Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEB837)

Drug Name

Cefotaxime Drug Info

Synonyms

Cefotaxima; Cefotaxima [INN-Spanish]; Cefotaxime [INN:BAN]; Cefotaxime acid; Cefotaximum; Cefotaximum [INN-Latin]; Cephotaxime; E-cefotaxime; Omnatax; RU 24662; RU 24756; cefotaxime; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-(((2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-, (6R,7R)-; 60846-21-1; 63527-52-6; C16H17N5O7S2; CHEBI:204928; EINECS 264-299-1; HR 756; N2GI8B1GK7; Taxim; UNII-N2GI8B1GK7

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial arthritis		Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Escherichia coli meningitis		Approved	[1]
Meningococcal meningitis		Approved	[1]
Neonatal sepsis		Approved	[1]
Peritonitis		Approved	[1]
Staphylococcal pneumonia		Approved	[1]

Cross-matching ID

PubChem CID: 5742673
ChEBI ID: CHEBI:204928
CAS Number: CAS 60846-21-1
TTD Drug ID: DMEB837
INTEDE Drug ID: DR2226

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial DD-carboxypeptidase (Bact vanYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[18]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[19]
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[20]
TD-1792	DMGKBZH	Skin infection	1F28-1G0Z	Phase 3	[21]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[22]
Cephalosporin C	DMYW3ZG	Discovery agent	N.A.	Investigative	[23]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[24]
D-Alanine	DMVIDQL	Discovery agent	N.A.	Investigative	[24]
3-boronobenzoic acid	DMRCJW0	Discovery agent	N.A.	Investigative	[22]
NITROCEFIN	DM7M5VY	Discovery agent	N.A.	Investigative	[25]
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Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[10]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[11]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[4]
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[4]
Levofloxacin	DMS60RB	Acute maxillary sinusitis		Approved	[4]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[4]
Cotrimoxazole	DMSW5QP	N. A.	N. A.	Phase 4	[4]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[5]
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[5]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[5] , [6]
Cefpirome	DMJKWPZ	N. A.	N. A.	Phase 4	[6]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[26]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[27]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[8]
Avibactam	DM1AEH4	N. A.	N. A.	Approved	[9] , [28]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[8]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[12]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[12]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[12]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[12]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[12]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[12]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[29]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[12]
Ertapenem	DM4S3O8	Bacterial infection	1A00-1C4Z	Approved	[30]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[6]
Cefpirome	DMJKWPZ	N. A.	N. A.	Phase 4	[6]
Imipenem	DMI9FBP	Bacteremia	1A73	Approved	[27]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[14]
Piperacillin	DMTBKF3	Acute gonococcal cervicitis		Approved	[14]
Tazobactam	DM3XNUI	Appendicitis	DB10	Approved	[14]
Cefoxitin	DMY8NC4	Acute gonococcal cervicitis		Approved	[31]
Cephaloridine	DM4Y95F	Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[16]
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Drug(s) Metabolized By PenA beta-lactamase (penA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[16]
Oxacillin	DMTAFY4	Bacterial infection	1A00-1C4Z	Approved	[16]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DD-carboxypeptidase (Bact vanYB)	TTLP6GN	VANY_ENTFA	Inhibitor	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-lactamase (blaB)	DEP0IWS	A0A378EHS6_KLEPR	Substrate	[4]
Beta-lactamase (blaB)	DEEAL81	BLA2_KLEPO	Substrate	[5] , [6]
Beta-lactamase (blaB)	DEKGVS4	PENA_BURM1	Substrate	[7]
Beta-lactamase (blaB)	DE7IH52	AMPC_CITFR	Substrate	[8] , [9]
Beta-lactamase (blaB)	DEAYSTX	C0W968_9FIRM	Substrate	[10]
Beta-lactamase (blaB)	DEITMS0	Q9XBM2_ACIFE	Substrate	[11]
Beta-lactamase (blaB)	DE5HV8P	A0A4Q5I6I2_9BACE	Substrate	[12]
Beta-lactamase (blaB)	DE47ARF	B5WXV2_9BACT	Substrate	[12]
Beta-lactamase (blaB)	DEG2PK9	B5WXV3_BACOV	Substrate	[12]
Beta-lactamase (blaB)	DEWHJ7A	B5WXV7_BACT4	Substrate	[12] , [13]
Beta-lactamase (blaB)	DEU1RXB	BLAC_BACVU	Substrate	[12]
Beta-lactamase (blaB)	DEMIUB2	BLAT_ECOLX	Substrate	[6]
Beta-lactamase (blaB)	DEYIEO5	AMPC_SERMA	Substrate	[14]
Beta-lactamase (blaB)	DEZLFV5	B8R6A5_9BURK	Substrate	[15]
Ampc beta-lactamase (ampC)	DE0TCN3	B4EPS2_BURCJ	Substrate	[15]
PenA beta-lactamase (penA1)	DE2ARDZ	O08350_BURCE	Substrate	[16]
Beta-lactamase (blaB)	DEVHXAU	BLC2_SALTM	Substrate	[13]
Beta-lactamase (blaB)	DEHJVX4	A0A414C8Y0_9BACT	Substrate	[12]
Beta-lactamase (blaB)	DE5AHG6	BLAC_CITKO	Substrate	[17]

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References

1	Cefotaxime FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064200.
3	Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol. 2007 Jun;2:297-307.
4	Analysis of the drug-resistant characteristics of Klebsiella pneumoniae isolated from the respiratory tract and CTX-M ESBL genes. Genet Mol Res. 2015 Oct 5;14(4):12043-8.
5	Antibiotic resistance and production of extended-spectrum beta-lactamases amongst Klebsiella spp. from intensive care units in Europe. J Antimicrob Chemother. 1996 Sep;38(3):409-24.
6	Oral streptococcal strains isolated from odontogenic infections and their susceptibility to antibiotics. Rev Med Chir Soc Med Nat Iasi. 2006 Oct-Dec;110(4):1012-5.
7	Overcoming an extremely drug resistant (XDR) pathogen: avibactam restores susceptibility to ceftazidime for Burkholderia cepacia complex isolates from cystic fibrosis patients. ACS Infect Dis. 2017 Jul 14;3(7):502-511.
8	Citrobacter freundii bacteremia: Risk factors of mortality and prevalence of resistance genes. J Microbiol Immunol Infect. 2018 Aug;51(4):565-572.
9	Analyses of a ceftazidime-avibactam-resistant Citrobacter freundii isolate carrying blaKPC-2 reveals a heterogenous population and reversible genotype. mSphere. 2018 Sep 26;3(5). pii: e00408-18.
10	ACI-1 beta-lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages. Environ Microbiol. 2018 Jun;20(6):2288-2300.
11	ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci. Antimicrob Agents Chemother. 2000 Nov;44(11):3144-9.
12	Presence of the cfxA gene in Bacteroides distasonis. Res Microbiol. 2003 Jun;154(5):369-74.
13	Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics. J Antimicrob Chemother. 2015 Mar;70(3):701-9.
14	Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130.
15	Cell wall recycling-linked coregulation of AmpC and PenB beta-lactamases through ampD mutations in Burkholderia cenocepacia. Antimicrob Agents Chemother. 2015 Dec;59(12):7602-10.
16	Characterization of the penA and penR genes of Burkholderia cepacia 249 which encode the chromosomal class A penicillinase and its LysR-type transcriptional regulator. Antimicrob Agents Chemother. 1997 Nov;41(11):2399-405.
17	Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrob Agents Chemother. 2005 Apr;49(4):1564-6.
18	Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry. 1995 Jul 25;34(29):9532-40.
19	Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
20	A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31.
21	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
22	Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106.
23	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
24	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
25	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
26	Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiol Lett. 2005 Jan 15;242(2):319-24.
27	Antibiotic therapy for inducible AmpC beta-lactamase-producing Gram-negative bacilli: what are the alternatives to carbapenems, quinolones and aminoglycosides? Int J Antimicrob Agents. 2012 Oct;40(4):297-305.
28	Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
29	Prevalence of antimicrobial resistance genes in Bacteroides spp. and Prevotella spp. Dutch clinical isolates. Clin Microbiol Infect. 2019 Sep;25(9):1156.e9-1156.e13.
30	War wound treatment complications due to transfer of an IncN plasmid harboring bla(OXA-181) from Morganella morganii to CTX-M-27-producing sequence type 131 Escherichia coli. Antimicrob Agents Chemother. 2015;59(6):3556-62.
31	Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent beta-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother. 2004 Jun;53(6):1076-80.