Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIK367)

Drug Name

Procarbazine Drug Info

Synonyms

Ibenzmethyzin; Ibenzmethyzine; MBH; MIH; Natulan; Natulanar; PCX; Procarbazin; Procarbazina; Procarbazinum; Procarbazin [German]; Procarbazine Monohydrochloride; CB 400-497; Indicarb (TN); Matulane (TN); Natulan (TN); Procarbazina [INN-Spanish]; Procarbazine (INN); Procarbazine [INN:BAN]; Procarbazinum [INN-Latin];Ro 4-6467; SRI-10847; Ro 4-6467/1; N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine; N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide; P-(2-Methylhydrazinomethyl)-N-isopropylbenzamide; N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide; P-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide; N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide; N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide; N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide; Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-(9CI); 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine; 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine; 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide; 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide

Indication

Disease Entry	ICD 11	Status	REF
Hodgkin lymphoma	2B30	Approved	[1]

Therapeutic Class

Anticancer Agents

Cross-matching ID

PubChem CID: 4915
ChEBI ID: CHEBI:71417
CAS Number: CAS 671-16-9
TTD Drug ID: DMIK367
INTEDE Drug ID: DR1344
ACDINA Drug ID: D00558

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Human Deoxyribonucleic acid (hDNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[6]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[7]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[8]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[9]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[10]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[11]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[12]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[13]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[14]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[15]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[16]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[21]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[22]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[23]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[24]
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Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[22]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[29]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[30]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[31]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[32]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[33]
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Drug(s) Metabolized By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[22]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[30]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[31]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[35]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[36]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[37]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[38]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[37]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Not Available	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[3]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[3]
Cytochrome P450 1B1 (CYP1B1)	DE9QHP6	CP1B1_HUMAN	Substrate	[4]

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References

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