Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQUAP2)

• Drug Name: 4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine Drug Info
• Synonyms: CHEMBL598346; 4-(2-fluoro-6-(2-fluorophenoxy)phenyl)piperidine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 46230654
  TTD Drug ID: DMQUAP2

Molecule-Related Drug Atlas

Drug(s) Targeting Norepinephrine transporter (NET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[2]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[3]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[4]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[2]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[5]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[6]
Tapentadol hydrochloride	DMXLSH3	Acute pain	MG31	Approved	[7]
Venlafaxine	DMR6QH0	Anxiety disorder	6B00-6B0Z	Approved	[6]
Trimipramine	DM1SC8M	Major depressive disorder	6A70.3	Approved	[8]
Duloxetine	DM9BI7M	Depression	6A70-6A7Z	Approved	[9]

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[2]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[3]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[10]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[11]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[12]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[5]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[6]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[10]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[10]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[10]

Drug(s) Targeting Dopamine transporter (DAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[5]
Dasotraline	DMLDQFV	Attention deficit hyperactivity disorder	6A05.Z	Approved	[13]
Methylphenidate	DM7SJD6	Attention deficit hyperactivity disorder	6A05.Z	Approved	[14]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[10]
Phenmetrazine	DMXYTN9	Obesity	5B81	Approved	[15]
Ioflupane i-123	DMNARJT	Parkinson disease	8A00.0	Approved	[16]
DEXMETHYLPHENIDATE HYDROCHLORIDE	DM8WBAH	Attention deficit hyperactivity disorder	6A05.Z	Approved	[17]
Altropane	DMO9WDS	Attention deficit hyperactivity disorder	6A05.Z	Approved	[18]
Amitifadine	DMS1X67	Obesity	5B81	Phase 3	[19]
NAV5001	DMRSI1M	Dementia	6D80-6D86	Phase 3	[18]

Drug(s) Targeting 5-HT 1A receptor (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[10]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[20]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[21]
Vilazodone	DM4LECQ	Major depressive disorder	6A70.3	Approved	[22]
Flibanserin	DM70DTN	Depression	6A70-6A7Z	Approved	[11]
Gepirone	DMGX5Q0	Major depressive disorder	6A70.3	Approved	[23]
TERTATOLOL	DM2L3D5	Hypertension	BA00-BA04	Approved	[24]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[25]
Treximet	DMU54QB	Migraine	8A80	Approved	[26]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[27]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
Dopamine transporter (DAT)	TTVBI8W	SC6A3_HUMAN	Inhibitor	[1]
Norepinephrine transporter (NET)	TTAWNKZ	SC6A2_HUMAN	Inhibitor	[1]
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[1]

References

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• [21] Effects of brexpiprazole, a novel serotonin-dopamine activity modulator, on phencyclidine-induced cognitive deficits in mice: a role for serotonin 5-HT1A receptors.Pharmacol Biochem Behav.2014 Sep;124:245-9.
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