Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3WVPJ)

Drug Name
Asacolitin Drug Info
Synonyms
Apriso; Asacol; Asacol HD; 5-Aminosalicylic acid; Benzoic acid, 5-amino-2-hydroxy-; Canasa; Claversal; Fisalamine; Lialda; Lixacol; Mesalamine [USAN]; Mesalazina; Mesalazina [Spanish]; Mesalazine; Mesalazinum; Mesalazinum [Latin]; Mesasal; Pentasa; Rowasa; Salofalk; m-Aminosalicylic acid; mesalamine; p-Aminosalicylsaeure; p-Aminosalicylsaeure [German]; sfRowasa; 2-Hydroxy-5-aminobenzoic acid; 5-ASA; 5-Amino Salicylic Acid; 5-Amino-2-hydroxybenzoic acid; 5-amino-2-hydroxy-benzoic acid; 89-57-6
Cross-matching ID
PubChem CID
4075
ChEBI ID
CHEBI:6775
CAS Number
CAS 89-57-6
TTD Drug ID
DM3WVPJ
INTEDE Drug ID
DR1967

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By N-acetyltransferase 1 (NAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [8]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [9]
Amifampridine DMK08L3 LambertEaton myasthenic syndrome 8C62 Approved [10]
Drug(s) Metabolized By N-acetyltransferase 2 (NAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [11]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [12]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [13]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [9]
Amifampridine DMK08L3 LambertEaton myasthenic syndrome 8C62 Approved [10]
Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [14]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [19]
Folic Acid DMEMBJC Colorectal carcinoma Approved [14]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [20]
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Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [21]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [2]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [22]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Quercetin DM3NC4M Obesity 5B81 Approved [24]
Testosterone DM7HUNW Hot flushes GA30 Approved [17]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Gefitinib DM15F0X Colon adenocarcinoma Approved [29]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [30]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [31]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [30]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [32]
Selenium DM25CGV N. A. N. A. Approved [33]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [34]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [35]
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Drug(s) Affected By Tropomyosin alpha-3 chain (TPM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [38]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [39]
Benzatropine DMF7EXL Parkinsonian disorder Approved [40]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [41]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [41]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [42]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
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Drug(s) Affected By Growth-regulated alpha protein (CXCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [46]
Selenium DM25CGV N. A. N. A. Approved [33]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [51]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [50]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [52]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Gefitinib DM15F0X Colon adenocarcinoma Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [55]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [56]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [57]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [56]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [58]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
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Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [62]
Selenium DM25CGV N. A. N. A. Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [67]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [4]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [4]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [72]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [73]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [4]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [4]
Ethacrynic acid DM60QMR Edema MG29 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [4]
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Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [79]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [18]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [80]
Ethanol DMDRQZU Chronic pain MG30 Approved [81]
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Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Enalapril DMNFUZR Congestive heart failure BD10 Approved [82]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [83]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [84]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [85]
Methotrexate DM2TEOL Anterior urethra cancer Approved [86]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [87]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [88]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [88]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [89]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [90]
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Drug(s) Affected By Solute carrier organic anion transporter family member 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [91]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [92]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [89]
Trospium chloride DM32XZT Discovery agent N.A. Approved [93]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [94]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [76]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [96]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
N-acetyltransferase 1 (NAT1) DE7OAB3 ARY1_HUMAN Substrate [1]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Substrate [1]
Arylamine N-acetyltransferase (NAT) DEG7L5K A0A5E5R1G5_PSEAI Substrate [1]
Arylamine N-acetyltransferase (NAT) DE2S6QE A0A1C3HAL9_SERMA Substrate [1]
Arylamine N-acetyltransferase (NAT) DEF5JD3 A0A1C3Q7F5_KLEPN Substrate [1]
Arylamine N-acetyltransferase (NAT) DEJ01UG NHOA_SALTY Substrate [1]
Arylamine N-acetyltransferase (NAT) DEPI0ME A0A0A2RAD0_MORMO Substrate [1]
Arylamine N-acetyltransferase (NAT) DE5DY7B A0A0D7LKP9_CITFR Substrate [1]
Arylamine N-acetyltransferase (NAT) DE97F4R A0A1C3HAL9_SERMA Substrate [1]
Arylamine N-acetyltransferase (NAT) DE14FI7 A0A0H3HB23_KLEOK Substrate [1]
Arylamine N-acetyltransferase (NAT) DEFHZW7 A0A3P8LE58_TSUPA Substrate [1]
Arylamine N-acetyltransferase (NAT) DEKBP7I A0A5E5R1G5_PSEAI Substrate [1]
Arylamine N-acetyltransferase (NAT) DE6C3R7 A0A223JRX2_9ENTR Substrate [1]
Arylamine N-acetyltransferase (NAT) DE8V274 A0A381G6X4_CITAM Substrate [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Biotransformations [2]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Biotransformations [2]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Protein Interaction/Cellular Processes [3]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Gene/Protein Processing [4]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [5]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Gene/Protein Processing [5]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [6]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Regulation of Drug Effects [7]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Regulation of Drug Effects [7]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Regulation of Drug Effects [7]

References

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30 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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38 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
39 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
40 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
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42 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
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44 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
45 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
46 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
47 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
48 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
49 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
50 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
51 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
52 Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
53 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
54 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
55 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
56 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
57 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
58 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
59 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
60 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
61 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
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