Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZE2JO)

Drug Name

SNS-595 Drug Info

Synonyms

Voreloxin; Vosaroxin; AG 7352; SNS 595; SPC 595; AG 7352 (TN); AG-7352; SNS 595 (TN); SPC 595 (TN); SPC-595; Voreloxin (TN); Voreloxin (USAN); SNS-595 (TN); 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 3	[1]
Ovarian cancer	2C73	Phase 2	[2]

Cross-matching ID

PubChem CID: 9952884
CAS Number: CAS 175414-77-4
TTD Drug ID: DMZE2JO

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[5]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[6]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[7]
Idarubicin	DMM0XGL	Acute myelogenous leukaemia	2A41	Approved	[5]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[5]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[8]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[5]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[9]
Enoxacin	DMYTE6L	Acute gonococcal cervicitis		Approved	[10]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[12]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[14]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[18]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[23]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[24]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[25]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[30]
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Drug(s) Affected By Isocitrate dehydrogenase , mitochondrial (IDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[36]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[39]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[40]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[43]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[43]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[48]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Gene/Protein Processing	[4]
Isocitrate dehydrogenase , mitochondrial (IDH2)	OTTQA4PB	IDHP_HUMAN	Gene/Protein Processing	[4]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[4]

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References

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