Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQGBM1)

• Drug Name: EVT-201 Drug Info
• Synonyms: IDDBCP221837

Indication

Disease Entry	ICD 11	Status	REF
Insomnia	7A00-7A0Z	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 9885841
  CAS Number: CAS 308239-86-3
  TTD Drug ID: DMQGBM1

Molecule-Related Drug Atlas

Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[3]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[4]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[5]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[3]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[6]
Thiamylal	DMHDF7B	Anaesthesia	9A78.6	Approved	[5]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[4]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[5]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[5]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[5]

Drug(s) Targeting GABA(A) receptor alpha-1 (GABRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[7]
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[8]
Methoxyflurane	DML0RAE	Anaesthesia	9A78.6	Approved	[7]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[7]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[9]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[7]
Hexobarbital	DMQ314B	Anaesthesia	9A78.6	Approved	[7]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[10]
Meprobamate	DMHM93Y	Anxiety		Approved	[7]
Zaleplon	DMGFWSM	Insomnia	7A00-7A0Z	Approved	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Modulator	[2]
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Modulator	[3]

References

• [1] ClinicalTrials.gov (NCT00380003) Efficacy Study of EVT 201 to Treat Insomnia. U.S. National Institutes of Health.
• [2] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [6] Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia. 2006 Apr;47(4):704-16.
• [7] DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6.
• [8] Zolpidem, a selective GABA(A) receptor alpha1 subunit agonist, induces comparable Fos expression in oxytocinergic neurons of the hypothalamic paraventricular and accessory but not supraoptic nuclei in the rat.Brain Res Bull.2006 Dec 11;71(1-3):200-7.
• [9] Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (... J Med Chem. 2005 Apr 21;48(8):3051-9.
• [10] 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7.