Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTGZLW4J)

DOT Name Vimentin
Gene Name VIM
Related Disease
Cataract 30 ( )
Pulverulent cataract ( )
UniProt ID
VIME_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
1GK4; 1GK6; 1GK7; 3G1E; 3KLT; 3S4R; 3SSU; 3SWK; 3TRT; 3UF1; 4MCY; 4MCZ; 4MD0; 4MD5; 4MDI; 4MDJ; 4YPC; 4YV3; 5WHF; 6ATF; 6ATI; 6BIR; 6YXK
Pfam ID
PF00038 ; PF04732
Sequence
MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGV
YATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDK
VRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAE
DIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEE
EIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSE
AANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQD
TIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSS
LNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDDLE
Function
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.
Tissue Specificity
Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
KEGG Pathway
Cytoskeleton in muscle cells (hsa04820 )
Epstein-Barr virus infection (hsa05169 )
MicroR.s in cancer (hsa05206 )
Reactome Pathway
Striated Muscle Contraction (R-HSA-390522 )
Interleukin-4 and Interleukin-13 signaling (R-HSA-6785807 )
RHOBTB1 GTPase cycle (R-HSA-9013422 )
Chaperone Mediated Autophagy (R-HSA-9613829 )
Late endosomal microautophagy (R-HSA-9615710 )
Aggrephagy (R-HSA-9646399 )
Caspase-mediated cleavage of cytoskeletal proteins (R-HSA-264870 )

Molecular Interaction Atlas (MIA) of This DOT

2 Disease(s) Related to This DOT
Disease Name Disease ID Evidence Level Mode of Inheritance REF
Cataract 30 DISIXL03 Strong Autosomal dominant [1]
Pulverulent cataract DISMJ2AH Supportive Autosomal dominant [1]
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Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 5 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Aspirin DM672AH Approved Vimentin increases the Gastrointestinal tract mucosal discolouration ADR of Aspirin. [90]
Topotecan DMP6G8T Approved Vimentin affects the response to substance of Topotecan. [91]
PEITC DMOMN31 Phase 2 Vimentin affects the binding of PEITC. [92]
Sulforaphane DMQY3L0 Investigative Vimentin affects the binding of Sulforaphane. [92]
4-hydroxy-2-nonenal DM2LJFZ Investigative Vimentin affects the binding of 4-hydroxy-2-nonenal. [93]
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90 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate decreases the expression of Vimentin. [2]
Ciclosporin DMAZJFX Approved Ciclosporin increases the expression of Vimentin. [3]
Tretinoin DM49DUI Approved Tretinoin decreases the expression of Vimentin. [4]
Doxorubicin DMVP5YE Approved Doxorubicin increases the expression of Vimentin. [5]
Cisplatin DMRHGI9 Approved Cisplatin decreases the expression of Vimentin. [6]
Estradiol DMUNTE3 Approved Estradiol increases the expression of Vimentin. [7]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of Vimentin. [8]
Arsenic DMTL2Y1 Approved Arsenic increases the expression of Vimentin. [9]
Quercetin DM3NC4M Approved Quercetin decreases the expression of Vimentin. [10]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide decreases the expression of Vimentin. [11]
Calcitriol DM8ZVJ7 Approved Calcitriol decreases the expression of Vimentin. [12]
Vorinostat DMWMPD4 Approved Vorinostat decreases the expression of Vimentin. [2]
Testosterone DM7HUNW Approved Testosterone increases the expression of Vimentin. [13]
Triclosan DMZUR4N Approved Triclosan affects the expression of Vimentin. [14]
Methotrexate DM2TEOL Approved Methotrexate increases the expression of Vimentin. [15]
Decitabine DMQL8XJ Approved Decitabine decreases the expression of Vimentin. [16]
Marinol DM70IK5 Approved Marinol decreases the expression of Vimentin. [17]
Zoledronate DMIXC7G Approved Zoledronate increases the expression of Vimentin. [18]
Selenium DM25CGV Approved Selenium increases the expression of Vimentin. [19]
Menadione DMSJDTY Approved Menadione decreases the expression of Vimentin. [20]
Fluorouracil DMUM7HZ Approved Fluorouracil increases the expression of Vimentin. [21]
Dexamethasone DMMWZET Approved Dexamethasone decreases the expression of Vimentin. [22]
Folic acid DMEMBJC Approved Folic acid increases the expression of Vimentin. [23]
Niclosamide DMJAGXQ Approved Niclosamide decreases the expression of Vimentin. [24]
Rosiglitazone DMILWZR Approved Rosiglitazone affects the expression of Vimentin. [25]
Diclofenac DMPIHLS Approved Diclofenac decreases the expression of Vimentin. [26]
Nicotine DMWX5CO Approved Nicotine decreases the expression of Vimentin. [27]
Azacitidine DMTA5OE Approved Azacitidine increases the expression of Vimentin. [28]
Capsaicin DMGMF6V Approved Capsaicin decreases the expression of Vimentin. [29]
Alitretinoin DMME8LH Approved Alitretinoin decreases the expression of Vimentin. [30]
Palbociclib DMD7L94 Approved Palbociclib increases the expression of Vimentin. [31]
Acocantherin DM7JT24 Approved Acocantherin decreases the expression of Vimentin. [32]
Phenytoin DMNOKBV Approved Phenytoin increases the expression of Vimentin. [33]
Sorafenib DMS8IFC Approved Sorafenib decreases the expression of Vimentin. [34]
Cholecalciferol DMGU74E Approved Cholecalciferol decreases the expression of Vimentin. [36]
Warfarin DMJYCVW Approved Warfarin decreases the expression of Vimentin. [37]
Tacrolimus DMZ7XNQ Approved Tacrolimus increases the expression of Vimentin. [38]
Crizotinib DM4F29C Approved Crizotinib decreases the expression of Vimentin. [39]
Bleomycin DMNER5S Approved Bleomycin increases the expression of Vimentin. [40]
Sodium chloride DMM3950 Approved Sodium chloride increases the expression of Vimentin. [41]
LY2835219 DM93VBZ Approved LY2835219 increases the expression of Vimentin. [42]
Ketamine DMT5HA4 Approved Ketamine increases the expression of Vimentin. [43]
Resveratrol DM3RWXL Phase 3 Resveratrol decreases the expression of Vimentin. [44]
Tamibarotene DM3G74J Phase 3 Tamibarotene decreases the expression of Vimentin. [4]
Fenretinide DMRD5SP Phase 3 Fenretinide decreases the expression of Vimentin. [36]
HMPL-004 DM29XGY Phase 3 HMPL-004 decreases the expression of Vimentin. [45]
I3C DMIGFOR Phase 3 I3C decreases the expression of Vimentin. [46]
Amiodarone DMUTEX3 Phase 2/3 Trial Amiodarone increases the expression of Vimentin. [47]
Thymoquinone DMVDTR2 Phase 2/3 Thymoquinone decreases the expression of Vimentin. [48]
Belinostat DM6OC53 Phase 2 Belinostat increases the expression of Vimentin. [49]
phorbol 12-myristate 13-acetate DMJWD62 Phase 2 phorbol 12-myristate 13-acetate increases the expression of Vimentin. [50]
G1 DMTV42K Phase 1/2 G1 decreases the expression of Vimentin. [51]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 decreases the expression of Vimentin. [53]
Arecoline DMFJZK3 Phase 1 Arecoline increases the expression of Vimentin. [54]
PMID26394986-Compound-10 DMP8RQ4 Patented PMID26394986-Compound-10 affects the expression of Vimentin. [55]
UNC0379 DMD1E4J Preclinical UNC0379 increases the expression of Vimentin. [56]
PJ34 DMXO6YH Preclinical PJ34 decreases the expression of Vimentin. [57]
Wortmannin DM8EVK5 Terminated Wortmannin decreases the expression of Vimentin. [58]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of Vimentin. [59]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of Vimentin. [60]
Coumarin DM0N8ZM Investigative Coumarin decreases the expression of Vimentin. [61]
chloropicrin DMSGBQA Investigative chloropicrin decreases the expression of Vimentin. [62]
Deguelin DMXT7WG Investigative Deguelin increases the expression of Vimentin. [63]
Paraquat DMR8O3X Investigative Paraquat increases the expression of Vimentin. [64]
D-glucose DMMG2TO Investigative D-glucose increases the expression of Vimentin. [65]
Lithium chloride DMHYLQ2 Investigative Lithium chloride decreases the expression of Vimentin. [66]
Chlorpyrifos DMKPUI6 Investigative Chlorpyrifos increases the expression of Vimentin. [67]
Tributylstannanyl DMHN7CB Investigative Tributylstannanyl decreases the expression of Vimentin. [30]
Microcystin-LR DMTMLRN Investigative Microcystin-LR increases the expression of Vimentin. [69]
Dibutyl phthalate DMEDGKO Investigative Dibutyl phthalate increases the expression of Vimentin. [70]
Aminohippuric acid DMUN54G Investigative Aminohippuric acid affects the expression of Vimentin. [71]
Cordycepin DM72Y01 Investigative Cordycepin decreases the expression of Vimentin. [72]
Chrysin DM7V2LG Investigative Chrysin decreases the expression of Vimentin. [73]
15-deoxy-Delta(12, 14)-prostaglandin J(2) DM8VUX3 Investigative 15-deoxy-Delta(12, 14)-prostaglandin J(2) decreases the expression of Vimentin. [74]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Investigative 3,7,3',4'-TETRAHYDROXYFLAVONE decreases the expression of Vimentin. [75]
27-hydroxycholesterol DM2L6OZ Investigative 27-hydroxycholesterol increases the expression of Vimentin. [76]
gingerol DMNXYSM Investigative gingerol decreases the expression of Vimentin. [77]
MANGIFERIN DMWAF5Z Investigative MANGIFERIN decreases the expression of Vimentin. [78]
NMS-873 DMYKZ6U Investigative NMS-873 decreases the expression of Vimentin. [79]
DIECKOL DMBCK4G Investigative DIECKOL decreases the expression of Vimentin. [80]
Bafilomycin A1 DMUNK59 Investigative Bafilomycin A1 increases the expression of Vimentin. [81]
Hydroxyestradiol DMJXQME Investigative Hydroxyestradiol increases the expression of Vimentin. [82]
Tyrphostin Ag-1478 DM87ZIH Investigative Tyrphostin Ag-1478 decreases the expression of Vimentin. [58]
N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE DM2D4KY Investigative N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE decreases the expression of Vimentin. [12]
ROLIPRAM DMJ03UM Investigative ROLIPRAM decreases the expression of Vimentin. [83]
TRISMETHOXYRESVERATROL DM6USPC Investigative TRISMETHOXYRESVERATROL decreases the expression of Vimentin. [85]
schisandrin A DMWQ480 Investigative schisandrin A decreases the expression of Vimentin. [86]
NADA DM3ORGM Investigative NADA decreases the expression of Vimentin. [87]
PI-3065 DMCQUWI Investigative PI-3065 decreases the expression of Vimentin. [88]
J-009747 DMQSB6N Investigative J-009747 increases the expression of Vimentin. [89]
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⏷ Show the Full List of 90 Drug(s)
2 Drug(s) Affected the Protein Interaction/Cellular Processes of This DOT
Drug Name Drug ID Highest Status Interaction REF
Dihydroartemisinin DMBXVMZ Approved Dihydroartemisinin affects the binding of Vimentin. [35]
toxaphene DM4R657 Investigative toxaphene increases the degradation of Vimentin. [84]
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1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the methylation of Vimentin. [52]
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1 Drug(s) Affected the Biochemical Pathways of This DOT
Drug Name Drug ID Highest Status Interaction REF
acrolein DMAMCSR Investigative acrolein increases the metabolism of Vimentin. [68]
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References

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