Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME5QPX)

• Drug Name: BENZOLAMIDE Drug Info
• Synonyms: BENZOLAMIDE; 3368-13-6; UNII-FC5AAH89R5; CL 11366; FC5AAH89R5; 2-benzenesulfonamido-1,3,4-thiadiazole-5-sulfonamide; CHEMBL73962; 1,3,4-Thiadiazole-2-sulfonamide, 5-[(phenylsulfonyl)amino]-; W 1803; 5-(phenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide; 2-(Phenylsulfonylamino)-1,3,4-thiadiazole-5-sulfonamide; 5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide; 1,3,4-Thiadiazole-2-sulfonamide, 5-((phenylsulfonyl)amino)-; 5-benzenesulfonamido-1,3,4-thiadiazol-2-sulfonamide; 3dbu; D8W; Benzolamide (BZA); 3d8w; AC1L2CTC

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 18794
  CAS Number: CAS 3368-13-6
  TTD Drug ID: DME5QPX

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[2]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[12]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[10]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[13]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[10]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[15]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[15]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[16]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[15]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[17]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[18]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[10]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[10]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[18]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[3]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[19]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[20]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[20]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[21]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[22]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[23]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[10]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[13]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[10]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[24]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[2]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[25]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[26]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[10]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[27]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[28]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[15]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[29]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[26]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[10]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[9]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[10]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[9]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[11]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[30]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[31]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[32]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[33]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[34]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[3]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[4]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[5]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[2]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[2]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[6]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[7]

References

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• [8] Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
• [9] Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
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• [15] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
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• [17] Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12.
• [18] Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
• [19] Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
• [20] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [21] Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
• [22] Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
• [23] Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
• [24] Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3593-6.
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• [29] Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):573-8.
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• [31] Potential role of (124)I-girentuximab in the presurgical diagnosis of clear-cell renal cell cancer. Biologics. 2012;6:395-407.
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