Details of the Drug-Related molecule(s) Interaction Atlas

Nitrite Drug Info

LS-193697; NO2(-); Nitrit; Nitrite (8CI,9CI); Nitrite Ion; Nitrite anion; Nitrite ion (NO2-); Nitrite(1-); Nitrites; Nitrogen Oxide Anion; Nitrogen dioxide ion(1-); Nitrogen peroxide ion(1-); Nitrous acid, ion(1-); dioxidonitrate(1-); dioxonitrate(1-); dioxonitrate(III); nitrite; 14797-65-0; 1937AH; AB01566909_01; AC1L1ADT; BDBM26989; CHEBI:16301; CHEMBL1361; CTK0H5378; DB12529; DTXSID5024219; MFCD00144923; NCGC00090737-03; NCGC00090737-04; NO2; NO2-; ONO-; UNII-J39976L608; IOVCWXUNBOPUCH-UHFFFAOYSA-M; J39976L608; [NO2](-)

Cross-matching ID

PubChem CID

946

ChEBI ID

CHEBI:16301

CAS Number

CAS 14797-65-0

TTD Drug ID

DMR5XT3

INTEDE Drug ID

DR2117

General Information of Drug (ID: DMR5XT3)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[5]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[6]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[7]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[10]
Selenium	DM25CGV	N. A.	N. A.	Approved	[11]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[12]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[13]
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Drug(s) Affected By Low affinity immunoglobulin epsilon Fc receptor (FCER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[14]
Methacholine Chloride	DMGS4QH	Asthma	CA23	Approved	[15]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[16]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[19]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[20]
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Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[26]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[27]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[28]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[29]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[30]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
MOSC domain-containing protein 1 (MARC1)	DE1VDSF	MARC1_HUMAN	Substrate	[1]
MOSC domain-containing protein 2 (MARC2)	DE6QH2D	MARC2_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Regulation of Drug Effects	[2]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Regulation of Drug Effects	[3]
Low affinity immunoglobulin epsilon Fc receptor (FCER2)	OTU40XWZ	FCER2_HUMAN	Biotransformations	[4]

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References

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16	Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
17	Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
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19	Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
20	Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
21	Anemia and erythropoiesis in patients with the acquired immunodeficiency syndrome (AIDS) and Kaposi sarcoma treated with zidovudine. Ann Intern Med. 1988 Mar;108(3):372-6. doi: 10.7326/0003-4819-108-3-372.
22	Role of hydrogen peroxide in hypoxia-induced erythropoietin production. Biochem J. 1994 Oct 15;303 ( Pt 2)(Pt 2):507-10. doi: 10.1042/bj3030507.
23	Normal erythropoietin response in chronic hepatitis C patients with ribavirin-induced anaemia. Antivir Ther. 2003 Feb;8(1):57-63.
24	Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
25	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
26	Role of erythropoietin in cortisol-induced hypertension. J Hum Hypertens. 2000 Mar;14(3):195-8. doi: 10.1038/sj.jhh.1000959.
27	Fenoterol but not dobutamine increases erythropoietin production in humans. Clin Pharmacol Ther. 1997 Jun;61(6):669-76. doi: 10.1016/S0009-9236(97)90102-8.
28	Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am J Clin Nutr. 2006 Sep;84(3):580-6. doi: 10.1093/ajcn/84.3.580.
29	Worsening of anemia by angiotensin converting enzyme inhibitors and its prevention by antiestrogenic steroid in chronic hemodialysis patients. J Cardiovasc Pharmacol. 1989;13 Suppl 3:S27-30. doi: 10.1097/00005344-198900133-00007.
30	Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood. 2009 Nov 19;114(21):4639-44. doi: 10.1182/blood-2009-04-218040. Epub 2009 Sep 1.