Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMU6BJ)

• Drug Name: Sodium bicarbonate Drug Info
• Synonyms: Acidosan; Colovage; Glycoprep; Golytely; Jusonin; Meylon; Natriumhydrogenkarbonat; Natron; Neut; Nulytely; Soludal; BSS plus; Baking soda; Bicarbonate of soda; Carbonic acid monosodium salt; Gripe water; Lithium bicarbonate; Monosodium hydrogen carbonate; Natrii hydrogencarbonas; Natrium bicarbonicum; Natrium hydrogencarbonicum; Natrum bicarbonicum; Sandoz sodium bicarbonate; Sel De vichy; Soda Mint; Sodium acid carbonate; Sodium bicarbonate in plastic container; Sodium bicarbonate liquid concentrate; Sodium bicarbonate solution; Sodium hydrocarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate; NaHCO3; Bicarbonate, Sodium; Carbonic acid, monosodium salt; Co-lav; Col-evac; Go-evac; Hema BP-38; Hydrogen Carbonate, Sodium; Meylon (TN); Neut (TN); Peg-lyte; Soda (van); Soda, Baking; Sodium bicarbonate [USAN:JAN]; Carbonic acid sodium salt (1:1); E-Z-EM Prep Lyte; Sodium bicarbonate (1:1); Sodium bicarbonate (JP15/USP); Sodium carbonate (Na(HCO3)); 800 Sodium Bicarbonate Powder

Indication

Disease Entry	ICD 11	Status	REF
Metabolic acidosis	5C73	Approved	[1]

• Therapeutic Class: Antidiarrheals
• Cross-matching ID:
  PubChem CID: 516892
  ChEBI ID: CHEBI:32139
  CAS Number: CAS 144-55-8
  TTD Drug ID: DMMU6BJ
  VARIDT Drug ID: DR00038
  ACDINA Drug ID: D00629

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flunarizine	DMZU5JP	Migraine	8A80	Approved	[9]
ABT-639	DMEWQ4X	Pain	MG30-MG3Z	Phase 2	[10]
Mibefradil	DMU9VDS	Glioblastoma multiforme	2A00.0	Phase 1	[11]
TTA-A8	DMWZCIF	Insomnia	7A00-7A0Z	Preclinical	[12]
U-92032	DMTYO3P	N. A.	N. A.	Terminated	[13]
ML218	DM3D21X	Discovery agent	N.A.	Investigative	[14]
KYS-05001	DM3MID9	Discovery agent	N.A.	Investigative	[15]
KYS-05077	DMHW40F	Discovery agent	N.A.	Investigative	[16]
KYS-05080	DM57BXZ	Discovery agent	N.A.	Investigative	[16]
Cis-N,5-dibenzyl-6-oxomorpholine-3-carboxamide	DM75SO4	Discovery agent	N.A.	Investigative	[17]

Drug(s) Targeting Voltage-gated potassium channel Kv4.3 (KCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CDE-5498	DMVHTQI	Heart arrhythmia	BC65	Terminated	[18]

Drug(s) Affected By Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[28]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H)	TTZPWGN	CAC1H_HUMAN	Blocker	[2]
Voltage-gated potassium channel Kv4.3 (KCND3)	TTPLQO0	KCND3_HUMAN	Blocker	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)	DTW40Z7	S4A8_HUMAN	Substrate	[4]
Sodium-driven chloride bicarbonate exchanger (SLC4A10)	DT7RYVF	S4A10_HUMAN	Substrate	[5]
Anion exchange protein 4 (SLC4A9)	DTSQY0W	B3A4_HUMAN	Substrate	[6]
Sodium bicarbonate cotransporter 3 (SLC4A7)	DT03V27	S4A7_HUMAN	Substrate	[4]
Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5)	DTCL4P8	S4A5_HUMAN	Substrate	[4]
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	DTWDEIL	S4A4_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4)	OT727K92	S4A4_HUMAN	Regulation of Drug Effects	[8]

References

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• [19] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [20] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
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• [24] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
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