB; NSC 173698; QNB; EA 2277; CS 4030; BZ; 1-Azabicyclo(222)octan-3-ol, benzilate; Buzz; Agent BZ; 1-azabicyclo[222]octan-3-yl 2-hydroxy-2,2-diphenylacetate; BZ [anticholinergic]; 4478-53-9; NSC170423; Benzilic acid, 3-quinuclidinyl ester, (+-)-; 3-quinuclidinyl-benzilate; [3H]quinuclidinylbenzilate; Benzeneacetic; [3H]quinuclidinylbenzilate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
23056
CAS Number
CAS 6581-06-2
TTD Drug ID
DMC1WHR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [5]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [6]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [7]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [8]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [9]
Oxybutynin hydrochloride DMF2KLU Urinary incontinence MF50.2 Approved [10]
Incruse Ellipta DM32GSJ Chronic obstructive pulmonary disease CA22 Approved [11]
Revefenacin DMMP5SI Chronic obstructive pulmonary disease CA22 Approved [12]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [13]
Isopropamide iodide DMQYV60 Allergic rhinitis CA08.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [15]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [16]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [17]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [18]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [19]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [20]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [21]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [22]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [23]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [24]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [25]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Panobinostat DM58WKG Chronic graft versus host disease Approved [28]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [29]
Testosterone DM7HUNW Hot flushes GA30 Approved [30]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [30]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [31]
Acetylcholine DMDF79Z Cataract 9B10 Approved [32]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [32]
⏷ Show the Full List of 20 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [33]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [33]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Acetylcholine DMDF79Z Cataract 9B10 Approved [35]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [36]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [37]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [25]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [38]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALCURONIUM DM2U4XQ Anaesthesia 9A78.6 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Acetylcholine DMDF79Z Cataract 9B10 Approved [35]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [43]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [25]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [25]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [39]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [44]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [41]
Acetylcholine DMDF79Z Cataract 9B10 Approved [46]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [33]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [39]
[3H]dimethyl-W84 DMBWAIE Discovery agent N.A. Investigative [33]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [47]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [48]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [49]
Acetylcholine DMDF79Z Cataract 9B10 Approved [50]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [32]
Clozapine DMFC71L Schizophrenia 6A20 Approved [51]
Olanzapine DMPFN6Y Bipolar depression Approved [52]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [53]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [50]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [25]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor (CHRM) TTOXS3C NOUNIPROTAC Antagonist [2]
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Muscarinic acetylcholine receptor M1 (CHRM1) OTKW3E6B ACM1_HUMAN Protein Interaction/Cellular Processes [4]
Muscarinic acetylcholine receptor M2 (CHRM2) OTUMZ2WR ACM2_HUMAN Protein Interaction/Cellular Processes [4]
Muscarinic acetylcholine receptor M3 (CHRM3) OTKSD095 ACM3_HUMAN Protein Interaction/Cellular Processes [4]
Muscarinic acetylcholine receptor M4 (CHRM4) OTF0F0FF ACM4_HUMAN Protein Interaction/Cellular Processes [4]
Muscarinic acetylcholine receptor M5 (CHRM5) OTNQRQGG ACM5_HUMAN Protein Interaction/Cellular Processes [4]

References

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21 Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.
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25 Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol. 1997 Jul;52(1):172-9.
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27 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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31 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
32 Assessment of false transmitters as treatments for nerve agent poisoning. Toxicol Lett. 2020 Mar 15;321:21-31. doi: 10.1016/j.toxlet.2019.12.010. Epub 2019 Dec 9.
33 Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity. Mol Pharmacol. 2006 Jul;70(1):181-93. doi: 10.1124/mol.106.023481. Epub 2006 Apr 26.
34 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
35 Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors. Life Sci. 1999;64(6-7):519-26. doi: 10.1016/s0024-3205(98)00596-7.
36 In Vitro and In Vivo Assessments of Cardiovascular Effects with Omadacycline. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5247-53. doi: 10.1128/AAC.00320-16. Print 2016 Sep.
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38 Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one, in cellular and in vivo models of pulmonary oxidative stress. J Pharmacol Exp Ther. 2017 Oct;363(1):114-125.
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47 Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor. J Med Chem. 2004 Aug 12;47(17):4300-15. doi: 10.1021/jm040800a.
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50 Regional differences in functional receptor distribution and calcium mobilization in the intact human lens. Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2355-63.
51 Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action. Neuroreport. 2002 May 7;13(6):831-5. doi: 10.1097/00001756-200205070-00019.
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