Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM25FL8)

Drug Name
Methimazole Drug Info
Synonyms
methimazole; 60-56-0; thiamazole; Tapazole; 2-Mercapto-1-methylimidazole; Mercazolyl; 1-Methylimidazole-2-thiol; Thymidazole; Mercazole; Methimazol; Thymidazol; Thiamazol; Metazolo; Thycapzol; Metothyrine; Metothyrin; Merkazolil; Mercaptazole; Strumazol; Favistan; Basolan; Thycapsol; Metotirin; Danantizol; Thacapzol; Merkastan; Frentirox; Metizol; Tiamazol; Mercasolyl; 1-Methyl-1H-imidazole-2-thiol; Methylmercaptoimidazole; 1-Methyl-2-mercaptoimidazole; Methiamazole; Usaf el-30; Methimazolum; Mercazolylum; Tapuzole; Metimazol; Thimazole; Basolan; MMZ; Mercazol; Methamazole; Methizol; Methymazol; Metisol; Strumazole; Thiamazole; Thiamazolum; Thimazol; Thyrozol; Tiamazolo; Tirodril; EliLilly Brand of Methimazole; Estedi Brand of Methimazole; Henning Berlin Brand of Methimazole; Hexal Brand of Methimazole; Jones Brand of Methimazole; Merck Brand of Methimazole; Nourypharma Brand of Methimazole; Philopharm Brand of Methimazole; Sanofi Synthelabo Brand of Methimazole; Temmler Brand of Methimazole; Thiamazol Henning; Thiamazol Hexal; Tiamazolo [DCIT]; M0868; Henning, Thiamazol; Hexal, Thiamazol; Methimazole (USP); Methimazole [USAN:BAN]; Tapazole (TN); Thiamazol [INN-French]; Thiamazolum [INN-Latin]; Tiamazol [INN-Spanish]; Mestinon, Regonol, Pyridostigmine Bromide;Thiamazole (JP15/INN); N-Methyl-2-mercaptoimidazole; 1 Methyl 2 mercaptoimidazole; 1,3-Dihydro-1-Methyl-2H-Imidazol-2-Thione; 1,3-Dihydro-1-methyl-2H-imidazole-2-thione; 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE; 1-Methyl-1,3-dihydroimidazole-2-thione; 1-Methyl-2-Imidazolethione; 1-Methyl-2-imidazolethiol; 1-Methyl-imidazole-2-thiol; 1-Methylimidazole-2(3H)-thione; 1-Metylo 2 merkaptoimidazolem; 1-Metylo 2 merkaptoimidazolem [Polish]; 2-Mercaptomethylimidazole; 3-methyl-1H-imidazole-2-thione
Indication
Disease Entry ICD 11 Status REF
Hyperthyroidism 5A02 Approved [1]
Therapeutic Class
Antithyroid Agents
Cross-matching ID
PubChem CID
1349907
ChEBI ID
CHEMBL1515
CAS Number
CAS 60-56-0
TTD Drug ID
DM25FL8
VARIDT Drug ID
DR00667
ACDINA Drug ID
D00410

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Thyroid peroxidase (TPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [10]
Carbimazole DMULAI4 Hyperthyroidism 5A02 Approved [2]
TPO gene plasmid DMFL5XU Thrombocytopenia 3B64 Investigative [11]
Drug(s) Metabolized By Dimethylaniline oxidase 2 (FMO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [12]
Trifluoperazine DMKBYWI Anxiety Approved [12]
Ethionamide DM8K3EI Pulmonary tuberculosis 1B10.Z Approved [3]
Drug(s) Affected By T-box transcription factor TBX3 (TBX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [14]
Quercetin DM3NC4M Obesity 5B81 Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [16]
Panobinostat DM58WKG Chronic graft versus host disease Approved [17]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [6]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [20]
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Drug(s) Affected By Trans-Golgi network integral membrane protein 2 (TGOLN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [24]
Testosterone enanthate DMB6871 N. A. N. A. Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [6]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [27]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [20]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [28]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [29]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [29]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [30]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [28]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [29]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [28]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [32]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [28]
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Drug(s) Affected By Thyrotropin subunit beta (TSHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Octreotide DMHIDCJ Acromegaly 5A60.0 Approved [34]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [35]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [36]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [37]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [38]
NITRATE DMVFB93 Discovery agent N.A. Investigative [39]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [40]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [41]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [42]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [43]
Diazepam DM08E9O Alcohol withdrawal Approved [44]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [45]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [46]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [50]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [51]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [54]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [55]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [56]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [57]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [60]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [61]
Gefitinib DM15F0X Colon adenocarcinoma Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [64]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [69]
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Drug(s) Affected By Integrin beta-5 (ITGB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [6]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [72]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [73]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [6]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [20]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [74]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [76]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [80]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [81]
Gefitinib DM15F0X Colon adenocarcinoma Approved [82]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [84]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [85]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [76]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [86]
Paclitaxel DMLB81S Breast carcinoma Approved [87]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [88]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [75]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [79]
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Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [15]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [93]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [94]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [93]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [95]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [96]
Oxytetracycline DMOVH1M Actinomycosis Approved [97]
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Drug(s) Affected By Low-density lipoprotein receptor-related protein 2 (LRP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Panobinostat DM58WKG Chronic graft versus host disease Approved [71]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [71]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [92]
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Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [54]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [15]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [105]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [106]
Estrone DM5T6US Acne vulgaris ED80 Approved [102]
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Drug(s) Affected By Krueppel-like factor 9 (KLF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Selenium DM25CGV N. A. N. A. Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [110]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [6]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [6]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [111]
Leflunomide DMR8ONJ Arthritis FA20 Approved [18]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
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Drug(s) Affected By Consortin (CNST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [112]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [20]
Arsenic DMTL2Y1 N. A. N. A. Approved [113]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [6]
Urethane DM7NSI0 N. A. N. A. Phase 4 [114]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [117]
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Drug(s) Affected By PTB domain-containing engulfment adapter protein 1 (GULP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [118]
Selenium DM25CGV N. A. N. A. Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [6]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [120]
Ethanol DMDRQZU Chronic pain MG30 Approved [121]
Folic Acid DMEMBJC Colorectal carcinoma Approved [122]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [112]
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Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [112]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [123]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [124]
Almogran DM7I64Z Migraine 8A80 Approved [125]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [126]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [127]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [128]
Clozapine DMFC71L Schizophrenia 6A20 Approved [129]
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Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [130]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [131]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [133]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [134]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [132]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [135]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [136]
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Drug(s) Affected By Flavin-containing monooxygenase 2 (FMO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [12]
Trifluoperazine DMKBYWI Anxiety Approved [12]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Testosterone enanthate DMB6871 N. A. N. A. Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [138]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [128]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [116]
PMID28454500-Compound-96 DM2A75P N. A. N. A. Patented [12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Thyroid peroxidase (TPO) TT52XDZ PERT_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Dimethylaniline oxidase 2 (FMO2) Main DME DEIASEZ FMO2_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Gene/Protein Processing [4]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [6]
Consortin (CNST) OTOUCB98 CNST_HUMAN Gene/Protein Processing [6]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Gene/Protein Processing [6]
Flavin-containing monooxygenase 1 (FMO1) OTTHSQKP FMO1_HUMAN Biotransformations [7]
Flavin-containing monooxygenase 2 (FMO2) OTUJUL9S FMO2_HUMAN Biotransformations [8]
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Regulation of Drug Effects [9]
Integrin beta-5 (ITGB5) OT21MF51 ITB5_HUMAN Gene/Protein Processing [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6649).
2 Diagnosis and treatment of thyrotoxicosis in childhood. A European questionnaire study. Eur J Endocrinol. 1994 Nov;131(5):467-73.
3 Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):167-181.
4 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
5 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
6 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
7 Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Toxicol Sci. 2004 Apr;78(2):196-203.
8 Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenet Genomics. 2005 Apr;15(4):245-56. doi: 10.1097/01213011-200504000-00008.
9 Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. J Pharmacol Exp Ther. 2007 Jan;320(1):266-73. doi: 10.1124/jpet.106.112268. Epub 2006 Oct 18.
10 Bioinorganic chemistry in thyroid gland: effect of antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions. Bioinorg Chem Appl. 2006:23214.
11 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2526).
12 Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Microb Cell Fact. 2015 Jun 12;14:82.
13 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
14 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
15 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
16 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
17 The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
18 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
19 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
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