General Information of DTT (ID: TTDP1UC)

DTT Name Fatty acid amide hydrolase (FAAH) DTT Info
Gene Name FAAH

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [1]
Thiopental DMGP8AX Anaesthesia 9A78.6 Approved [2]
------------------------------------------------------------------------------------
5 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
IW-6118 DMP42W1 Inflammation 1A00-CA43.1 Phase 2 [3]
JNJ-42165279 DM72GZO Anxiety disorder 6B00-6B0Z Phase 2 [4]
PF-04457845 DMPRYU1 Liver disease DB90-BD99 Phase 2 [5]
SSR411298 DMGTB2Q Major depressive disorder 6A70.3 Phase 2 [6]
IPI-940 DMEIM5G Pain MG30-MG3Z Phase 1 [7]
------------------------------------------------------------------------------------
72 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aryl urea derivative 1 DM0B9SP N. A. N. A. Patented [8]
Aryl urea derivative 2 DMQWJ12 N. A. N. A. Patented [8]
Aryl urea derivative 3 DM1G7KI N. A. N. A. Patented [8]
Aryl urea derivative 4 DM0HOJW N. A. N. A. Patented [8]
Aryl urea derivative 5 DM54V1R N. A. N. A. Patented [8]
Azetidine urea derivative 1 DMH942E N. A. N. A. Patented [8]
Azetidine urea derivative 2 DMJY8XI N. A. N. A. Patented [8]
Azetidine urea derivative 3 DM48PIO N. A. N. A. Patented [8]
Azole derivative 1 DM76HXA N. A. N. A. Patented [8]
Azole derivative 2 DMOPNJ6 N. A. N. A. Patented [8]
Azole derivative 3 DMN9KTJ N. A. N. A. Patented [8]
Azole derivative 4 DMOW01E N. A. N. A. Patented [8]
Azole derivative 5 DM36QM5 N. A. N. A. Patented [8]
Benzoxazole derivative 1 DMY01FU N. A. N. A. Patented [8]
Benzyl pyrrolyloxoacetamide derivative 1 DMIAB94 N. A. N. A. Patented [8]
Benzyl pyrrolyloxoacetamide derivative 2 DMHOLQF N. A. N. A. Patented [8]
Boronic acid derivative 1 DMMRXEQ N. A. N. A. Patented [8]
Boronic acid derivative 2 DMLJH5T N. A. N. A. Patented [8]
Boronic acid derivative 3 DMQ8X94 N. A. N. A. Patented [8]
Boronic acid derivative 4 DMVIFXR N. A. N. A. Patented [8]
Boronic acid derivative 5 DMUCW9Y N. A. N. A. Patented [8]
Boronic acid derivative 6 DMLMV4O N. A. N. A. Patented [8]
Carbamate derivative 1 DMNDPEA N. A. N. A. Patented [8]
Carbamate derivative 10 DMP98CL N. A. N. A. Patented [9]
Carbamate derivative 16 DMPLZSE N. A. N. A. Patented [9]
Carbamate derivative 17 DMYSRPT N. A. N. A. Patented [9]
Carbamate derivative 3 DMO6NWD N. A. N. A. Patented [8]
Carbamate derivative 7 DMOPF9N N. A. N. A. Patented [8]
Carbamate derivative 8 DMEAO42 N. A. N. A. Patented [8]
Carbamate derivative 9 DMW4B1U N. A. N. A. Patented [9]
Carbamide derivative 1 DMXQTPJ N. A. N. A. Patented [8]
Carbamide derivative 24 DMD6Y73 N. A. N. A. Patented [9]
Carbamide derivative 25 DM8ONCL N. A. N. A. Patented [9]
Carbamide derivative 26 DMDU9XF N. A. N. A. Patented [9]
Enol carbamate derivative 1 DMNBAZH N. A. N. A. Patented [8]
Ethylaminopyrimidine derivative 1 DMTBG39 N. A. N. A. Patented [8]
Heteroaryl-substituted urea derivative 1 DM2BM1L N. A. N. A. Patented [8]
Heteroaryl-substituted urea derivative 2 DMHFQLC N. A. N. A. Patented [8]
Imidazolyl urea derivative 1 DM847I2 N. A. N. A. Patented [8]
Isoxazoline derivative 1 DMLR8MS N. A. N. A. Patented [8]
Isoxazoline derivative 2 DMK5M8Q N. A. N. A. Patented [8]
Isoxazoline derivative 3 DMBVDHK N. A. N. A. Patented [8]
Isoxazoline derivative 4 DM01DG4 N. A. N. A. Patented [8]
Ketoheterocycle derivative 1 DM1ZK7E N. A. N. A. Patented [8]
Ketoheterocycle derivative 2 DM3KW2A N. A. N. A. Patented [8]
Ketoheterocycle derivative 3 DMFHD05 N. A. N. A. Patented [8]
Ketoheterocycle derivative 4 DM2LQXY N. A. N. A. Patented [8]
N-alkyl-4-oxazolecar boxamide derivative 1 DMU2WGL N. A. N. A. Patented [8]
N-alkyl-4-oxazolecar boxamide derivative 2 DMR6YAD N. A. N. A. Patented [8]
Piperazine carbamic compound 1 DMZSYU4 N. A. N. A. Patented [9]
Piperazine carbamic compound 2 DMMQ0ZO N. A. N. A. Patented [9]
Piperazine urea derivative 1 DMEWAQ9 N. A. N. A. Patented [8]
PMID26413912-Compound-84 DMNOJGW N. A. N. A. Patented [8]
PMID29053063-Compound-11d DMDRK68 N. A. N. A. Patented [9]
PMID29053063-Compound-14 DMBR72X N. A. N. A. Patented [9]
PMID29053063-Compound-15 DM07U5R N. A. N. A. Patented [9]
Pyrazole derivative 80 DMQ3TGM N. A. N. A. Patented [9]
Pyrazole derivative 81 DMWT437 N. A. N. A. Patented [9]
Pyrazole derivative 82 DMETCI3 N. A. N. A. Patented [9]
Pyrazole derivative 83 DMMGLOA N. A. N. A. Patented [9]
Pyrazole derivative 84 DME8Q0F N. A. N. A. Patented [9]
Pyrimidinyl ethylenediamine derivative 1 DMZ83P1 N. A. N. A. Patented [8]
Pyrrolidinyl urea derivative 1 DM7DF6Z N. A. N. A. Patented [8]
Spirocyclic diamine urea derivative 1 DM4R7OQ N. A. N. A. Patented [8]
Spirocyclic diamine urea derivative 2 DMH5N78 N. A. N. A. Patented [8]
Tetra-hydro-naphthalene derivative 1 DMURYO0 N. A. N. A. Patented [8]
Tetra-hydro-naphthalene derivative 2 DMEBGZJ N. A. N. A. Patented [8]
Tetra-hydro-naphthalene derivative 3 DMVBZKF N. A. N. A. Patented [8]
Tetra-hydro-naphthyridine derivative 1 DM5YSTU N. A. N. A. Patented [8]
Tetra-substituted urea derivative 1 DMEG5YO N. A. N. A. Patented [8]
Tetra-substituted urea derivative 2 DMKXZUA N. A. N. A. Patented [8]
Tetrazolyl urea derivative 1 DM2D4WQ N. A. N. A. Patented [8]
------------------------------------------------------------------------------------
⏷ Show the Full List of 72 Patented Agent(s)
220 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+/-)-3-(but-3-enyl)-1-pent-4-enoylazetidin-2-one DM9AJSU Discovery agent N.A. Investigative [10]
(+/-)-3-(pent-4-enyl)azetidin-2-one DMWIABE Discovery agent N.A. Investigative [10]
(+/-)-3-allyl-1-pent-4-enoylazetidin-2-one DMS5AWP Discovery agent N.A. Investigative [10]
(+/-)-3-allylazetidin-2-one DMK42RU Discovery agent N.A. Investigative [10]
(+/-)-oxiran-2-ylmethyl (9Z)-hexadec-9-enoate DM8023E Discovery agent N.A. Investigative [11]
(+/-)-oxiran-2-ylmethyl (9Z)-octadec-9-enoate DMI5R3E Discovery agent N.A. Investigative [11]
(Z)-1,1,1-Trifluoro-nonadec-10-en-2-one DMBTMDG Discovery agent N.A. Investigative [12]
(Z)-1-(4-phenyloxazol-2-yl)octadec-9-en-1-one DMVZYNH Discovery agent N.A. Investigative [13]
(Z)-1-(benzo[d]oxazol-2-yl)octadec-9-en-1-one DMNBDGH Discovery agent N.A. Investigative [13]
(Z)-1-(pyridazin-3-yl)octadec-9-en-1-one DMMTXKO Discovery agent N.A. Investigative [13]
(Z)-2,2-Dimethyl-1-oxazol-2-yl-octadec-9-en-1-one DM2HZX8 Discovery agent N.A. Investigative [14]
(Z)-2-Methyl-1-oxazol-2-yl-octadec-9-en-1-one DMYH9BC Discovery agent N.A. Investigative [14]
1,1,1-trifluoro-3-(hexylthio)propan-2-one DMWGSP6 Discovery agent N.A. Investigative [15]
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one DMLBT0E Discovery agent N.A. Investigative [15]
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one DMT29SN Discovery agent N.A. Investigative [15]
1,1,1-trifluoro-3-(octylthio)propan-2-one DMU4EJW Discovery agent N.A. Investigative [15]
1,1,1-Trifluoro-7-phenylheptan-2-one DMLHVWP Discovery agent N.A. Investigative [12]
1,1,1-Trifluoro-8-phenyl-octan-2-one DMYENI7 Discovery agent N.A. Investigative [12]
1,1,1-Trifluoro-9-phenyl-nonan-2-one DM7DWVL Discovery agent N.A. Investigative [12]
1,1,1-Trifluoro-nonadecan-2-one DM8TWY7 Discovery agent N.A. Investigative [12]
1,1,1-Trifluoro-tridecan-2-one DM4CEQP Discovery agent N.A. Investigative [12]
1,1,1-Trifluoro-undecan-2-one DMX2SFW Discovery agent N.A. Investigative [12]
1,1,1-trifluorododecan-2-one DMW6CQV Discovery agent N.A. Investigative [15]
1,10-(methylenedi-4,1-phenylene)bismaleimide DMYVBD2 Discovery agent N.A. Investigative [16]
1,4-bis(malimido)xylene DMC4LMT Discovery agent N.A. Investigative [16]
1,8-bis-maleimidodiethyleneglycol DMKJGTH Discovery agent N.A. Investigative [16]
1-(1,2,4-Oxadiazol-3-yl)-7-phenylheptan-1-one DMPMLZF Discovery agent N.A. Investigative [17]
1-(1,2,4-Oxadiazol-5-yl)-7-phenylheptan-1-one DMBS90M Discovery agent N.A. Investigative [17]
1-(1,3,4-Oxadiazol-2-yl)-7-phenylheptan-1-one DMHIYB3 Discovery agent N.A. Investigative [17]
1-(1,3,4-oxadiazol-2-yl)octadec-9-en-1-one DMZ1GH0 Discovery agent N.A. Investigative [17]
1-(1,3,4-thiadiazol-2-yl)octadec-9-en-1-one DM6B14Q Discovery agent N.A. Investigative [17]
1-(4-acetyloxazol-2-yl)-7-phenylheptan-1-one DM170BV Discovery agent N.A. Investigative [18]
1-(4-bromooxazol-2-yl)-7-phenylheptan-1-one DMUMNYZ Discovery agent N.A. Investigative [18]
1-(4-chlorooxazol-2-yl)-7-phenylheptan-1-one DMXGB38 Discovery agent N.A. Investigative [18]
1-(4-iodooxazol-2-yl)-7-phenylheptan-1-one DMDY93H Discovery agent N.A. Investigative [18]
1-(4-methoxyoxazol-2-yl)-7-phenylheptan-1-one DMEPJRD Discovery agent N.A. Investigative [18]
1-(4-methyloxazol-2-yl)-7-phenylheptan-1-one DMVI2PM Discovery agent N.A. Investigative [18]
1-(5-(furan-2-yl)oxazol-2-yl)octadec-9-en-1-one DMPL3UZ Discovery agent N.A. Investigative [17]
1-(5-(pyridin-2-yl)oxazol-2-yl)dodecan-1-one DM4V9IB Discovery agent N.A. Investigative [13]
1-(5-(pyridin-2-yl)oxazol-2-yl)octadec-9-en-1-one DMICZK0 Discovery agent N.A. Investigative [17]
1-(5-(pyridin-2-yl)oxazol-2-yl)octan-1-one DMZNEIB Discovery agent N.A. Investigative [13]
1-(5-(pyridin-2-yl)oxazol-2-yl)pentan-1-one DM6FDAY Discovery agent N.A. Investigative [13]
1-(5-fluorooxazol-2-yl)-7-phenylheptan-1-one DMD8IYZ Discovery agent N.A. Investigative [13]
1-(5-methyloxazol-2-yl)-7-phenylheptan-1-one DMWQ9ZP Discovery agent N.A. Investigative [13]
1-(5-phenyloxazol-2-yl)octadec-9-en-1-one DMRITHA Discovery agent N.A. Investigative [17]
1-(5-Pyridin-2-yl-oxazol-2-yl)-octadec-9-yn-1-one DM4IMON Discovery agent N.A. Investigative [12]
1-(oxazol-2-yl)-3-(4-phenoxyphenyl)propan-1-one DMXT2ZL Discovery agent N.A. Investigative [19]
1-(oxazol-2-yl)-4-(piperidin-4-yl)butan-1-one DMEOS8P Discovery agent N.A. Investigative [20]
1-(oxazol-2-yl)-7-phenylheptan-1-one DMLKA5O Discovery agent N.A. Investigative [18]
1-(oxazol-2-yl)octadec-9-en-1-one DM1ATS3 Discovery agent N.A. Investigative [17]
1-(oxazolo[4,5-b]pyridin-2-yl)dodecan-1-one DMT7P2Z Discovery agent N.A. Investigative [13]
1-(oxazolo[4,5-b]pyridin-2-yl)octan-1-one DMFGUXZ Discovery agent N.A. Investigative [13]
1-(oxazolo[4,5-b]pyridin-2-yl)pentan-1-one DMH2G13 Discovery agent N.A. Investigative [13]
1-Benzooxazol-2-yl-6-phenyl-hexan-1-one DM153Y8 Discovery agent N.A. Investigative [12]
1-Biphenyl-4-ylmaleimide DM9QTWB Discovery agent N.A. Investigative [16]
1-Biphenyl-4-ylmethylmaleimide DMKL201 Discovery agent N.A. Investigative [16]
1-DODECANOL DM7P3N5 Discovery agent N.A. Investigative [21]
1-Imidazol-1-yl-3-(4-octylphenoxy)propan-2-one DM3JHVL Discovery agent N.A. Investigative [22]
1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-hexan-1-one DMPMGLO Discovery agent N.A. Investigative [23]
1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-yn-1-one DM9BY8D Discovery agent N.A. Investigative [12]
2,2-dimethyl-3-methyleneheptadecane DM7BL04 Discovery agent N.A. Investigative [15]
2,4-difluorophenyl 4-butoxybenzylcarbamate DM75TJ1 Discovery agent N.A. Investigative [24]
2-(7-phenylheptanoyl)oxazole-4-carbaldehyde DMJAEZ8 Discovery agent N.A. Investigative [18]
2-(7-phenylheptanoyl)oxazole-4-carbonitrile DMVSL49 Discovery agent N.A. Investigative [18]
2-(7-phenylheptanoyl)oxazole-4-carboxamide DM9JMF2 Discovery agent N.A. Investigative [18]
2-(7-phenylheptanoyl)oxazole-4-carboxylic acid DM9BE2S Discovery agent N.A. Investigative [18]
2-(7-phenylheptanoyl)oxazole-5-carbonitrile DM89RYN Discovery agent N.A. Investigative [18]
2-(7-phenylheptanoyl)oxazole-5-carboxylic acid DMB53ML Discovery agent N.A. Investigative [18]
2-(biphenyl-4-yl)vinylboronic acid DMRQOKB Discovery agent N.A. Investigative [25]
2-arachidonoylglycerol DMM0KOJ Discovery agent N.A. Investigative [26]
2-chloro-1-(5-(pyridin-2-yl)oxazol-2-yl)ethanone DMG5SAQ Discovery agent N.A. Investigative [27]
2-Cyclohexylacetic acidbiphenyl-3-yl ester DMS1T0V Discovery agent N.A. Investigative [28]
2-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate DM5OW91 Discovery agent N.A. Investigative [24]
2-fluorophenyl 4'-ethylbiphenyl-4-ylcarbamate DMGIKWA Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-(decyloxy)phenylcarbamate DMSFQAZ Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-(dodecyloxy)phenylcarbamate DMCEGZU Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-(heptyloxy)phenylcarbamate DMLM2WU Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-(hexyloxy)phenylcarbamate DM854ED Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-(octyloxy)phenylcarbamate DM81J0O Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-(undecyloxy)phenylcarbamate DMTYX5G Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-butoxybenzylcarbamate DM4EIQ3 Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-butoxyphenylcarbamate DMYJ1M4 Discovery agent N.A. Investigative [24]
2-fluorophenyl 4-phenoxyphenylcarbamate DMSMDQC Discovery agent N.A. Investigative [24]
2-fluorophenylboronic acid DMXPFYZ Discovery agent N.A. Investigative [25]
2-methoxyphenylboronic acid DML5PE9 Discovery agent N.A. Investigative [25]
3'-carbamoylbiphenyl-3-yl 6-phenylhexylcarbamate DM530OW Discovery agent N.A. Investigative [29]
3,3-di(pent-4-enyl)azetidin-2-one DMK9BN0 Discovery agent N.A. Investigative [10]
3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate DMONSM1 Discovery agent N.A. Investigative [30]
3-(benzo[d]oxazol-2-yl)phenyl propylcarbamate DMPFH8U Discovery agent N.A. Investigative [30]
3-(biphenyl-4-yl)-1-(oxazol-2-yl)propan-1-one DM4GWJO Discovery agent N.A. Investigative [19]
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one DMWJ6UD Discovery agent N.A. Investigative [15]
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one DMF27YT Discovery agent N.A. Investigative [15]
3-(decylthio)-1,1,1-trifluoropropan-2-one DM1Y6L8 Discovery agent N.A. Investigative [15]
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one DM7AG6Y Discovery agent N.A. Investigative [15]
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one DMPRCS0 Discovery agent N.A. Investigative [15]
3-(ethoxycarbonyl)phenylboronic acid DM71EMN Discovery agent N.A. Investigative [25]
3-(trifluoromethyl)phenyl 4-butoxybenzylcarbamate DMH7K0N Discovery agent N.A. Investigative [24]
3-(trifluoromethyl)phenylboronic acid DM4B5JY Discovery agent N.A. Investigative [25]
3-chlorophenyl 4-butoxybenzylcarbamate DMJ2SZ1 Discovery agent N.A. Investigative [24]
3-cyanophenylboronic acid DMPWR90 Discovery agent N.A. Investigative [25]
3-methoxyphenylboronic acid DMHJTLW Discovery agent N.A. Investigative [25]
4-(1,2,3-thiadiazol-4-yl)phenyl butylcarbamate DMG4HO3 Discovery agent N.A. Investigative [31]
4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate DMSFGRI Discovery agent N.A. Investigative [31]
4-(4,5-dihydrothiazol-2-yl)phenyl butylcarbamate DMOF0J1 Discovery agent N.A. Investigative [31]
4-(cyclohexylmethylcarbamoyloxy)benzoic acid DMWYESB Discovery agent N.A. Investigative [29]
4-(thiazol-2-yl)phenyl butylcarbamate DMSUM3C Discovery agent N.A. Investigative [32]
4-(trifluoromethyl)phenylboronic acid DMADZQ9 Discovery agent N.A. Investigative [25]
4-cyanophenyl ethyl dodecylphosphonate DMEP80Q Discovery agent N.A. Investigative [33]
4-cyanophenylboronic acid DMOLFHZ Discovery agent N.A. Investigative [25]
4-fluorophenyl 1-(4-butoxyphenyl)propylcarbamate DMZV3MD Discovery agent N.A. Investigative [24]
4-fluorophenyl 4-butoxybenzylcarbamate DMCRJ54 Discovery agent N.A. Investigative [24]
4-fluorophenylboronic acid DMD5LXQ Discovery agent N.A. Investigative [25]
4-methoxyphenyl 1-(4-butoxyphenyl)propylcarbamate DM739SQ Discovery agent N.A. Investigative [24]
4-methoxyphenylboronic acid DMP5YFQ Discovery agent N.A. Investigative [25]
4-Nitrophenyl 4-Benzylpiperazine-1-carboxylate DMTJ3F9 Discovery agent N.A. Investigative [34]
4-nitrophenylboronic acid DMO6XK2 Discovery agent N.A. Investigative [25]
4-nonylphenylboronic acid DMBF5KW Discovery agent N.A. Investigative [25]
4-Phenylbutylcarbamic Acid Biphenyl-3-yl Ester DM871ZE Discovery agent N.A. Investigative [28]
6-fluoropyridin-3-ylboronic acid DMS325C Discovery agent N.A. Investigative [25]
6-Phenylhexylcarbamic Acid Biphenyl-3-yl Ester DMLJN8Z Discovery agent N.A. Investigative [28]
7-Phenyl-1-(1,3,4-thiadiazol-2-yl)-heptan-1-one DMQMRGD Discovery agent N.A. Investigative [17]
7-Phenyl-1-(2H-tetrazol-5-yl)-heptan-1-one DMEABGI Discovery agent N.A. Investigative [17]
7-phenyl-1-(4-phenyloxazol-2-yl)heptan-1-one DM62PAU Discovery agent N.A. Investigative [18]
7-phenyl-1-(5-phenyloxazol-2-yl)heptan-1-one DM9SGBW Discovery agent N.A. Investigative [17]
7-Phenyl-1-(pyridazin-3-yl)-heptan-1-one DMG1PNX Discovery agent N.A. Investigative [17]
7-Phenyl-1-(thiazol-2-yl)-heptan-1-one DMLHI5T Discovery agent N.A. Investigative [17]
8-Phenyloctylcarbamic Acid Biphenyl-3-yl Ester DM4TWRJ Discovery agent N.A. Investigative [28]
Adamant-1-ylcarbamic Acid Biphenyl-3-yl Ester DMKDRVZ Discovery agent N.A. Investigative [28]
Allylcarbamic Acid Biphenyl-3-yl Ester DMJWZB3 Discovery agent N.A. Investigative [28]
AM-404 DMBK9PS Discovery agent N.A. Investigative [35]
AR-C70484XX DMU3A57 Discovery agent N.A. Investigative [22]
ARACHIDONYL TRIFLUOROMETHYLKETONE DMHL48F Discovery agent N.A. Investigative [22]
Benzaldehyde O-4-(decyloxy)phenylcarbamoyl oxime DMFPSOQ Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-(heptyloxy)phenylcarbamoyl oxime DMU7INH Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-(hexyloxy)phenylcarbamoyl oxime DMOK0U8 Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-(nonyloxy)phenylcarbamoyl oxime DMIV3S8 Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-(octyloxy)phenylcarbamoyl oxime DMBW7PX Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-(pentyloxy)phenylcarbamoyl oxime DMWEXOY Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-butoxyphenylcarbamoyl oxime DMHUQWN Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-ethoxyphenylcarbamoyl oxime DMD98YP Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-methoxyphenylcarbamoyl oxime DMLHKQS Discovery agent N.A. Investigative [24]
Benzaldehyde O-4-propoxyphenylcarbamoyl oxime DMARBF9 Discovery agent N.A. Investigative [24]
Benzofuran-2-ylboronic acid DMQ7I06 Discovery agent N.A. Investigative [25]
Benzo[b]thiophen-2-ylboronic acid DMJQSLW Discovery agent N.A. Investigative [25]
Benzylcarbamic Acid Biphenyl-3-yl Ester DM7M9O2 Discovery agent N.A. Investigative [28]
Biphenyl-3-ylboronic acid DMIAUB1 Discovery agent N.A. Investigative [25]
Biphenyl-3-ylcarbamic Acid Biphenyl-3-yl Ester DMYCKGH Discovery agent N.A. Investigative [28]
Biphenyl-3-ylcarbamic acid cyclohexyl ester DM10AUP Discovery agent N.A. Investigative [16]
Biphenyl-4-ylboronic acid DMIHMP5 Discovery agent N.A. Investigative [25]
BMS-1 DM4D6ZB Discovery agent N.A. Investigative [36]
bromoenol lactone DMKQ0CA Discovery agent N.A. Investigative [29]
Chlorphrifos oxon DMGBT68 Discovery agent N.A. Investigative [37]
Cyclobutylcarbamic Acid Biphenyl-3-yl Ester DMYLA7F Discovery agent N.A. Investigative [28]
Cyclohexyl biphenyl-4-ylcarbamate DMZKH4R Discovery agent N.A. Investigative [31]
Cyclohexylcarbamic acidbiphenyl-3-yl ester DM06OLY Discovery agent N.A. Investigative [28]
Cyclohexylmethylcarbamic Acid Biphenyl-3-yl Ester DMEW7AY Discovery agent N.A. Investigative [28]
Cyclopentyl(5-(pyridin-2-yl)oxazol-2-yl)methanone DM0J9I5 Discovery agent N.A. Investigative [27]
Cyclopentylcarbamic Acid Biphenyl-3-yl Ester DMQLGFH Discovery agent N.A. Investigative [28]
Dodecane-1-sulfonyl fluoride DME9CGK Discovery agent N.A. Investigative [33]
Ethyl octylfluorophosphonate DMXMRK7 Discovery agent N.A. Investigative [37]
Furan-2-ylmethylcarbamic Acid Biphenyl-3-yl Ester DM9XPUN Discovery agent N.A. Investigative [28]
HTS-00798 DMXV379 Discovery agent N.A. Investigative [32]
Indan-2-ylcarbamic Acid Biphenyl-3-yl Ester DMVZMBU Discovery agent N.A. Investigative [28]
Isopropyl 4-nitrophenyl dodecylphosphonate DM2VJF4 Discovery agent N.A. Investigative [33]
Isopropyl dodecylfluorophosphonate DML54EA Discovery agent N.A. Investigative [37]
Isopropylcarbamic Acid Biphenyl-3-yl Ester DMBR8P1 Discovery agent N.A. Investigative [28]
JNJ-1661010 DM3ZNF9 Discovery agent N.A. Investigative [38]
LY-2183240 DM8SU6N Discovery agent N.A. Investigative [29]
LY-2318912 DMPV6N9 Discovery agent N.A. Investigative [39]
Methoxy arachidonyl fluorophosphonate DMX8QK0 Discovery agent N.A. Investigative [40]
Methyl 2-(7-phenylheptanoyl)oxazole-4-carboxylate DMP06I3 Discovery agent N.A. Investigative [18]
Methyl 2-(7-phenylheptanoyl)oxazole-5-carboxylate DM9FA26 Discovery agent N.A. Investigative [17]
Methyl icosylphosphonofluoridate DM9O5S6 Discovery agent N.A. Investigative [33]
Methylcarbamic Acid Biphenyl-3-yl Ester DMDP84X Discovery agent N.A. Investigative [28]
N-(2-hydroxyethyl)linoleoylamide DM97MGE Discovery agent N.A. Investigative [41]
N-(2-iodethyl)arachidonylamide DM8ORQ4 Discovery agent N.A. Investigative [41]
N-(2-iodoethyl)linoleoylamide DMV84PQ Discovery agent N.A. Investigative [41]
N-(4-hydroxybenzyl)icosa-5,8,11,14-tetraenamide DM7O5WS Discovery agent N.A. Investigative [35]
N-arachidonylmaleimide DMLVGT8 Discovery agent N.A. Investigative [16]
N-Butylcarbamic Acid Biphenyl-3-yl Ester DMW7BZT Discovery agent N.A. Investigative [28]
N-Hexylcarbamic Acid Biphenyl-3-yl Ester DML27CG Discovery agent N.A. Investigative [28]
N-Octylcarbamic Acid Biphenyl-3-yl Ester DM95JEW Discovery agent N.A. Investigative [28]
Naphthalen-2-yl cyclohexylcarbamate DMDXM2A Discovery agent N.A. Investigative [29]
NICARBAZIN DM4I6MD Discovery agent N.A. Investigative [42]
Nicotinaldehyde O-4-butoxyphenylcarbamoyl oxime DM0DFNJ Discovery agent N.A. Investigative [24]
Nicotinaldehyde O-4-ethoxyphenylcarbamoyl oxime DM957CK Discovery agent N.A. Investigative [24]
Nicotinaldehyde O-4-propoxyphenylcarbamoyl oxime DMC9WAL Discovery agent N.A. Investigative [24]
Octane-1-sulfonyl fluoride DMDBI5S Discovery agent N.A. Investigative [33]
OL-135 DMT1CZ0 Pain MG30-MG3Z Investigative [43]
OL-92 DM5ZJ3G Discovery agent N.A. Investigative [36]
Org-231295 DMTFGYH Anxiety disorder 6B00-6B0Z Investigative [7]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [37]
PF3845 DMCRXAM Discovery agent N.A. Investigative [44]
PF750 DMBE24Y Discovery agent N.A. Investigative [45]
Phenethylboronic acid DMPDVG2 Discovery agent N.A. Investigative [25]
Phenethylcarbamic Acid Biphenyl-3-yl Ester DM02PAW Discovery agent N.A. Investigative [28]
PHENMEDIPHAM DMYCHTD Discovery agent N.A. Investigative [42]
Phenyl 1-(4-butoxyphenyl)propylcarbamate DMSNIBO Discovery agent N.A. Investigative [24]
Phenyl 4-(decyloxy)phenylcarbamate DMZ03DT Discovery agent N.A. Investigative [24]
Phenyl 4-(dodecyloxy)phenylcarbamate DMR1MQE Discovery agent N.A. Investigative [24]
Phenyl 4-(heptyloxy)phenylcarbamate DM9UNLH Discovery agent N.A. Investigative [24]
Phenyl 4-(hexyloxy)phenylcarbamate DMZ07H6 Discovery agent N.A. Investigative [24]
Phenyl 4-(octyloxy)phenylcarbamate DMULMWK Discovery agent N.A. Investigative [24]
Phenyl 4-(undecyloxy)phenylcarbamate DMSZ2CO Discovery agent N.A. Investigative [24]
Phenyl Boronic acid DMFZH49 Discovery agent N.A. Investigative [25]
Phenyl-1,4-bismaleimide DMWEKBD Discovery agent N.A. Investigative [16]
Phenylcarbamic Acid Biphenyl-3-yl Ester DMMNYXK Discovery agent N.A. Investigative [28]
Propan-2-one O-3-butoxyphenylcarbamoyl oxime DMQZYW6 Discovery agent N.A. Investigative [24]
Propan-2-one O-4-(decyloxy)phenylcarbamoyl oxime DMIQ0DF Discovery agent N.A. Investigative [24]
Propan-2-one O-4-(heptyloxy)phenylcarbamoyl oxime DM8FXM6 Discovery agent N.A. Investigative [24]
Propan-2-one O-4-(hexyloxy)phenylcarbamoyl oxime DM5J0H3 Discovery agent N.A. Investigative [24]
Propan-2-one O-4-(nonyloxy)phenylcarbamoyl oxime DMYBH91 Discovery agent N.A. Investigative [24]
Propan-2-one O-4-(octyloxy)phenylcarbamoyl oxime DM6VZ4S Discovery agent N.A. Investigative [24]
Propan-2-one O-4-(pentyloxy)phenylcarbamoyl oxime DM408U3 Discovery agent N.A. Investigative [24]
Propan-2-one O-4-butoxybenzylcarbamoyl oxime DMV13MO Discovery agent N.A. Investigative [24]
Propan-2-one O-4-butoxyphenylcarbamoyl oxime DMYJ28G Discovery agent N.A. Investigative [24]
Propan-2-one O-4-ethoxyphenylcarbamoyl oxime DM573UT Discovery agent N.A. Investigative [24]
Propan-2-one O-4-propoxyphenylcarbamoyl oxime DMWX5Q6 Discovery agent N.A. Investigative [24]
Pyridin-3-yl 4-butoxybenzylcarbamate DMOCG6M Discovery agent N.A. Investigative [24]
VER-156084 DMFZMA2 Neuropathic pain 8E43.0 Investigative [46]
------------------------------------------------------------------------------------
⏷ Show the Full List of 220 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
2 The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase. Br J Pharmacol. 2003 Jul;139(5):1005-13.
3 The Discovery and Development of Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Bioorg Med Chem Lett. 2011 August 15; 21(16): 4674-4685.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor. ACS Med Chem Lett. 2011 Feb 10;2(2):91-96.
6 Pharma & Vaccines. Product Development Pipeline. April 29 2009.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1400).
8 Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66.
9 A patent review of Monoacylglycerol Lipase (MAGL) inhibitors (2013-2017).Expert Opin Ther Pat. 2017 Dec;27(12):1341-1351.
10 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4163-7.
11 Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase. J Med Chem. 2007 Oct 4;50(20):5012-23.
12 Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as a... J Med Chem. 2005 Mar 24;48(6):1849-56.
13 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95.
14 alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1517-20.
15 Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hy... Bioorg Med Chem. 2008 Feb 15;16(4):2114-30.
16 Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. J Med Chem. 2009 Dec 10;52(23):7410-20.
17 Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Aug 14;51(15):4392-403.
18 Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hyd... Bioorg Med Chem Lett. 2008 Nov 15;18(22):5842-6.
19 Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Feb 28;51(4):937-47.
20 Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH). Bioorg Med Chem Lett. 2008 Mar 15;18(6):2109-13.
21 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
22 1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase. Bioorg Med Chem. 2010 Jan 15;18(2):945-52.
23 The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem. 2005 Aug 11;48(16):5059-87.
24 Oxime carbamate--discovery of a series of novel FAAH inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1272-7.
25 Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem. 2008 Nov 27;51(22):7057-60.
26 Conformationally constrained analogues of 2-arachidonoylglycerol. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5959-63.
27 Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem. 2007 Jul 12;50(14):3359-68.
28 Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl a... J Med Chem. 2008 Jun 26;51(12):3487-98.
29 Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43.
30 Chiral 3-(4,5-dihydrooxazol-2-yl)phenyl alkylcarbamates as novel FAAH inhibitors: Insight into FAAH enantioselectivity by molecular docking and int... Eur J Med Chem. 2009 Oct;44(10):4179-91.
31 The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem. 2009 Jul;44(7):2994-3008.
32 Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system. J Med Chem. 2006 Jul 27;49(15):4650-6.
33 Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels. Bioorg Med Chem Lett. 2008 Nov 15;18(22):5875-8.
34 Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases. J Med Chem. 2010 Feb 25;53(4):1830-42.
35 New analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide. J Med Chem. 2008 Dec 25;51(24):7800-5.
36 Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors. J Med Chem. 2009 Jan 8;52(1):170-80.
37 Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol. 2008 Jun;4(6):373-8.
38 Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.
39 Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation. Eur J Med Chem. 2008 Jan;43(1):62-72.
40 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
41 Radiosynthesis, in vitro and in vivo evaluation of 123I-labeled anandamide analogues for mapping brain FAAH. Bioorg Med Chem. 2009 Jan 1;17(1):49-56.
42 Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inh... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6793-6.
43 X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J Med Chem. 2010 Jan 14;53(1):230-40.
44 Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24;16(4):411-20.
45 Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30.
46 Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4.