Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWQ480)

Drug Name
schisandrin A Drug Info
Synonyms (-)-deoxyschisandrin; (-)-dimethylgomisin J
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
155256
CAS Number
CAS 61281-38-7
TTD Drug ID
DMWQ480

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Pregnane X receptor (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
WAY-214950 DM8ODI7 Discovery agent N.A. Investigative [6]
Hyperforin DM2L3PE Discovery agent N.A. Investigative [7]
3-keto-lithocholic acid DM5LUED Discovery agent N.A. Investigative [8]
pregnenolone-16alpha-carbonitrile DM0LW7G Discovery agent N.A. Investigative [9]
trihydroxycholestane DMSP56N Discovery agent N.A. Investigative [10]
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [11]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [12]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [13]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [14]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [15]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [16]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [17]
Capsaicin DMGMF6V Back pain ME84.Z Approved [18]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [19]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [24]
Paclitaxel DMLB81S Breast carcinoma Approved [25]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [26]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [28]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [29]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [32]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [38]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [44]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [45]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [49]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [55]
Selenium DM25CGV N. A. N. A. Approved [56]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [34]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [62]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [63]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [64]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [65]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [68]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [69]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [72]
Selenium DM25CGV N. A. N. A. Approved [56]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [73]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [57]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [76]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [24]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [77]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [78]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [79]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [80]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [81]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [59]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Testosterone enanthate DMB6871 N. A. N. A. Approved [83]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Capsaicin DMGMF6V Back pain ME84.Z Approved [85]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [87]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [89]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [90]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [91]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [39]
Selenium DM25CGV N. A. N. A. Approved [56]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [96]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [30]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [98]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [54]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Meloxicam DM2AR7L Arthritis FA20 Approved [100]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [101]
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Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [105]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [106]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [110]
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Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [113]
Testosterone DM7HUNW Hot flushes GA30 Approved [114]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [115]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Capsaicin DMGMF6V Back pain ME84.Z Approved [85]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [86]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [87]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [117]
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Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [122]
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [116]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [125]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [91]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Pregnane X receptor (NR1I2) TT7LCTF NR1I2_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Post-Translational Modifications [3]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) OTU1KZPV AAPK2_HUMAN Post-Translational Modifications [3]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [4]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [4]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [4]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [5]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Gene/Protein Processing [4]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [4]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Post-Translational Modifications [4]

References

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4 MEG3 is restored by schisandrin A and represses tumor growth in choriocarcinoma cells. J Biochem Mol Toxicol. 2020 Apr;34(4):e22455. doi: 10.1002/jbt.22455. Epub 2020 Feb 14.
5 Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther. 2006 Mar;316(3):1369-77.
6 Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8.
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21 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
22 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
23 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
24 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
25 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
26 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
27 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
28 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
29 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
30 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
31 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
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34 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
35 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
36 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
37 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
38 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
39 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
40 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
41 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
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43 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
44 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
45 Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
46 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
47 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
48 Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
49 Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
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51 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
52 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
53 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
54 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
55 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
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