Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWQ480)

Drug Name

schisandrin A Drug Info

Synonyms

(-)-deoxyschisandrin; (-)-dimethylgomisin J

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 155256
CAS Number: CAS 61281-38-7
TTD Drug ID: DMWQ480

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Targeting Pregnane X receptor (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[5]
Hyperforin	DM2L3PE	Discovery agent	N.A.	Investigative	[6]
3-keto-lithocholic acid	DM5LUED	Discovery agent	N.A.	Investigative	[7]
pregnenolone-16alpha-carbonitrile	DM0LW7G	Discovery agent	N.A.	Investigative	[8]
trihydroxycholestane	DMSP56N	Discovery agent	N.A.	Investigative	[9]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[10]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[13]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[15]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[19]
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Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[29]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[13]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[15]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[36]
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Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[19]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pregnane X receptor (NR1I2)	TT7LCTF	NR1I2_HUMAN	Agonist	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[3]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Post-Translational Modifications	[3]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)	OTLUM9L7	PK3C3_HUMAN	Post-Translational Modifications	[4]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Post-Translational Modifications	[4]
Vimentin	OTGZLW4J	VIME_HUMAN	Gene/Protein Processing	[4]

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References

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34	Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol. 2021 Jul;41(7):1076-1088. doi: 10.1002/jat.4094. Epub 2020 Oct 19.
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37	Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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40	Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
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