Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQTREB)

Drug Name
Uridine Drug Info
Synonyms
uridine; 58-96-8; Uridin; Uracil riboside; beta-Uridine; d-uridine; CHEBI:16704; b-Uridine; UNII-WHI7HQ7H85; Urd; AI3-52690; EINECS 200-407-5; WHI7HQ7H85; MLS000069625; Uracil-1-beta-d-ribofuranoside; C9H12N2O6; DRTQHJPVMGBUCF-XVFCMESISA-N; SMR000058222; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Cross-matching ID
PubChem CID
6029
ChEBI ID
CHEBI:16704
CAS Number
CAS 58-96-8
TTD Drug ID
DMQTREB
VARIDT Drug ID
DR00321
INTEDE Drug ID
DR2135

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Thymidine phosphorylase (TYMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
5-bromo-6-hydrazinouracil hydrochloride DMZJE6M Discovery agent N.A. Investigative [11]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil DMEV0GO Discovery agent N.A. Investigative [12]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione DM90JMN Discovery agent N.A. Investigative [13]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione DMASFR6 Discovery agent N.A. Investigative [13]
1-(cyclohexyl)methyl-5'-O-tritylinosine DMS3XUC Discovery agent N.A. Investigative [14]
1-(cyclopropyl)methyl-5'-O-tritylinosine DMDU3X7 Discovery agent N.A. Investigative [14]
1-propyl-5'-O-tritylinosine DM5P01L Discovery agent N.A. Investigative [14]
1-allyl-5'-O-tritylinosine DM2J5WH Discovery agent N.A. Investigative [14]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione DMCKODQ Discovery agent N.A. Investigative [13]
6-chloro-5-(2-thienyl)pyrimidine-2,4(1H,3H)-dione DMSZML2 Discovery agent N.A. Investigative [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Concentrative nucleoside transporter 1 (SLC28A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [15]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [16]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [17]
Drug(s) Transported By Concentrative nucleoside transporter 2 (SLC28A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [18]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [19]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [20]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [21]
Drug(s) Metabolized By Nicotinamide riboside kinase 2 (NRK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [6]
cytidine DMK0W8E Discovery agent N.A. Investigative [6]
D-ribosylnicotinate DMYOLEV N. A. N. A. Investigative [6]
Drug(s) Metabolized By Nicotinamide riboside kinase 1 (NRK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tiazofurin DM5JWV9 Solid tumour/cancer 2A00-2F9Z Approved [6]
cytidine DMK0W8E Discovery agent N.A. Investigative [6]
D-ribosylnicotinate DMYOLEV N. A. N. A. Investigative [6]
Drug(s) Metabolized By Uridine-cytidine kinase 2 (UCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
cytidine DMK0W8E Discovery agent N.A. Investigative [5]
Drug(s) Metabolized By Uridine-cytidine kinase 1 (UCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
cytidine DMK0W8E Discovery agent N.A. Investigative [5]
Drug(s) Affected By Sodium/nucleoside cotransporter 1 (SLC28A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [24]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [25]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [26]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [26]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [27]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [27]
DEOXYCYTIDINE DMYE5LJ Acute myeloid leukaemia 2A60 Approved [8]
Urethane DM7NSI0 N. A. N. A. Phase 4 [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/nucleoside cotransporter 2 (SLC28A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Arsenic DMTL2Y1 N. A. N. A. Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [32]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [9]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [9]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [33]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [34]
Purine Riboside DMHNS0V Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Epinephrine DM3KJBC Acute asthma CA23 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [40]
Fructose DM43AN2 Vomiting MD90 Approved [41]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [43]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleoside transporter 1 (SLC29A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [45]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [46]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [50]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [51]
Testosterone DM7HUNW Hot flushes GA30 Approved [52]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [52]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleoside transporter 2 (SLC29A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [23]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [53]
Arsenic DMTL2Y1 N. A. N. A. Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [55]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [56]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [57]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [58]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thymidine phosphorylase (TYMP) TTO0IB8 TYPH_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [3]
Concentrative nucleoside transporter 2 (SLC28A2) DT82KPY S28A2_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Uridine-cytidine kinase 1 (UCK1) DE478BP UCK1_HUMAN Substrate [5]
Nicotinamide riboside kinase 1 (NRK1) DENV24I NRK1_HUMAN Substrate [6]
Nicotinamide riboside kinase 2 (NRK2) DE8DJ3N NRK2_HUMAN Substrate [6]
Uridine-cytidine kinase 2 (UCK2) DETN1O0 UCK2_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Regulation of Drug Effects [7]
Equilibrative nucleoside transporter 2 (SLC29A2) OTUAOB8T S29A2_HUMAN Regulation of Drug Effects [7]
Sodium/nucleoside cotransporter 1 (SLC28A1) OTXWVV9O S28A1_HUMAN Regulation of Drug Effects [8]
Sodium/nucleoside cotransporter 2 (SLC28A2) OTFYZK8R S28A2_HUMAN Regulation of Drug Effects [9]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [10]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4566).
2 Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
3 Electrophysiological recordings of CNT1 (SLC28A1) activity on Nanions SURFE2R N1.
4 Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters. Biochem Pharmacol. 2019 May;163:60-70.
5 Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol. 2001 May;59(5):1181-6.
6 Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263.
7 Nucleoside transport in human colonic epithelial cell lines: evidence for two Na+-independent transport systems in T84 and Caco-2 cells. Biochim Biophys Acta. 1999 Jun 9;1419(1):15-22. doi: 10.1016/s0005-2736(99)00045-0.
8 Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):415-34. doi: 10.1080/15257770008033018.
9 Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol Membr Biol. 1998 Oct-Dec;15(4):203-11. doi: 10.3109/09687689709044322.
10 Apoptosis induced by nucleosides in the human hepatoma HepG2. World J Gastroenterol. 2005 Oct 28;11(40):6381-4. doi: 10.3748/wjg.v11.i40.6381.
11 Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
12 The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
13 Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
14 5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.
15 FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
16 Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers (Basel). 2017 Nov 16;9(11).
17 Lonsurf, INN-trifluridine/tipiracil.
18 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
19 Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
20 Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. Pharmacogenet Genomics. 2007 Sep;17(9):783-6.
21 Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals.
22 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
23 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
24 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
25 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
26 Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Am J Physiol. 1997 Feb;272(2 Pt 1):C707-14. doi: 10.1152/ajpcell.1997.272.2.C707.
27 Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation. Mol Cancer Ther. 2009 Jan;8(1):225-31. doi: 10.1158/1535-7163.MCT-08-0743.
28 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
29 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
30 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
31 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
32 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
33 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
34 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
35 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
36 The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
37 NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
38 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
39 Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
40 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
41 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
42 Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1071-7. doi: 10.1097/01.meg.0000231750.68513.6c.
43 Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
44 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
45 Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model. Pancreas. 2006 Aug;33(2):142-7. doi: 10.1097/01.mpa.0000226882.48204.26.
46 Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res. 2008 Apr 1;68(7):2349-57. doi: 10.1158/0008-5472.CAN-07-5528.
47 Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS One. 2011 Jan 24;6(1):e16331. doi: 10.1371/journal.pone.0016331.
48 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
49 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
50 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
51 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
52 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
53 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
54 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
55 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
56 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
57 Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem J. 1997 Dec 15;328 ( Pt 3)(Pt 3):739-43. doi: 10.1042/bj3280739.
58 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.