Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJIA6T)

Drug Name
Barbiturate Drug Info
Synonyms
Barbituric acid; BARBITURIC ACID; 67-52-7; Malonylurea; 6-Hydroxyuracil; 2,4,6(1H,3H,5H)-Pyrimidinetrione; Pyrimidinetrione; pyrimidine-2,4,6(1H,3H,5H)-trione; 2,4,6-Pyrimidinetrione; Malonylharnstoff; 2,4,6-Trioxohexahydropyrimidine; 1,3-diazinane-2,4,6-trione; Barbitursaeure; Hexahydropyrimidine-2,4,6-trione; Hydrouracil, 6-hydroxy-; Barbituric acid (VAN); Urea, N,N'-(1,3-dioxo-1,3-propanediyl)-; NSC 7889; UNII-WQ92Y2793G; 2,4,6-Pyrimidinetrione(1H,3H,5H); Barbituric acid (VAN) (8CI); CHEBI:16294; EINECS 200-658-0; Barbitursaeure; Pyrimidinetriol; Barbiturate anion; Sodiumbarbiturate; AG-670/31547005; Hexahydro-pyrimidine-2,4,6-trione; Pyrimidine-2,4,6(1H,3H,5H)-trione; 1,2,3,4,5,6-Hexahydro-2,4,6-pyrimidinetrione; 11709_FLUKA; 2,4,6-(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Pyrimidinetriol; 2,4,6-Trihydroxypyrimidine; 2,4,6-trioxotetrahydro-2H-pyrimidin-1-ide; 4,6-dioxo-1H-pyrimidin-2-olate
Indication
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [1]
Depression 6A70-6A7Z Approved [2]
Cross-matching ID
PubChem CID
6211
ChEBI ID
CHEBI:16294
CAS Number
CAS 67-52-7
TTD Drug ID
DMJIA6T

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [2]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [3]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [2]
Nitrazepam DMEGIQ6 Epilepsy 8A60-8A68 Approved [2]
Allopregnanolone DMNLHAC Depression 6A70-6A7Z approved [4]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [2]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [2]
THIOCOLCHICOSIDE DMEPWYA Muscle spasm MB47.3 Approved [5]
Meprobamate DMHM93Y Anxiety Approved [2]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glutamate receptor AMPA (GRIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [7]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [8]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [9]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [10]
Enflurane DM0YJSB Anaesthesia 9A78.6 Approved [11]
Isoflurane DMY6T31 Anaesthesia 9A78.6 Approved [12]
Bromazepam DMY9TCW Anxiety disorder 6B00-6B0Z Approved [13]
Artemisinin SP DMFETDK Malaria 1F40-1F45 Approved [14]
Dihydroergotoxine DM5D6WZ Alzheimer disease 8A20 Approved [15]
Fospropofol disodium DMKLJRD Monitored anaesthesia care N.A. Approved [16]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
GABA(A) receptor alpha-1 (GABRA1) TT1MPAY GBRA1_HUMAN Antagonist [2]
Glutamate receptor AMPA (GRIA) TTAN6JD NOUNIPROTAC Agonist [1]

References

1 Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
2 DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
3 Zolpidem, a selective GABA(A) receptor alpha1 subunit agonist, induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat.Brain Res Bull.2006 Dec 11;71(1-3):200-7.
4 Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9.
5 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7 Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45.
8 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
9 Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441-453.
10 Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35.
11 Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84.
12 Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5.
13 Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 2009 May;204(1):61-71.
14 GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32.
15 Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97.
16 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015