Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3KJBC)

Drug Name
Epinephrine Drug Info
Synonyms
ADROP; Adnephrine; Adrenal; Adrenalin; Adrenalina; Adrenaline; Adrenalinum; Adrenamine; Adrenan; Adrenapax; Adrenasol; Adrenatrate; Adrenine; Adrenodis; Adrenohorma; Adrenosan; Adrenutol; Adrin; Adrine; Antiasthmatique; Asthmanefrin; Astmahalin; Astminhal; Balmadren; Bernarenin; Biorenine; Bosmin; Brevirenin; Bronkaid; Chelafrin; Corisol; Drenamist; Dylephrin; Epifrin; Epiglaufrin; Epinefrin; Epinefrina; Epinephran; Epinephrin; Epinephrinum; Epipen; Epirenamine; Epirenan; Epirenin; Epitrate; Eppy; Esphygmogenina; Exadrin; Glaucon; Glaucosan; Glauposine; Glycirenan; Haemostasin; Haemostatin; Hektalin; Hemisine; Hemostasin; Hemostatin; Hypernephrin; Hyporenin; IOP; Intranefrin; Iontocaine; Isoptoepinal; Kidoline; Levoadrenaline; Levoepinephrine; Levorenen; Levorenin; Levorenine; Lyophrin; Metanephrin; Methylaminoethanolcatechol; Methylarterenol; Micronefrin; Micronephrine; Mucidrina; Myosthenine; Mytrate; Nephridine; Nieraline; Paranephrin; Primatene; Racepinephrine; Renagladin; Renaglandin; Renaglandulin; Renaleptine; Renalina; Renoform; Renostypricin; Renostypticin; Renostyptin; Scurenaline; Septocaine; Simplene; Sindrenina; Soladren; Sphygmogenin; Stryptirenal; Styptirenal; Supracapsulin; Supradin; Supranefran; Supranephrane; Supranephrine; Supranol; Suprarenaline; Suprarenin; Suprel; Surenine; Surrenine; Susphrine; Takamina; Takamine; Tokamina; Tonogen; Twinject; Vaponefrin; Vasoconstrictine; Vasoconstrictor; Vasodrine; Vasoton; Vasotonin; ADR ADRENALINE; Adrenalin in Oil; Adrenalina [DCIT]; Asmatane Mist; Asthma meter mist; Asthmahaler Mist; Bronkaid Mist; Bronkaid Suspension Mist; Bupivacaine Hcl and Epinephrine; Citanest Forte; EPI E Z PEN JR; EPIPEN E Z PEN; EPIPEN JR; Epi EZ Pen Jr; Epinefrin [Czech]; Epinephrine hydrochloride; Epipen EZ Pen; Primatene Mist; Racemic Epinephrine; Sympathin I; Adrenalin (TN); Adrenalin-Medihaler; Adrenaline (JP15); Adrenaline/Epinephrine; Ana-Guard; Asthma-nefrin; D-Adrenaline; D-Epifrin; D-Epinephrine; Dyspne-Inhal; Epinefrina [INN-Spanish]; Epinephrine (USP); Epinephrinum [INN-Latin]; Epipen (TN); Epipen Auto-Injector; Epipen Jr.; L-Adrenalin; L-Adrenaline; L-Adrenaline Base; L-Epinehphrine; L-Epinephine; L-Epirenamine; L-Methylaminoethanolcatechol; L-epinephrine; Levo-Methylaminoethanolcatechol; Medihaler-Epi; R-Adrenaline; Sus-Phrine; Twinject 0.15; Twinject 0.3; Twinject 0.30; Epinephrine (USP/INN); Epinephrine [USAN:INN:JAN]; Epipen Jr. Auto-Injector; L-Epinephrine (synthetic); SUS-PHRINE SULFITE-FREE; R-(-)-Epinephrine; L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; (-)-(R)-Epinephrine; (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol; (-)-Adrenalin; (-)-Adrenaline; (-)-R-Epinephrine; (R)-(-)-Adnephrine; (R)-(-)-Adrenaline; (R)-(-)-Epinephrine; (R)-(-)-Epirenamine; (R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (R)-Adrenaline; (R)-Epinephrine; 1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; 1-Adrenalin; 1-Epinephrine; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; 4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
Indication
Disease Entry ICD 11 Status REF
Acute asthma CA23 Approved [1]
Allergy 4A80-4A85 Approved [2]
Anaphylaxis Approved [1]
Bronchiectasis CA24 Approved [1]
Bronchitis CA20 Approved [1]
Periodontitis DA0C Approved [1]
Pulmonary emphysema CA21.Z Approved [1]
Severe asthma CA23 Approved [1]
Asthma CA23 Investigative [1]
Therapeutic Class
Vasoconstrictor Agents
Cross-matching ID
PubChem CID
5816
ChEBI ID
CHEMBL679
CAS Number
CAS 51-43-4
TTD Drug ID
DM3KJBC
VARIDT Drug ID
DR00076
INTEDE Drug ID
DR0590
ACDINA Drug ID
D00234

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [17]
Norepinephrine DMOUC09 Alopecia ED70 Approved [18]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [19]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [19]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [19]
Timolol DM3NXRU High blood pressure BA00 Approved [20]
Isoproterenol DMK7MEY Atrioventricular block Approved [21]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [22]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [23]
Nadolol DMW6GVL Angina pectoris BA40 Approved [24]
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Drug(s) Transported By Organic cation transporter 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [25]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [4]
Metformin DM89QE1 Colorectal carcinoma Approved [26]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [25]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [27]
Norepinephrine DMOUC09 Alopecia ED70 Approved [4]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [28]
Acetylcholine DMDF79Z Cataract 9B10 Approved [29]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [30]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [31]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [5]
Verapamil DMA7PEW Angina pectoris BA40 Approved [36]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [37]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [38]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [39]
Propranolol DM79NTF Angina pectoris BA40 Approved [25]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [40]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [41]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [46]
Metronidazole DMTIVEN Abscess Approved [47]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [48]
Ethanol DMDRQZU Chronic pain MG30 Approved [49]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [51]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [53]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [54]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [55]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [56]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [57]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [58]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [59]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [61]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [62]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [63]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [64]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [65]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [66]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [67]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [68]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [69]
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Drug(s) Metabolized By Catechol O-methyltransferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [70]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [71]
METHYLENEDIOXYMETHAMPHETAMINE DMYVU47 Discovery agent N.A. Investigative [72]
Drug(s) Metabolized By Monoamine oxidase type A (MAO-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [73]
Naratriptan DMO50U2 Headache 8A80-8A84 Approved [74]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [75]
Almotriptan malate DMFG5ST N. A. N. A. Approved [76]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [77]
PHENETHYLAMINE DMX0G4F Discovery agent N.A. Investigative [77]
Benzylamine DMRM6ES N. A. N. A. Investigative [77]
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Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [14]
Norepinephrine DMOUC09 Alopecia ED70 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [79]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [80]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [83]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [84]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [85]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Selenium DM25CGV N. A. N. A. Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [91]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [88]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [95]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [96]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [97]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [98]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [99]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [100]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [101]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [102]
Chlorthalidone DM4DMBT Edema MG29 Approved [103]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [104]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [105]
Bambuterol DMKLSHF Asthma CA23 Approved [106]
Terbutaline DMD4381 Asthma CA23 Approved [107]
Salbutamol DMN9CWF Acute asthma CA23 Approved [108]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [112]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [113]
Propranolol DM79NTF Angina pectoris BA40 Approved [114]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [115]
Gefitinib DM15F0X Colon adenocarcinoma Approved [116]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [118]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [119]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [120]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [119]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [121]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [123]
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Drug(s) Affected By Alpha-1D adrenergic receptor (ADRA1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alfuzosin DMZVMKF Benign prostatic hyperplasia GA90 Approved [124]
Verapamil DMA7PEW Angina pectoris BA40 Approved [125]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [126]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Terbutaline DMD4381 Asthma CA23 Approved [128]
Methoxamine DMF5XQH Hypertension BA00-BA04 Approved [126]
Quinidine DMLPICK N. A. N. A. Approved [125]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [128]
Norepinephrine DMOUC09 Alopecia ED70 Approved [126]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [129]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [130]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [131]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Fructose DM43AN2 Vomiting MD90 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [130]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [136]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [137]
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Drug(s) Affected By Alpha-1A adrenergic receptor (ADRA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamsulosin DM5QF9V Benign prostatic hyperplasia GA90 Approved [138]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [11]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [139]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Quinidine DMLPICK N. A. N. A. Approved [125]
Norepinephrine DMOUC09 Alopecia ED70 Approved [124]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [140]
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Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [141]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [142]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [143]
Terbutaline DMD4381 Asthma CA23 Approved [128]
Quinidine DMLPICK N. A. N. A. Approved [125]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [144]
Arsenic DMTL2Y1 N. A. N. A. Approved [145]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [146]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Gefitinib DM15F0X Colon adenocarcinoma Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Fructose DM43AN2 Vomiting MD90 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [153]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [154]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [155]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [156]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [157]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [158]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [159]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [160]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [161]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [162]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [163]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [164]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [162]
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Drug(s) Affected By Equilibrative nucleoside transporter 4 (SLC29A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [168]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [169]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [170]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [144]
Norepinephrine DMOUC09 Alopecia ED70 Approved [14]
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Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [171]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [12]
Rilmenidine DM13PQW Hypertension BA00-BA04 Approved [172]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [173]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [174]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [127]
Indapamide DMGN1PW Edema MG29 Approved [177]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Agonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [4]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [6]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [7]
Monoamine oxidase type A (MAO-A) DERE4TU AOFA_HUMAN Substrate [8]
Catechol O-methyltransferase (COMT) DEV3T4A COMT_HUMAN Substrate [9]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-1A adrenergic receptor (ADRA1A) OTUIWCL5 ADA1A_HUMAN Gene/Protein Processing [11]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Gene/Protein Processing [11]
Alpha-1D adrenergic receptor (ADRA1D) OTW2CD1O ADA1D_HUMAN Gene/Protein Processing [11]
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Drug Response [12]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Gene/Protein Processing [13]
Equilibrative nucleoside transporter 4 (SLC29A4) OTWTZXMX S29A4_HUMAN Regulation of Drug Effects [14]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Drug Response [12]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [15]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [16]
Solute carrier family 22 member 3 (SLC22A3) OTQYGVXX S22A3_HUMAN Regulation of Drug Effects [14]

References

1 Epinephrine FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 509).
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