Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNUMDG)

Drug Name
BW A4C Drug Info
Synonyms
BW4C; Bwa-4C; Bwa 4C; 106328-57-8; BW-A4C; BWA4C; CHEMBL314360; C17H17NO3; N-(E)-3-(3-Phenoxyphenyl)prop-2-enylacetohydroxamine acid; Acetamide, N-hydroxy-N-(3-(3-phenoxyphenyl)-2-propenyl)-; N-[(E)-3-(3-Phenoxyphenyl)prop-2-enyl]acetohydroxamic acid; Acetohydroxamine acid, N-(E)-3-(3-phenoxyphenyl)prop-2-enyl-; Acetamide, N-hydroxy-N-(3-(3-phenoxyphenyl)-2-propenyl)-, (E)-; BW-4AC; AC1O5PJ5; BW-A-4C; BW-A 4C; JMC515449 Compound 7; BDBM22334; ZINC5138195; MFCD00869694; N-(3-phenoxycinnamyl)-N-hydroxyacetamide
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Terminated [1]
Cross-matching ID
PubChem CID
6438354
CAS Number
CAS 106328-57-8
TTD Drug ID
DMNUMDG

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [5]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [6]
Silymarin DMXBYQR N. A. N. A. Phase 4 [7]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [8]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [9]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [10]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [11]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [12]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [13]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting LOX-5 messenger RNA (ALOX5 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
TEBUFELONE DMMUE8P Pain MG30-MG3Z Discontinued in Phase 2 [15]
ZD-2138 DMVFCX7 Asthma CA23 Discontinued in Phase 2 [16]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [17]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 Discovery agent N.A. Investigative [18]
METHYLHONOKIOL DM9YE6K Discovery agent N.A. Investigative [18]
HONOKIOL DMJWT3X Discovery agent N.A. Investigative [18]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [19]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [19]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [19]
5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD Discovery agent N.A. Investigative [18]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [22]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [23]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [24]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [27]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [28]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [29]
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Drug(s) Affected By ALK tyrosine kinase receptor (ALK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [30]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [2]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [2]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [33]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [34]
Arsenic DMTL2Y1 N. A. N. A. Approved [35]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [36]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [37]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [38]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [39]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [40]
Fructose DM43AN2 Vomiting MD90 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [45]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [46]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [47]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [2]
LOX-5 messenger RNA (ALOX5 mRNA) TTSJ6Q4 LOX5_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [2]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5) OT7FOIK2 LOX5_HUMAN Gene/Protein Processing [4]

References

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29 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
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